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Article

Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression

  • Authors:
    • Min Zheng
    • Ruifu Chen
    • Hongyuan Zhong
    • Qiuyan Lin
    • Xiaoqin Wang
    • Zhiwei Zhao
    • Linna Xie
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, P.R. China, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, P.R. China, Department of Bioengineering, Fujian Vocational College of Bioengineering, Fuzhou 350007, P.R. China
  • Pages: 1367-1370
    |
    Published online on: September 12, 2012
       https://doi.org/10.3892/mmr.2012.1077
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Abstract

Resveratrol is a natural compound present in red grapes and red wine, and is often consumed in the human diet. The chemopreventive and chemotherapeutic potential of resveratrol in hepatocellular carcinoma (HCC), one of the most common types of liver cancer, has received much attention in recent years. However, the side-effects of resveratrol stimulation are of concern due to the high doses administered to humans. This study investigated the effects of resveratrol on the mRNA expression of pten and bcl-xl in HepG2 cells using semi‑quantitative and quantitative PCR. This study demonstrated that 200 µmol/l resveratrol stimulation for 12 h resulted in the inhibition of HepG2 proliferation, reduced pten and increased bcl-xl mRNA expression. The data suggest that (a) the anticancer mechanism of resveratrol does not involve the induction of pten and inhibition of bcl-xl expression and (b) resveratrol induces a cellular self-protection response, which underlies the cellular chemoresistance against resveratrol in HepG2 cells.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng M, Chen R, Zhong H, Lin Q, Wang X, Zhao Z and Xie L: Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression. Mol Med Rep 6: 1367-1370, 2012.
APA
Zheng, M., Chen, R., Zhong, H., Lin, Q., Wang, X., Zhao, Z., & Xie, L. (2012). Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression. Molecular Medicine Reports, 6, 1367-1370. https://doi.org/10.3892/mmr.2012.1077
MLA
Zheng, M., Chen, R., Zhong, H., Lin, Q., Wang, X., Zhao, Z., Xie, L."Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression". Molecular Medicine Reports 6.6 (2012): 1367-1370.
Chicago
Zheng, M., Chen, R., Zhong, H., Lin, Q., Wang, X., Zhao, Z., Xie, L."Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression". Molecular Medicine Reports 6, no. 6 (2012): 1367-1370. https://doi.org/10.3892/mmr.2012.1077
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng M, Chen R, Zhong H, Lin Q, Wang X, Zhao Z and Xie L: Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression. Mol Med Rep 6: 1367-1370, 2012.
APA
Zheng, M., Chen, R., Zhong, H., Lin, Q., Wang, X., Zhao, Z., & Xie, L. (2012). Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression. Molecular Medicine Reports, 6, 1367-1370. https://doi.org/10.3892/mmr.2012.1077
MLA
Zheng, M., Chen, R., Zhong, H., Lin, Q., Wang, X., Zhao, Z., Xie, L."Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression". Molecular Medicine Reports 6.6 (2012): 1367-1370.
Chicago
Zheng, M., Chen, R., Zhong, H., Lin, Q., Wang, X., Zhao, Z., Xie, L."Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression". Molecular Medicine Reports 6, no. 6 (2012): 1367-1370. https://doi.org/10.3892/mmr.2012.1077
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