Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November 2012 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2012 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Adrenomedullin is involved in the progression of colonic adenocarcinoma

  • Authors:
    • Jee-Youn Kim
    • Won-Do Park
    • Sun Lee
    • Jae-Hoon Park
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea
  • Pages: 1030-1034
    |
    Published online on: August 24, 2012
       https://doi.org/10.3892/mmr.2012.1045
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates in a wide range of physiological and pathological processes, including vasorelaxation, angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor cells against apoptotic cell death via the upregulation of Bcl-2 or the activation of the phosphatidylinositol 3-kinase/Akt pathway. Several studies have also provided evidence that ADM is involved in tumor initiation and progression. However, this has not been shown in gastrointestinal tumors. To investigate the role of ADM in gastrointestinal tumor progression, we determined the expression levels of ADM in 72 cases of stomach cancer and 84 cases of colon cancer and determined whether there was an association between the ADM expression levels and pathological parameters or clinical survival rates. We found that the expression levels of ADM were significantly higher in colon cancers than in matching normal mucosal tissues. In addition, the expression levels of ADM in colon cancers were correlated with cancer stage and clinical survival rate. However, we did not find any significant correlations between ADM expression levels and clinical or pathological parameters in stomach cancers. Taken together, our data strongly suggest that ADM is involved in the progression of colon cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H and Eto T: Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun. 192:553–560. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Eipper BA, Stoffers DA and Mains RE: The biosynthesis of neuropeptides: peptide α-amidation (Review). Annu Rev Neurosci. 15:57–85. 1992.

3 

Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K and Sakata T: The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. FEBS Lett. 448:111–114. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Hinson JP, Kapas S and Smith DM: Adrenomedullin, a multifunctional regulatory peptide (Review). Endocr Rev. 21:138–167. 2000.PubMed/NCBI

5 

Li Z, Takeuchi S, Otani T and Maruo T: Implications of adrenomedullin expression in the invasion of squamous cell carcinoma of the uterine cervix. Int J Clin Oncol. 6:263–270. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Martínez A, Vos M, Guédez L, Kaur G, Chen Z, Garayoa M, Pío R, Moody T, Stetler-Stevenson WG, Kleinman HK and Cuttitta F: The effects of adrenomedullin overexpression in breast tumor cells. J Natl Cancer Inst. 94:1226–1237. 2002.PubMed/NCBI

7 

Zudaire E, Martínez A and Cuttitta F: Adrenomedullin and cancer (Review). Regul Pept. 112:175–183. 2003. View Article : Google Scholar

8 

Hanahan D and Weinberg RA: The hallmarks of cancer (Review). Cell. 100:57–70. 2000. View Article : Google Scholar

9 

Möller P, Koretz K, Leithäuser F, Brüderlein S, Henne C, Quentmeier A and Krammer PH: Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int J Cancer. 57:371–377. 1994.PubMed/NCBI

10 

Rich JN, Borton AJ and Wang X: Transforming growth factor-b signaling in cancer (Review). Microsc Res Tech. 52:363–373. 2001. View Article : Google Scholar

11 

Oehler MK, Norbury C, Hague S, Rees MC and Bicknell R: Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. Oncogene. 20:2937–2945. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Ryu BK, Lee MG, Chi SG, Kim YW and Park JH: Increased expression of cFLIP(L) in colonic adenocarcinoma. J Pathol. 194:15–19. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Hinson JP, Thomson LM and Kapas S: Adrenomedullin and CGRP receptors mediate different effects in the rat adrenal cortex. Endocr Res. 24:725–728. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Satoh F, Takahashi K, Murakami O, Totsune K, Sone M, Ohneda M, Abe K, Miura Y, Hayashi Y and Sasano H: Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. J Clin Endocrinol Metab. 80:1750–1752. 1995.

15 

Martinez A, Miller MJ, Unsworth EJ, Siegfried JM and Cuttitta F: Expression of adrenomedullin in normal human lung and in pulmonary tumors. Endocrinology. 136:4099–4105. 1995.PubMed/NCBI

16 

Ouafik L, Sauze S, Boudouresque F, Chinot O, Delfino C, Fina F, Vuaroqueaux V, Dussert C, Palmari J, Dufour H, et al: Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo. Am J Pathol. 160:1279–1292. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Miller MJ, Martínez A, Unsworth EJ, Thiele CJ, Moody TW, Elsasser T and Cuttitta F: Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor. J Biol Chem. 271:23345–23351. 1996. View Article : Google Scholar : PubMed/NCBI

18 

Nakayama M, Takahashi K, Murakami O, Shirato K and Shibahara S: Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells. Biochem Biophys Res Commun. 243:514–517. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Kitani M, Sakata J, Asada Y, Kitamura K and Eto T: Distribution and expression of adrenomedullin in human gastrointestinal tissue. Ann Clin Biochem. 35:643–648. 1998. View Article : Google Scholar

20 

Marutsuka K, Nawa Y, Asada Y, Hara S, Kitamura K, Eto T and Sumiyoshi A: Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect. Exp Physiol. 86:543–545. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Garayoa M, Martínez A, Lee S, Pio R, An WG, Neckers L, Trepel J, Montuenga LM, Ryan H, Johnson R, et al: Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol. 14:848–862. 2000. View Article : Google Scholar

22 

Zhao Y, Hague S, Manek S, Zhang L, Bicknell R and Rees MC: PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by an non estrogenic mechanism in the human endometrium. Oncogene. 16:409–415. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Kim W, Moon SO, Sung MJ, Kim SH, Lee S, Kim HJ, Koh GY and Park SK: Protective effect of adrenomedullin in mannitol-induced apoptosis. Apoptosis. 7:527–536. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Kamoi H, Kanazawa H, Hirata K, Kurihara N, Yano Y and Otani S: Adrenomedullin inhibits the secretion of cytokine-induced neurtophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages. Biochem Biophys Res Commun. 211:1031–1035. 1995. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim J, Park W, Lee S and Park J: Adrenomedullin is involved in the progression of colonic adenocarcinoma. Mol Med Rep 6: 1030-1034, 2012.
APA
Kim, J., Park, W., Lee, S., & Park, J. (2012). Adrenomedullin is involved in the progression of colonic adenocarcinoma. Molecular Medicine Reports, 6, 1030-1034. https://doi.org/10.3892/mmr.2012.1045
MLA
Kim, J., Park, W., Lee, S., Park, J."Adrenomedullin is involved in the progression of colonic adenocarcinoma". Molecular Medicine Reports 6.5 (2012): 1030-1034.
Chicago
Kim, J., Park, W., Lee, S., Park, J."Adrenomedullin is involved in the progression of colonic adenocarcinoma". Molecular Medicine Reports 6, no. 5 (2012): 1030-1034. https://doi.org/10.3892/mmr.2012.1045
Copy and paste a formatted citation
x
Spandidos Publications style
Kim J, Park W, Lee S and Park J: Adrenomedullin is involved in the progression of colonic adenocarcinoma. Mol Med Rep 6: 1030-1034, 2012.
APA
Kim, J., Park, W., Lee, S., & Park, J. (2012). Adrenomedullin is involved in the progression of colonic adenocarcinoma. Molecular Medicine Reports, 6, 1030-1034. https://doi.org/10.3892/mmr.2012.1045
MLA
Kim, J., Park, W., Lee, S., Park, J."Adrenomedullin is involved in the progression of colonic adenocarcinoma". Molecular Medicine Reports 6.5 (2012): 1030-1034.
Chicago
Kim, J., Park, W., Lee, S., Park, J."Adrenomedullin is involved in the progression of colonic adenocarcinoma". Molecular Medicine Reports 6, no. 5 (2012): 1030-1034. https://doi.org/10.3892/mmr.2012.1045
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team