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Article

Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats

  • Authors:
    • Jiansheng Xu
    • Ying Li
  • View Affiliations / Copyright

    Affiliations: Department of Physical Education, Tianjin University, Tianjin 300072, P.R. China, Department of Physical Education, Tianjin Agricultural University, Tianjin 300084, P.R. China
  • Pages: 1195-1198
    |
    Published online on: September 3, 2012
       https://doi.org/10.3892/mmr.2012.1060
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Abstract

Intense exercise increases oxygen consumption and may produce an imbalance between reactive oxygen species (ROS) and antioxidants, inducing oxidative stress as a result of increased ROS production. Exogenous antioxidants may prevent oxidative damages since they are able to detoxify certain peroxides by scavenging the ROS produced during exercise. The aim of this study was to evaluate the effects of salidroside on exhaustive exercise-induced oxidative stress in rats. A total of 40 animals were randomly divided into four groups of ten rats each: control (C), low-dose salidroside‑treated (LT), middle-dose salidroside-treated (MT) and high-dose salidroside-treated (HT) groups. The rats in the treated groups received salidroside (25, 50 and 100 mg/kg, respectively) intragastrically (ig) and the rats in the control group received drinking water ig for 4 weeks. After 4 weeks, the rats performed an exhaustive swimming exercise and exhaustive swimming times were recorded. The malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glycogen levels in the liver tissues of the rats were measured. The data revealed that salidroside was able to elevate the exercise tolerance and increase the liver glycogen levels of the rats following exhaustive exercise. Salidroside was also able to reduce MDA levels and enhance the activities of antioxidant enzymes (CAT, SOD and GSH-Px) in the liver tissues of the rats. The results from this study indicate that salidroside is effective in the prevention of oxidative stress following exhaustive exercise.
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Copy and paste a formatted citation
Spandidos Publications style
Xu J and Li Y: Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats. Mol Med Rep 6: 1195-1198, 2012.
APA
Xu, J., & Li, Y. (2012). Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats. Molecular Medicine Reports, 6, 1195-1198. https://doi.org/10.3892/mmr.2012.1060
MLA
Xu, J., Li, Y."Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats". Molecular Medicine Reports 6.5 (2012): 1195-1198.
Chicago
Xu, J., Li, Y."Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats". Molecular Medicine Reports 6, no. 5 (2012): 1195-1198. https://doi.org/10.3892/mmr.2012.1060
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J and Li Y: Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats. Mol Med Rep 6: 1195-1198, 2012.
APA
Xu, J., & Li, Y. (2012). Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats. Molecular Medicine Reports, 6, 1195-1198. https://doi.org/10.3892/mmr.2012.1060
MLA
Xu, J., Li, Y."Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats". Molecular Medicine Reports 6.5 (2012): 1195-1198.
Chicago
Xu, J., Li, Y."Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats". Molecular Medicine Reports 6, no. 5 (2012): 1195-1198. https://doi.org/10.3892/mmr.2012.1060
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