Hypolipidemic effects of kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside in hyperlipidemic rats induced by a high-fat diet

  • Authors:
    • Xue-Zhong Zhao
    • Xu-Wen Li
    • Yong-Ri Jin
    • Xiao-Feng Yu
    • Shao-Chun Qu
    • Da-Yuan Sui
  • View Affiliations

  • Published online on: December 15, 2011     https://doi.org/10.3892/mmr.2011.714
  • Pages: 837-841
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Abstract

Kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside (A-F-B) is a novel flavonoid which is extracted from the leaves of Actinidia kolomikta. The aim of this study was to investigate the hypolipidemic effects of A-F-B in hyperlipidemic rats induced by a high-fat diet. Male Wistar rats were randomly divided into six groups: normal diet group, high-fat diet group, lovastatin (2.5 mg/kg) group and A-F-B (12.5, 25 or 50 mg/kg) groups. To evaluate the lipid-lowering effects of A-F-B, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), atherogenic index (AI) and coronary risk index (CRI) were investigated. The activities of phosphatidate phosphohydrolase (PAP) and hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase in hepatic tissue were evaluated. Treatment with A-F-B to hyperlipidemic rats resulted in a significant decline in TC, TG, LDL-C, AI and CRI, with an increase in HDL-C level. The results also showed that A-F-B significantly decreased the activities of PAP and HMG-CoA reductase in hepatic tissue. These findings suggest that A-F-B improves lipid profiles. The mechanisms of A-F-B were associated with regulating the activities of PAP and HMG-CoA reductase in hepatic tissue.

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March 2012
Volume 5 Issue 3

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Spandidos Publications style
Zhao X, Li X, Jin Y, Yu X, Qu S and Sui D: Hypolipidemic effects of kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside in hyperlipidemic rats induced by a high-fat diet. Mol Med Rep 5: 837-841, 2012.
APA
Zhao, X., Li, X., Jin, Y., Yu, X., Qu, S., & Sui, D. (2012). Hypolipidemic effects of kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside in hyperlipidemic rats induced by a high-fat diet. Molecular Medicine Reports, 5, 837-841. https://doi.org/10.3892/mmr.2011.714
MLA
Zhao, X., Li, X., Jin, Y., Yu, X., Qu, S., Sui, D."Hypolipidemic effects of kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside in hyperlipidemic rats induced by a high-fat diet". Molecular Medicine Reports 5.3 (2012): 837-841.
Chicago
Zhao, X., Li, X., Jin, Y., Yu, X., Qu, S., Sui, D."Hypolipidemic effects of kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside in hyperlipidemic rats induced by a high-fat diet". Molecular Medicine Reports 5, no. 3 (2012): 837-841. https://doi.org/10.3892/mmr.2011.714