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Article

Protective effects of glutamine in a rat model of endotoxemia

  • Authors:
    • Ya-Juan Zhao
    • Hong Wang
    • Xin Liu
    • Mei Sun
    • Haginoya Kazuhiro
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Pediatric Neurology Takuto Rehabilitation Center for Children, Sendai 982-0241, Japan
  • Pages: 739-744
    |
    Published online on: July 26, 2012
       https://doi.org/10.3892/mmr.2012.1007
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Abstract

The aim of this study was to characterize the protective effects of glutamine (Gln) on brain cells undergoing experimental endotoxemia induced by lipopolysaccharide (LPS) injection. Young rats were injected with LPS or control, and a subset of LPS-injected rats were pretreated with Gln. Electron microscopy and immunohistochemistry were used to visualize apoptosis and to determine distribution and expression of nuclear factor-κB (NF-κB), heat shock protein 70 (HSP70), platelet-derived growth factor-B (PDGF-B) and PDGF receptor-β (PDGFR-β). The levels of HSP70, PDGF-B and PDGFR-β in the rat brain were comparatively analyzed by western blotting. In a rat brain model of endotoxemia, Gln decreases the magnitude of apoptosis, upregulates the expression of HSP70 and inhibits the translocation of NF-κB from the cytoplasm to the nucleus. Gln upregulates PDGF-B and PDGFR-β expression in early and advanced sepsis. PDGF-B and PDGFR-β upregulation in the cerebral cortex are likely neuroprotective effects of Gln. We found that Gln is capable of regulating the immunological defense of local brain tissue, which provides a theoretical basis for using Gln to prevent and treat encephalopathy.
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1 

Wischmeyer PE, Kahana M, Wolfson R, Ren H, Musch MM and Chang EB: Glutamine induces heat shock protein and protects against endotoxin shock in the rat. J Appl Physiol. 90:2403–2410. 2001.PubMed/NCBI

2 

Opie LH: Reperfusion injury and its pharmacologic modification. Circulation. 80:1049–1062. 1989. View Article : Google Scholar : PubMed/NCBI

3 

Ribeiro SP, Villar J and Slutsky AS: Induction of the stress response to prevent organ injury. New Horiz. 3:301–311. 1995.PubMed/NCBI

4 

De Maio A: Heat shock proteins: facts, thoughts, and dreams. Shock. 11:1–12. 1999.

5 

Chu EK, Ribeiro SP and Slutsky AS: Heat stress increases survival rates in lipopolysaccharide-stimulated rats. Crit Care Med. 25:1727–1732. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Stice JP and Knowlton AA: Estrogen, NFkappaB, and the heat shock response. Mol Med. 14:517–527. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Voegeli TS, Wintink AJ, Chen Y and Currie RW: Heat shock proteins 27 and 70 regulating angiotensin II-induced NF-kappaB: a possible connection to blood pressure control? Appl Physiol Nutr Metab. 33:1042–1049. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Yoo CG, Lee S, Lee CT, Kim YW, Han SK and Shim YS: Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells. J Immunol. 164:5416–5423. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Rogister B, Ben-Hur T and Dubois-Dalcq M: From neural stem cells to myelinating oligodendrocytes. Mol Cell Neurosci. 14:287–300. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Dubois-Dalcq M and Murray K: Why are growth factors important in oligodendrocyte physiology? Pathol Biol (Paris). 48:80–86. 2000.PubMed/NCBI

11 

Morioka I, Tsuneishi S, Takada S and Matsuo M: PDGF-alpha receptor expression following hypoxic-ischemic injury in the neonatal rat brain. Kobe J Med Sci. 50:21–30. 2004.PubMed/NCBI

12 

Liu JC, Wang HT and Wang W: Protective effects of alanyl-glutamine on acute lung injury induced by lipopolysaccharide in rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 33:1095–1100. 2008.PubMed/NCBI

13 

Jacob A, Hensley LK, Safratowich BD, Quigg RJ and Alexander JJ: The role of the complement cascade in endotoxin-induced septic encephalopathy. Lab Invest. 87:1186–1194. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Caruso C, Durand D, Schiöth HB, Rey R, Seilicovich A and Lasaga M: Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes. Endocrinology. 148:4918–4926. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Islam Z, Amuzie CJ, Harkema JR and Pestka JJ: Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure. Toxicol Sci. 98:526–541. 2007. View Article : Google Scholar

16 

Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L and Heneka MT: Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neuroanat. 30:144–157. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Chen G, Shi J, Hu Z and Hang C: Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. Mediators Inflamm. 2008:7164582008. View Article : Google Scholar

18 

Chen NJ, Chio II, Lin WJ, et al: Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci USA. 105:12429–12434. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Wang XM, Liang MF, Yuan Y and Jiang W: The different effects of glutamine on macrophage cytokines release in vivo and in vitro. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 20:456–460. 2008.(In Chinese).

20 

Potula R, Dhillion N, Sui Y, Zien CA, Funa K, Pinson D, Mayo MS, Singh DK, Narayan O and Buch S: Association of platelet-derived growth factor-B chain with simian human immunodeficiency virus encephalitis. Am J Pathol. 165:815–824. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Xiyang YB, Liu S, Liu J, Hao CG, Wang ZJ, NI W, Wang XY and Wang TH: Roles of platelet-derived growth factor-B expression in the ventral horn and motor cortex in the spinal cord-hemisected rhesus monkey. J Neurotrauma. 26:275–287. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Tseng HC and Dichter MA: Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons. Neurobiol Dis. 19:77–83. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Iantomasi T, Favilli F, Catarzi S and Vincenzini MT: GSH role on platelet-derived growth factor receptor tyrosine phosphorylation induced by H2O2. Biochem Biophys Res Commun. 280:1279–1285. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Peng F, Dhillon N, Callen S, Yao H, Bokhari S, Zhu X, Baydoun HH and Buch S: Platelet-derived growth factor protects neurons against gp120-mediated toxicity. J Neurovirol. 14:62–72. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M and Funa K: Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice. Mol Cell Neurosci. 37:507–518. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Beazely MA, Weerapura M and Macdonald JF: Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons. Mol Brain. 1:202008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Wang H, Liu X, Sun M and Kazuhiro H: Protective effects of glutamine in a rat model of endotoxemia. Mol Med Rep 6: 739-744, 2012.
APA
Zhao, Y., Wang, H., Liu, X., Sun, M., & Kazuhiro, H. (2012). Protective effects of glutamine in a rat model of endotoxemia. Molecular Medicine Reports, 6, 739-744. https://doi.org/10.3892/mmr.2012.1007
MLA
Zhao, Y., Wang, H., Liu, X., Sun, M., Kazuhiro, H."Protective effects of glutamine in a rat model of endotoxemia". Molecular Medicine Reports 6.4 (2012): 739-744.
Chicago
Zhao, Y., Wang, H., Liu, X., Sun, M., Kazuhiro, H."Protective effects of glutamine in a rat model of endotoxemia". Molecular Medicine Reports 6, no. 4 (2012): 739-744. https://doi.org/10.3892/mmr.2012.1007
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Wang H, Liu X, Sun M and Kazuhiro H: Protective effects of glutamine in a rat model of endotoxemia. Mol Med Rep 6: 739-744, 2012.
APA
Zhao, Y., Wang, H., Liu, X., Sun, M., & Kazuhiro, H. (2012). Protective effects of glutamine in a rat model of endotoxemia. Molecular Medicine Reports, 6, 739-744. https://doi.org/10.3892/mmr.2012.1007
MLA
Zhao, Y., Wang, H., Liu, X., Sun, M., Kazuhiro, H."Protective effects of glutamine in a rat model of endotoxemia". Molecular Medicine Reports 6.4 (2012): 739-744.
Chicago
Zhao, Y., Wang, H., Liu, X., Sun, M., Kazuhiro, H."Protective effects of glutamine in a rat model of endotoxemia". Molecular Medicine Reports 6, no. 4 (2012): 739-744. https://doi.org/10.3892/mmr.2012.1007
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