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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March 2012 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells

  • Authors:
    • Haitao Zhou
    • Shiyan Chen
    • Wei Wang
    • Zhiqiang Wang
    • Xiuli Wu
    • Zhijian Zhang

  • View Affiliations / Copyright

    Affiliations: Neurology Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China, Fujian Institute of Neurology, Fujian Medical University, Fuzhou, P.R. China
  • Pages: 842-846
    |
    Published online on: December 19, 2011
       https://doi.org/10.3892/mmr.2011.719
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Abstract

Nanog is an essential transcription factor maintaining the self-renewal and pluripotency of embryonic stem cells, which binds to nuclear factor-κB (NF-κB) proteins, inhibits their transcriptional activity and represses their pro-differentiation activity. The persistent and excessive activation of microglial cells, as primary immune cells in the central nervous system is associated with various nerve system diseases, such as neuropathic pain, ischemia, infection, as well as neurodegenerative diseases. However, the effects of Nanog on the activation of microglial cells have yet to be elucidated. In this study, we investigated whether Nanog inhibits the production of pro-inflammatory factors in lipopolysaccharide (LPS)-stimulated microglial cells. Nanog was shown to down-regulate the mRNA and protein levels of IL-1β, TNF-α and IL-6 in LPS-stimulated rat primary microglial cells. Furthermore, we also found that the transcriptional activity of NF-κB was dramatically reduced by Nanog, which was measured using luciferase assay. The results suggest that Nanog reduces the production of pro-inflammatory cytokines and attenuates inflammatory responses in LPS-stimulated microglial cells by blocking the transcriptional activity of NF-κB. Thus, Nanog may be a potentially useful anti-inflammatory therapy for the treatment of various nervous system diseases.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Chen S, Wang W, Wang Z, Wu X and Zhang Z: Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells. Mol Med Rep 5: 842-846, 2012.
APA
Zhou, H., Chen, S., Wang, W., Wang, Z., Wu, X., & Zhang, Z. (2012). Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells. Molecular Medicine Reports, 5, 842-846. https://doi.org/10.3892/mmr.2011.719
MLA
Zhou, H., Chen, S., Wang, W., Wang, Z., Wu, X., Zhang, Z."Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells". Molecular Medicine Reports 5.3 (2012): 842-846.
Chicago
Zhou, H., Chen, S., Wang, W., Wang, Z., Wu, X., Zhang, Z."Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells". Molecular Medicine Reports 5, no. 3 (2012): 842-846. https://doi.org/10.3892/mmr.2011.719
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Chen S, Wang W, Wang Z, Wu X and Zhang Z: Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells. Mol Med Rep 5: 842-846, 2012.
APA
Zhou, H., Chen, S., Wang, W., Wang, Z., Wu, X., & Zhang, Z. (2012). Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells. Molecular Medicine Reports, 5, 842-846. https://doi.org/10.3892/mmr.2011.719
MLA
Zhou, H., Chen, S., Wang, W., Wang, Z., Wu, X., Zhang, Z."Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells". Molecular Medicine Reports 5.3 (2012): 842-846.
Chicago
Zhou, H., Chen, S., Wang, W., Wang, Z., Wu, X., Zhang, Z."Nanog inhibits lipopolysaccharide-induced expression of pro-inflammatory cytokines by blocking NF-κB transcriptional activity in rat primary microglial cells". Molecular Medicine Reports 5, no. 3 (2012): 842-846. https://doi.org/10.3892/mmr.2011.719
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