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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November 2012 Volume 6 Issue 5

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Article

Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases

  • Authors:
    • Huanrong Lan
    • Ketao Jin
    • Bojian Xie
    • Na Han
    • Binbin Cui
    • Feilin Cao
    • Lisong Teng
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Taizhou Hospital, Wenzhou Medical College, Linhai 317000, Zhejiang, P.R. China, Department of Surgical Oncology, Taizhou Hospital, Wenzhou Medical College, Linhai 317000, Zhejiang, P.R. China, Cancer Chemotherapy Center, Zhejiang Cancer Hospital, Zhejiang University of Chinese Medicine, Hangzhou 310022, Zhejiang, P.R. China, Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, P.R. China
  • Pages: 1057-1068
    |
    Published online on: August 28, 2012
       https://doi.org/10.3892/mmr.2012.1051
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Abstract

Heterogeneity is one of the recognized characteristics of human tumors, and occurs on multiple levels in a wide range of tumors. A number of studies have focused on the heterogeneity found in primary tumors and related metastases with the consideration that the evaluation of metastatic rather than primary sites could be of clinical relevance. Numerous studies have demonstrated particularly high rates of heterogeneity between primary colorectal tumors and their paired lymphatic and hepatic metastases. It has also been proposed that the heterogeneity between primary colon carcinomas and their paired lymphatic and hepatic metastases may result in different responses to anticancer therapies. The heterogeneity in primary colon carcinoma and corresponding metastases by genome‑wide gene expression analysis has not been extensively studied. In the present study, we investigated the differentially expressed genes between a primary colon carcinoma specimen (obtained from a 40-year-old female colon carcinoma patient with lymphatic and hepatic metastases) and its paired lymphatic and hepatic metastases by genome-wide gene expression analysis using GeneChip HGU133Plus2.0 expression arrays. Our results demonstrate that genome-wide gene expression varies between primary colon carcinoma and its paired lymphatic and hepatic metastases.
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1 

Jin KT, He KF, Teng F, Han N, Li GL, Xu ZZ and Teng LS: Heterogeneity in primary tumors and corresponding metastases: could it provide us with any hints to personalize cancer therapy? Pers Med. 8:175–182. 2011. View Article : Google Scholar

2 

Gong Y, Booser DJ and Sneige N: Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinoma. Cancer. 103:1763–1769. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Gancberg D, Di Leo A, Cardoso F, Rouas G, Pedrocchi M, Paesmans M, Verhest A, Bernard-Marty C, Piccart MJ and Larsimont D: Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites. Ann Oncol. 13:1036–1043. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Regitnig P, Schippinger W, Lindbauer M, Samonigg H and Lax SF: Change of HER-2/neu status in a subset of distant metastases from breast carcinomas. J Pathol. 203:918–926. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Bozzetti C, Personeni N, Nizzoli R, Guazzi A, Flora M, Bassano C, Negri F, Martella E, Naldi N, Franciosi V and Cascinu S: HER-2/neu amplification by fluorescence in situ hybridization in cytologic samples from distant metastatic sites of breast carcinoma. Cancer. 99:310–315. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Tanner M, Järvinen P and Isola J: Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer. Cancer Res. 61:5345–5348. 2001.PubMed/NCBI

7 

Tapia C, Savic S, Wagner U, Schönegg R, Novotny H, Grilli B, Herzog M, Barascud AD, Zlobec I, Cathomas G, Terracciano L, Feichter G and Bubendorf L: HER2 gene status in primary breast cancers and matched distant metastases. Breast Cancer Res. 9:R312007. View Article : Google Scholar : PubMed/NCBI

8 

Akcakanat A, Sahin A, Shaye AN, Velasco MA and Meric-Bernstam F: Comparison of Akt/mTOR signaling in primary breast tumors and matched distant metastases. Cancer. 112:2352–2358. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Wu JM, Fackler MJ, Halushka MK, Molavi DW, Taylor ME, Teo WW, Griffin C, Fetting J, Davidson NE, De Marzo AM, Hicks JL, Chitale D, Ladanyi M, Sukumar S and Argani P: Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res. 14:1938–1946. 2008. View Article : Google Scholar

10 

Baldus SE, Schaefer KL, Engers R, Hartleb D, Stoecklein NH and Gabbert HE: Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res. 16:790–799. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Molinari F, Martin V, Saletti P, De Dosso S, Spitale A, Camponovo A, Bordoni A, Crippa S, Mazzucchelli L and Frattini M: Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. Br J Cancer. 100:1087–1094. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Scartozzi M, Bearzi I, Berardi R, Mandolesi A, Fabris G and Cascinu S: Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies. J Clin Oncol. 22:4772–4778. 2004. View Article : Google Scholar

13 

Scartozzi M, Bearzi I, Berardi R, Mandolesi A, Pierantoni C and Cascinu S: Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options. Br J Cancer. 97:92–97. 2007. View Article : Google Scholar

14 

Sasatomi E, Finkelstein SD, Woods JD, Bakker A, Swalsky PA, Luketich JD, Fernando HC and Yousem SA: Comparison of accumulated allele loss between primary tumor and lymph node metastasis in stage II non-small cell lung carcinoma: implications for the timing of lymph node metastasis and prognostic value. Cancer Res. 62:2681–2689. 2002.PubMed/NCBI

15 

Park S, Holmes-Tisch AJ, Cho EY, Shim YM, Kim J, Kim HS, Lee J, Park YH, Ahn JS, Park K, Jänne PA and Ahn MJ: Discordance of molecular biomarkers associated with epidermal growth factor receptor pathway between primary tumors and lymph node metastasis in non-small cell lung cancer. J Thorac Oncol. 4:809–815. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Jin K, Li G, Cui B, Zhang J, Lan H, Han N, Xie B, Cao F, He K, Wang H, Xu Z, Teng L and Zhu T: Assessment of a novel VEGF targeted agent using patient-derived tumor tissue xenograft models of colon carcinoma with lymphatic and hepatic metastases. PLoS One. 6:e283842011. View Article : Google Scholar : PubMed/NCBI

17 

Fichtner I, Rolff J, Soong R, Hoffmann J, Hammer S, Sommer A, Becker M and Merk J: Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers. Clin Cancer Res. 14:6456–6468. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Jin KT, He KF, Li GL and Teng LS: Personalized cancer therapy using a patient-derived tumor tissue xenograft model: a translational field worthy of exploring further? Pers Med. 7:597–606. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lan H, Jin K, Xie B, Han N, Cui B, Cao F and Teng L: Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases. Mol Med Rep 6: 1057-1068, 2012.
APA
Lan, H., Jin, K., Xie, B., Han, N., Cui, B., Cao, F., & Teng, L. (2012). Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases. Molecular Medicine Reports, 6, 1057-1068. https://doi.org/10.3892/mmr.2012.1051
MLA
Lan, H., Jin, K., Xie, B., Han, N., Cui, B., Cao, F., Teng, L."Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases". Molecular Medicine Reports 6.5 (2012): 1057-1068.
Chicago
Lan, H., Jin, K., Xie, B., Han, N., Cui, B., Cao, F., Teng, L."Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases". Molecular Medicine Reports 6, no. 5 (2012): 1057-1068. https://doi.org/10.3892/mmr.2012.1051
Copy and paste a formatted citation
x
Spandidos Publications style
Lan H, Jin K, Xie B, Han N, Cui B, Cao F and Teng L: Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases. Mol Med Rep 6: 1057-1068, 2012.
APA
Lan, H., Jin, K., Xie, B., Han, N., Cui, B., Cao, F., & Teng, L. (2012). Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases. Molecular Medicine Reports, 6, 1057-1068. https://doi.org/10.3892/mmr.2012.1051
MLA
Lan, H., Jin, K., Xie, B., Han, N., Cui, B., Cao, F., Teng, L."Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases". Molecular Medicine Reports 6.5 (2012): 1057-1068.
Chicago
Lan, H., Jin, K., Xie, B., Han, N., Cui, B., Cao, F., Teng, L."Heterogeneity between primary colon carcinoma and paired lymphatic and hepatic metastases". Molecular Medicine Reports 6, no. 5 (2012): 1057-1068. https://doi.org/10.3892/mmr.2012.1051
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