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Article

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

  • Authors:
    • So-Jung Kim
    • Hyeong-Jin Kim
    • Hye-Ri Kim
    • Seung-Ho Lee
    • Sung-Dae Cho
    • Chang-Sun Choi
    • Jeong-Seok Nam
    • Ji-Youn Jung
  • View Affiliations / Copyright

    Affiliations: Department of Companion and Laboratory Animal Science, Kongju National University, Yesan 340-702, Republic of Korea, Department of Oral Pathology, School of Dentistry, Chonbuk National University, Jeonju 561-756, Republic of Korea, Department of Food and Nutrition, College of Human Ecology, Chung-Ang University, Ansung 456-756, Republic of Korea, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Inchon 406-840, Republic of Korea
  • Pages: 1443-1449
    |
    Published online on: September 17, 2012
       https://doi.org/10.3892/mmr.2012.1085
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Abstract

The purpose of this study was to determine the effects of baicalein and wogonin, which are compounds derived from the Chinese herb Scutellaria baicalensis, in suppressing the viability of HT-29 human colon cancer cells. Following treatment with baicalein or wogonin, several apoptotic events were observed, including DNA fragmentation, chromatin condensation and increased cell cycle arrest in the G1 phase. Baicalein and wogonin decreased Bcl-2 expression, whereas the expression of Bax was increased in a dose-dependent manner compared with the control. Furthermore, the induction of apoptosis was accompanied by an inactivation of phosphatidylinositol 3-kinase (PI3K)/Akt in a dose-dependent manner. The administration of baicalein to mice resulted in the inhibition of the growth of HT-29 xenografts without any toxicity following 5 weeks of treatment. The results indicated that baicalein induced apoptosis via Akt activation in a p53-dependent manner in the HT-29 colon cancer cells and that it may serve as a chemopreventive or therapeutic agent for HT-29 colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kim S, Kim H, Kim H, Lee S, Cho S, Choi C, Nam J and Jung J: Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Mol Med Rep 6: 1443-1449, 2012.
APA
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C. ... Jung, J. (2012). Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Molecular Medicine Reports, 6, 1443-1449. https://doi.org/10.3892/mmr.2012.1085
MLA
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C., Nam, J., Jung, J."Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells". Molecular Medicine Reports 6.6 (2012): 1443-1449.
Chicago
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C., Nam, J., Jung, J."Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells". Molecular Medicine Reports 6, no. 6 (2012): 1443-1449. https://doi.org/10.3892/mmr.2012.1085
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Kim H, Kim H, Lee S, Cho S, Choi C, Nam J and Jung J: Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Mol Med Rep 6: 1443-1449, 2012.
APA
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C. ... Jung, J. (2012). Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Molecular Medicine Reports, 6, 1443-1449. https://doi.org/10.3892/mmr.2012.1085
MLA
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C., Nam, J., Jung, J."Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells". Molecular Medicine Reports 6.6 (2012): 1443-1449.
Chicago
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C., Nam, J., Jung, J."Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells". Molecular Medicine Reports 6, no. 6 (2012): 1443-1449. https://doi.org/10.3892/mmr.2012.1085
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