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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November 2012 Volume 6 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Drug screening study using glioma stem-like cells

  • Authors:
    • Xing Feng
    • Qin Zhou
    • Chong Liu
    • Mei-Ling Tao
  • View Affiliations / Copyright

    Affiliations: College of Medicine, Hunan Normal University, Changsha, Hunan 410006, P.R. China
  • Pages: 1117-1120
    |
    Published online on: August 20, 2012
       https://doi.org/10.3892/mmr.2012.1040
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Abstract

Glioma is one of the most common malignant tumors affecting the central nervous system. We screened active drugs from 12 classes to provide experimental data for the study of human glioma. Serum-free suspension clone formation was used to induce the formation of glioma stem‑like cells (GSLCs) from U251 cells. We screened active drugs from 12 classes and observed their effects on the number of tumor balls. The results revealed that serum‑free suspension clone formation successfully induced the formation of GSLCs. Six active drugs [curcumin, chrysin, apigenin, luteolin, casticin and 8-bromo-7-methoxychrysin (BrMChR)] were identified by MTT assay. The drugs that affected the number of tumor balls were curcumin, luteolin, casticin and BrMChR (all P<0.05). The GSLCs were obtained by serum‑free clone suspension formation and exhibited the features of cancer stem cells.
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Copy and paste a formatted citation
Spandidos Publications style
Feng X, Zhou Q, Liu C and Tao M: Drug screening study using glioma stem-like cells. Mol Med Rep 6: 1117-1120, 2012.
APA
Feng, X., Zhou, Q., Liu, C., & Tao, M. (2012). Drug screening study using glioma stem-like cells. Molecular Medicine Reports, 6, 1117-1120. https://doi.org/10.3892/mmr.2012.1040
MLA
Feng, X., Zhou, Q., Liu, C., Tao, M."Drug screening study using glioma stem-like cells". Molecular Medicine Reports 6.5 (2012): 1117-1120.
Chicago
Feng, X., Zhou, Q., Liu, C., Tao, M."Drug screening study using glioma stem-like cells". Molecular Medicine Reports 6, no. 5 (2012): 1117-1120. https://doi.org/10.3892/mmr.2012.1040
Copy and paste a formatted citation
x
Spandidos Publications style
Feng X, Zhou Q, Liu C and Tao M: Drug screening study using glioma stem-like cells. Mol Med Rep 6: 1117-1120, 2012.
APA
Feng, X., Zhou, Q., Liu, C., & Tao, M. (2012). Drug screening study using glioma stem-like cells. Molecular Medicine Reports, 6, 1117-1120. https://doi.org/10.3892/mmr.2012.1040
MLA
Feng, X., Zhou, Q., Liu, C., Tao, M."Drug screening study using glioma stem-like cells". Molecular Medicine Reports 6.5 (2012): 1117-1120.
Chicago
Feng, X., Zhou, Q., Liu, C., Tao, M."Drug screening study using glioma stem-like cells". Molecular Medicine Reports 6, no. 5 (2012): 1117-1120. https://doi.org/10.3892/mmr.2012.1040
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