Detection of IL-6 by magnetic nanoparticles grown with the assistance of mid-infrared lighting

Jiang,Xiufeng; Zhang,Ye; Miao,Xiaofei; Li,Zenghui; Bao,Zengtao; Wang,Tong

doi:10.3892/mmr.2012.1136

January 2013 Volume 7 Issue 1

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January 2013 Volume 7 Issue 1

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Article

Detection of IL-6 by magnetic nanoparticles grown with the assistance of mid-infrared lighting

Authors:
- Xiufeng Jiang
- Ye Zhang
- Xiaofei Miao
- Zenghui Li
- Zengtao Bao
- Tong Wang
View Affiliations / Copyright

Affiliations: Department of General Surgery, Wuxi People's Hospital, Wuxi, Jiangsu 214023, P.R. China
Pages: 73-76
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Published online on: October 19, 2012

https://doi.org/10.3892/mmr.2012.1136
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Abstract

Nanomedical systems have attracted considerable attention primarily due to suitability in applications for specific cell selection through biomolecular targeting and rare cell detection enhancement in a diverse, multicellular population. In the present study, magnetic nanoparticles were prepared for use in high accuracy cell sensing. Magnetic nanoparticle growth was assisted by mid-infrared lighting. By this mechanism, a narrow window, estimated to be 2%, was achieved for the dimension distribution of grown nanoparticles. Combined with silicon nanowire (SiNW) transistors, a sensor with ultra high sensitivity for the detection of specific potential low abundance biomarkers has been achieved, which has been specifically used to detect interleukin-6 (IL-6) at extremely low concentrations. A novel biosensor with high sensitivity has been fabricated and utilized in the detection of IL-6 at 75 fM to 50 pM. The system consists of an SiNW transistor and magnetic nanoparticles with even dimension distribution. The novel sensor system is suitable for quantifying IL-6 at low concentrations in protein samples.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Detection of IL-6 by magnetic nanoparticles grown with the assistance of mid-infrared lighting

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Abstract

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