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Article

Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis

  • Authors:
    • Bo Di
    • Xinyuan Li
    • Liqun Song
    • Qianghu Wang
    • Suyan Liu
  • View Affiliations / Copyright

    Affiliations: The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150080, P.R. China, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150080, P.R. China, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150080, P.R. China, Department of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150080, P.R. China
  • Pages: 1171-1177
    |
    Published online on: August 10, 2012
       https://doi.org/10.3892/mmr.2012.1032
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Abstract

Previous studies have shown that insertion/deletion polymorphisms in the angiotensin-converting enzyme (ACE) gene and the endothelial nitric oxide synthase (eNOS) gene are associated with Henoch-Schönlein purpura nephritis (HSPN). However, further studies are required to prove the relationship between HSPN and ACE and eNOS single nucleotide polymorphisms (SNPs). We studied six ACE SNPs and two eNOS SNPs by genotyping HSPN patients. Statistical analyses indicate that four ACE SNPs and two eNOS SNPs are associated with HSPN susceptibility. A cumulative effect analysis suggested that an increased number of unfavourable genotypes may lead to an increased risk of HSPN. By comparing alleles, genotypes and haplotypes that are associated with lupus nephritis (LN) and HSPN, we found genetic heterogeneity between HSPN and LN.
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Copy and paste a formatted citation
Spandidos Publications style
Di B, Li X, Song L, Wang Q and Liu S: Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis. Mol Med Rep 6: 1171-1177, 2012.
APA
Di, B., Li, X., Song, L., Wang, Q., & Liu, S. (2012). Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis. Molecular Medicine Reports, 6, 1171-1177. https://doi.org/10.3892/mmr.2012.1032
MLA
Di, B., Li, X., Song, L., Wang, Q., Liu, S."Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis". Molecular Medicine Reports 6.5 (2012): 1171-1177.
Chicago
Di, B., Li, X., Song, L., Wang, Q., Liu, S."Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis". Molecular Medicine Reports 6, no. 5 (2012): 1171-1177. https://doi.org/10.3892/mmr.2012.1032
Copy and paste a formatted citation
x
Spandidos Publications style
Di B, Li X, Song L, Wang Q and Liu S: Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis. Mol Med Rep 6: 1171-1177, 2012.
APA
Di, B., Li, X., Song, L., Wang, Q., & Liu, S. (2012). Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis. Molecular Medicine Reports, 6, 1171-1177. https://doi.org/10.3892/mmr.2012.1032
MLA
Di, B., Li, X., Song, L., Wang, Q., Liu, S."Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis". Molecular Medicine Reports 6.5 (2012): 1171-1177.
Chicago
Di, B., Li, X., Song, L., Wang, Q., Liu, S."Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis". Molecular Medicine Reports 6, no. 5 (2012): 1171-1177. https://doi.org/10.3892/mmr.2012.1032
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