Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November 2012 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2012 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function

  • Authors:
    • Xiangju Liu
    • Jie Qiu
    • Shaohua Zhao
    • Beian You
    • Xiang Ji
    • Yan Wang
    • Xiaopei Cui
    • Qian Wang
    • Haiqing Gao
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Shandong University Qilu Hospital, Jinan, Shandong 250012, P.R. China, Shandong Provincial Key Laboratory of Cardiovascular Proteomics, Jinan, Shandong 250012, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 949-954
    |
    Published online on: August 8, 2012
       https://doi.org/10.3892/mmr.2012.1026
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recent studies indicate that chronic ouabain treatment leads to hypertension and hypertensive vascular remodeling. Grape seed proanthocyanidin extract (GSPE) has been reported to be effective in treating arteriosclerosis, while little is known about its effect on systolic blood pressure and vascular remodeling. In this study, the effects of GSPE on systolic blood pressure and vascular remodeling were analyzed by treating ouabain-induced hypertensive rats with GSPE (250 mg/kg·d). The expression of nitric oxide (NO) and endothelin-1 (ET-1) in thoracic aorta was examined by ELISA; the mRNA and protein levels of TGF-β1 were detected using real-time PCR and western blotting, respectively. The results showed that the systolic blood pressure was significantly decreased following treatment with GSPE, with blocked vascular remodeling. The ET-1 content was reduced while NO production was increased in the GSPE group, which showed improved vascular endothelial function. Moreover, GSPE also reduced TGF-β1 expression in the thoracic aorta, which is a determinant in vascular remodeling. In conclusion, GSPE antagonized ouabain-induced hypertension and vascular remodeling and is recommended as a potential anti-hypertensive agent for patients with hypertensive vascular diseases.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Rudic RD and Sessa WC: Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. Am J Hum Genet. 64:673–677. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Langille BL and O’Donnell F: Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science. 231:405–407. 1986. View Article : Google Scholar : PubMed/NCBI

3 

Ghosh J, Murphy MO, Turner N, Khwaja N, Halka A, Kielty CM and Walker MG: The role of transforming growth factor beta1 in the vascular system. Cardiovasc Pathol. 14:28–36. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Shao ZH, Becker LB, Vanden Hoek TL, Schumacker PT, Li CQ, Zhao D, Wojcik K, Anderson T, Qin Y, Dey L and Yuan CS: Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes. Pharmacol Res. 47:463–469. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Heimark RL, Twardzik DR and Schwartz SM: Inhibition of endothelial regeneration by type-beta transforming growth factor from platelets. Science. 233:1078–1080. 1986. View Article : Google Scholar : PubMed/NCBI

6 

Li RK, Li G, Mickle DA, Weisel RD, Merante F, Luss H, Rao V, Christakis GT and Williams WG: Overexpression of transforming growth factor-beta1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy. Circulation. 96:874–881. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Huang BS and Leenen FH: Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats. Hypertension. 34:107–112. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Hamlyn JM, Hamilton BP and Manunta P: Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis. J Hypertens. 14:151–167. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Ren YP, Huang RW and Lu ZR: Ouabain at pathological concentrations might induce damage in human vascular endothelial cells. Acta Pharmacol Sin. 27:165–172. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Yamakoshi J, Kataoka S, Koga T and Ariga T: Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 142:139–149. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Duarte J, Pérez-Palencia R, Vargas F, Ocete MA, Pérez-Vizcaino F, Zarzuelo A and Tamargo J: Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol. 133:117–124. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Koprdová R, Cebová M and Kristek F: Long-term effect of losartan administration on blood pressure, heart and structure of coronary artery of young spontaneously hypertensive rats. Physiol Res. 58:327–335. 2009.

13 

Ferrandi M, Manunta P, Ferrari P and Bianchi G: The endogenous ouabain: molecular basis of its role in hypertension and cardiovascular complications. Front Biosci. 10:2472–2477. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Schoner W and Scheiner-Bobis G: Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer. Semin Nephrol. 25:343–351. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Hamlyn JM, Ringel R, Schaeffer J, Levinson PD, Hamilton BP, Kowarski AA and Blaustein MP: A circulating inhibitor of (Na+ + K+)ATPase associated with essential hypertension. Nature. 300:650–652. 1982.

16 

Manunta P, Rogowski AC, Hamilton BP and Hamlyn JM: Ouabain-induced hypertension in the rat: relationships among plasma and tissue ouabain and blood pressure. J Hypertens. 12:549–560. 1994. View Article : Google Scholar : PubMed/NCBI

17 

Xavier FE, Rossoni LV, Alonso MJ, Balfagón G, Vassallo DV and Salaices M: Ouabain-induced hypertension alters the participation of endothelial factors in alpha-adrenergic responses differently in rat resistance and conductance mesenteric arteries. Br J Pharmacol. 143:215–225. 2004. View Article : Google Scholar

18 

Bagchi D, Bagchi M, Stohs S, Ray SD, Sen CK and Preuss HG: Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci. 957:260–270. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Sato M, Maulik G, Ray PS, Bagchi D and Das DK: Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury. J Mol Cell Cardiol. 31:1289–1297. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Sato M, Ray PS, Maulik G, Maulik N, Engelman RM, Bertelli AA, Bertelli A and Das DK: Myocardial protection with red wine extract. J Cardiovasc Pharmacol. 35:263–268. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Facino RM, Carini M, Aldini G, Berti F, Rossoni G, Bombardelli E and Morazzoni P: Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats. Life Sci. 64:627–642. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F and Kappagoda T: Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 58:1743–1746. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Fujita K, Matsumura Y, Kita S, Miyazaki Y, Hisaki K, Takaoka M and Morimoto S: Role of endothelin-1 and the ETA receptor in the maintenance of deoxycorticosterone acetate-salt-induced hypertension. Br J Pharmacol. 114:925–930. 1995. View Article : Google Scholar : PubMed/NCBI

24 

Matsuoka H, Nishida H, Nomura G, Van Vliet BN and Toshima H: Hypertension induced by nitric oxide synthesis inhibition is renal nerve dependent. Hypertension. 23:971–975. 1994. View Article : Google Scholar : PubMed/NCBI

25 

Pollock DM, Polakowski JS, Divish BJ and Opgenorth TJ: Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition. Hypertension. 21:660–666. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Qiu C, Engels K and Baylis C: Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension. Am J Physiol. 266:R1470–1476. 1994.PubMed/NCBI

27 

Bujak M and Frangogiannis NG: The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 74:184–195. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu X, Qiu J, Zhao S, You B, Ji X, Wang Y, Cui X, Wang Q and Gao H: Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function. Mol Med Rep 6: 949-954, 2012.
APA
Liu, X., Qiu, J., Zhao, S., You, B., Ji, X., Wang, Y. ... Gao, H. (2012). Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function. Molecular Medicine Reports, 6, 949-954. https://doi.org/10.3892/mmr.2012.1026
MLA
Liu, X., Qiu, J., Zhao, S., You, B., Ji, X., Wang, Y., Cui, X., Wang, Q., Gao, H."Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function". Molecular Medicine Reports 6.5 (2012): 949-954.
Chicago
Liu, X., Qiu, J., Zhao, S., You, B., Ji, X., Wang, Y., Cui, X., Wang, Q., Gao, H."Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function". Molecular Medicine Reports 6, no. 5 (2012): 949-954. https://doi.org/10.3892/mmr.2012.1026
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Qiu J, Zhao S, You B, Ji X, Wang Y, Cui X, Wang Q and Gao H: Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function. Mol Med Rep 6: 949-954, 2012.
APA
Liu, X., Qiu, J., Zhao, S., You, B., Ji, X., Wang, Y. ... Gao, H. (2012). Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function. Molecular Medicine Reports, 6, 949-954. https://doi.org/10.3892/mmr.2012.1026
MLA
Liu, X., Qiu, J., Zhao, S., You, B., Ji, X., Wang, Y., Cui, X., Wang, Q., Gao, H."Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function". Molecular Medicine Reports 6.5 (2012): 949-954.
Chicago
Liu, X., Qiu, J., Zhao, S., You, B., Ji, X., Wang, Y., Cui, X., Wang, Q., Gao, H."Grape seed proanthocyanidin extract alleviates ouabain-induced vascular remodeling through regulation of endothelial function". Molecular Medicine Reports 6, no. 5 (2012): 949-954. https://doi.org/10.3892/mmr.2012.1026
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team