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Article

Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway

  • Authors:
    • Kun Lv
    • Yingying Zhang
    • Mengying Zhang
    • Min Zhong
    • Qifeng Suo
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Wannan Medical College, Wuhu 241001, P.R. China, Laboratory Medicine of Yijishan Hospital, Wannan Medical College, Wuhu 241001, P.R. China
  • Pages: 205-210
    |
    Published online on: October 12, 2012
       https://doi.org/10.3892/mmr.2012.1125
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Abstract

TGF-β1 induces the conversion of CD4+CD25- T cells into CD4+CD25+Foxp3+ regulatory T cells (Tregs). Galectin-9, one of the β-galactoside-binding animal lectins belonging to the galectin family, induces apoptosis of eosinophils, cancer cells and T cells. In this study, we report the effects of galectin-9 on the conversion of CD4+CD25- T cells into Foxp3-expressing induced Tregs (iTregs). Galectin-9 together with TGF-β1 had synergistic effects on the rate of conversion to iTregs in vitro. TGF-β1 signaling appears to be essential for the effects of galectin-9 on the generation of iTregs, as galectin-9 promotes TGF-β1-induced phosphorylation of Smad2/3, ERK1/2 and formation of the Smad2/3-Smad4 complex. These data suggest a role for galectin-9 as a promoter of the TGF-β1-dependent conversion of CD4+CD25- T cells into iTregs in vitro. Therefore, in addition to inducing apoptosis, galectin-9 may contribute to the regulation of inflammation via the expansion of peripheral Tregs.
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Copy and paste a formatted citation
Spandidos Publications style
Lv K, Zhang Y, Zhang M, Zhong M and Suo Q: Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway. Mol Med Rep 7: 205-210, 2013.
APA
Lv, K., Zhang, Y., Zhang, M., Zhong, M., & Suo, Q. (2013). Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway. Molecular Medicine Reports, 7, 205-210. https://doi.org/10.3892/mmr.2012.1125
MLA
Lv, K., Zhang, Y., Zhang, M., Zhong, M., Suo, Q."Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway". Molecular Medicine Reports 7.1 (2013): 205-210.
Chicago
Lv, K., Zhang, Y., Zhang, M., Zhong, M., Suo, Q."Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway". Molecular Medicine Reports 7, no. 1 (2013): 205-210. https://doi.org/10.3892/mmr.2012.1125
Copy and paste a formatted citation
x
Spandidos Publications style
Lv K, Zhang Y, Zhang M, Zhong M and Suo Q: Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway. Mol Med Rep 7: 205-210, 2013.
APA
Lv, K., Zhang, Y., Zhang, M., Zhong, M., & Suo, Q. (2013). Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway. Molecular Medicine Reports, 7, 205-210. https://doi.org/10.3892/mmr.2012.1125
MLA
Lv, K., Zhang, Y., Zhang, M., Zhong, M., Suo, Q."Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway". Molecular Medicine Reports 7.1 (2013): 205-210.
Chicago
Lv, K., Zhang, Y., Zhang, M., Zhong, M., Suo, Q."Galectin-9 promotes TGF-β1-dependent induction of regulatory T cells via the TGF-β/Smad signaling pathway". Molecular Medicine Reports 7, no. 1 (2013): 205-210. https://doi.org/10.3892/mmr.2012.1125
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