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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October 2012 Volume 6 Issue 4

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Article

Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats

  • Authors:
    • Zhao-Hui Zhang
    • Li-Na Wu
    • Jing-Gui Song
    • Wen-Qiang Li
  • View Affiliations / Copyright

    Affiliations: The Second Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Biological Psychiatry, Xinxiang 453002, P.R. China
  • Pages: 889-893
    |
    Published online on: July 26, 2012
       https://doi.org/10.3892/mmr.2012.1009
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Abstract

The aim of this study was to investigate the correlation between brain-derived neurotrophic factor (BDNF) expression and cognitive impairment in post‑stroke depression (PSD) rats and to explore the mechanism(s) involved in the process of cognitive impairment. A rat model of focal cerebral ischemia was established by occluding the middle cerebral artery (MCA). Rats were subjected to isolation-housing combined with chronic unexpected mild stress (CUMS) to establish a PSD rat model. The learning and memory abilities of the PSD rat model were evaluated by passive avoidance tests. Real‑time PCR and immunohistochemical methods were used to detect changes in BDNF mRNA and protein expression in the hippocampus. Passive avoidance defects were revealed in the PSD and depression groups. Passive avoidance defects were more evident in the PSD group compared with the depression group and the difference was statistically significant (P<0.05). BDNF expression in the hippocampus was significantly lower in the PSD and depression groups compared with that in the normal control group (P<0.01). No significant difference in BDNF expression was identified between the normal control and stroke groups (P>0.05) or between the PSD and the depression groups (P>0.05). The decrease in BDNF expression in the hippocampus of PSD rats may aggravate cognitive impairment, however, the degree of cognitive impairment cannot be reflected by the expression levels of BDNF in the hippocampus.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wu L, Song J and Li W: Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. Mol Med Rep 6: 889-893, 2012.
APA
Zhang, Z., Wu, L., Song, J., & Li, W. (2012). Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. Molecular Medicine Reports, 6, 889-893. https://doi.org/10.3892/mmr.2012.1009
MLA
Zhang, Z., Wu, L., Song, J., Li, W."Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats". Molecular Medicine Reports 6.4 (2012): 889-893.
Chicago
Zhang, Z., Wu, L., Song, J., Li, W."Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats". Molecular Medicine Reports 6, no. 4 (2012): 889-893. https://doi.org/10.3892/mmr.2012.1009
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wu L, Song J and Li W: Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. Mol Med Rep 6: 889-893, 2012.
APA
Zhang, Z., Wu, L., Song, J., & Li, W. (2012). Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. Molecular Medicine Reports, 6, 889-893. https://doi.org/10.3892/mmr.2012.1009
MLA
Zhang, Z., Wu, L., Song, J., Li, W."Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats". Molecular Medicine Reports 6.4 (2012): 889-893.
Chicago
Zhang, Z., Wu, L., Song, J., Li, W."Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats". Molecular Medicine Reports 6, no. 4 (2012): 889-893. https://doi.org/10.3892/mmr.2012.1009
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