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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March 2012 Volume 5 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain

  • Authors:
    • Yating Chong
    • Tian Wang
    • Wenyan Wang
    • Leiming Zhang
    • Chong Li
    • Pengfei Yu
    • Hongsheng Wang
    • Fenghua Fu

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China
  • Pages: 812-816
    |
    Published online on: November 28, 2011
       https://doi.org/10.3892/mmr.2011.691
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Abstract

P-glycoprotein (P-gp) plays a key role in the distribution and elimination of many clinically important therapeutic substances. P-gp inhibition is capable of increasing the concentration of various drugs in the brain. Danshensu is a main hydrophilic constituent of Salvia miltiorrhiza Bunge which is used traditionally to treat cerebrovascular diseases. In the present study, the effects of cerebral ischemia/reperfusion on the transport of Danshensu in the brain were observed by assaying the concentration at 15, 30 and 60 min after cerebral ischemia/reperfusion in the brain of rats. Furthermore, the expression of P-gp in the brain was also measured. Results showed that Danshensu concentrations in the ischemic hemisphere significantly increased compared to those in the non-ischemic hemisphere and the brain of the sham group. P-gp expression was inhibited by cerebral ischemia/reperfusion to some extent, and down-regulated much more by Danshensu treatment. The findings indicate that the down-regulation of P-gp expression induced by both cerebral ischemia/reperfusion and Danshensu treatment contributes to the increase of Danshensu accumulation in the brain.

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Copy and paste a formatted citation
Spandidos Publications style
Chong Y, Wang T, Wang W, Zhang L, Li C, Yu P, Wang H and Fu F: Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain. Mol Med Rep 5: 812-816, 2012.
APA
Chong, Y., Wang, T., Wang, W., Zhang, L., Li, C., Yu, P. ... Fu, F. (2012). Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain. Molecular Medicine Reports, 5, 812-816. https://doi.org/10.3892/mmr.2011.691
MLA
Chong, Y., Wang, T., Wang, W., Zhang, L., Li, C., Yu, P., Wang, H., Fu, F."Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain". Molecular Medicine Reports 5.3 (2012): 812-816.
Chicago
Chong, Y., Wang, T., Wang, W., Zhang, L., Li, C., Yu, P., Wang, H., Fu, F."Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain". Molecular Medicine Reports 5, no. 3 (2012): 812-816. https://doi.org/10.3892/mmr.2011.691
Copy and paste a formatted citation
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Spandidos Publications style
Chong Y, Wang T, Wang W, Zhang L, Li C, Yu P, Wang H and Fu F: Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain. Mol Med Rep 5: 812-816, 2012.
APA
Chong, Y., Wang, T., Wang, W., Zhang, L., Li, C., Yu, P. ... Fu, F. (2012). Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain. Molecular Medicine Reports, 5, 812-816. https://doi.org/10.3892/mmr.2011.691
MLA
Chong, Y., Wang, T., Wang, W., Zhang, L., Li, C., Yu, P., Wang, H., Fu, F."Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain". Molecular Medicine Reports 5.3 (2012): 812-816.
Chicago
Chong, Y., Wang, T., Wang, W., Zhang, L., Li, C., Yu, P., Wang, H., Fu, F."Down-regulation of P-glycoprotein expression contributes to an increase in Danshensu accumulation in the cerebral ischemia/reperfusion brain". Molecular Medicine Reports 5, no. 3 (2012): 812-816. https://doi.org/10.3892/mmr.2011.691
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