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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Article

Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas

  • Authors:
    • A. G. Kondratov
    • L. A. Stoliar
    • S. M. Kvasha
    • V. V. Gordiyuk
    • Y. M. Zgonnyk
    • A. V. Gerashchenko
    • A. F. Vozianov
    • A. V. Rynditch
    • E. R. Zabarovsky
    • V. I. Kashuba
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine, Institute of Urology, Academy of Medical Sciences, 04053 Kiev, Ukraine, Department of Functional Genomics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine, MTC, Karolinska Institute, Stockholm 17177, Sweden
  • Pages: 509-512
    |
    Published online on: November 16, 2011
       https://doi.org/10.3892/mmr.2011.681
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Abstract

The leucine rich repeat containing 3B (LRRC3B) gene is a putative tumor suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently altered in colon and gastric cancers and also in leukaemias. In this study we investigated the promoter region methylation as a possible mechanism of LRRC3B gene inactivation in clear cell renal cell carcinomas. We found that the LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. However, no correlation between DNA methylation and LRRC3B expression was found.

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Copy and paste a formatted citation
Spandidos Publications style
Kondratov AG, Stoliar LA, Kvasha SM, Gordiyuk VV, Zgonnyk YM, Gerashchenko AV, Vozianov AF, Rynditch AV, Zabarovsky ER, Kashuba VI, Kashuba VI, et al: Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas. Mol Med Rep 5: 509-512, 2012.
APA
Kondratov, A.G., Stoliar, L.A., Kvasha, S.M., Gordiyuk, V.V., Zgonnyk, Y.M., Gerashchenko, A.V. ... Kashuba, V.I. (2012). Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas. Molecular Medicine Reports, 5, 509-512. https://doi.org/10.3892/mmr.2011.681
MLA
Kondratov, A. G., Stoliar, L. A., Kvasha, S. M., Gordiyuk, V. V., Zgonnyk, Y. M., Gerashchenko, A. V., Vozianov, A. F., Rynditch, A. V., Zabarovsky, E. R., Kashuba, V. I."Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas". Molecular Medicine Reports 5.2 (2012): 509-512.
Chicago
Kondratov, A. G., Stoliar, L. A., Kvasha, S. M., Gordiyuk, V. V., Zgonnyk, Y. M., Gerashchenko, A. V., Vozianov, A. F., Rynditch, A. V., Zabarovsky, E. R., Kashuba, V. I."Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas". Molecular Medicine Reports 5, no. 2 (2012): 509-512. https://doi.org/10.3892/mmr.2011.681
Copy and paste a formatted citation
x
Spandidos Publications style
Kondratov AG, Stoliar LA, Kvasha SM, Gordiyuk VV, Zgonnyk YM, Gerashchenko AV, Vozianov AF, Rynditch AV, Zabarovsky ER, Kashuba VI, Kashuba VI, et al: Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas. Mol Med Rep 5: 509-512, 2012.
APA
Kondratov, A.G., Stoliar, L.A., Kvasha, S.M., Gordiyuk, V.V., Zgonnyk, Y.M., Gerashchenko, A.V. ... Kashuba, V.I. (2012). Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas. Molecular Medicine Reports, 5, 509-512. https://doi.org/10.3892/mmr.2011.681
MLA
Kondratov, A. G., Stoliar, L. A., Kvasha, S. M., Gordiyuk, V. V., Zgonnyk, Y. M., Gerashchenko, A. V., Vozianov, A. F., Rynditch, A. V., Zabarovsky, E. R., Kashuba, V. I."Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas". Molecular Medicine Reports 5.2 (2012): 509-512.
Chicago
Kondratov, A. G., Stoliar, L. A., Kvasha, S. M., Gordiyuk, V. V., Zgonnyk, Y. M., Gerashchenko, A. V., Vozianov, A. F., Rynditch, A. V., Zabarovsky, E. R., Kashuba, V. I."Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas". Molecular Medicine Reports 5, no. 2 (2012): 509-512. https://doi.org/10.3892/mmr.2011.681
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