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Article

Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension

  • Authors:
    • Jinrui Fang
    • Liya Ma
    • Shuhong Zhang
    • Yan Fang
    • Peng Su
    • Huiyuan Ma
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Third Ward of Cadre, People's Hospital of Gansu Province, Lanzhou, Gansu 730000, P.R. China, Women's Secondary School of Gansu Province, Lanzhou, Gansu 730000, P.R. China
  • Pages: 313-317
    |
    Published online on: October 23, 2012
       https://doi.org/10.3892/mmr.2012.1143
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Abstract

The aim of this study was to investigate the association between myeloperoxidase (MPO) gene polymorphisms and carotid atherosclerosis (AS) in patients with essential hypertension (EH). A total of 214 patients with EH were divided into an AS and a non-atherosclerosis (non-AS) group. MPO gene polymorphisms in EH were detected using PCR. The frequency of increased intima-media thickness and the occurrence of plaque in the carotid artery in the AS group was higher compared to the non-AS group. The frequency of the GC genotype in the AS group was significantly higher compared to the non-AS group. The frequency of carotid AS is higher in patients with hypertension, which is related to the MPO gene polymorphism.
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Copy and paste a formatted citation
Spandidos Publications style
Fang J, Ma L, Zhang S, Fang Y, Su P and Ma H: Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension. Mol Med Rep 7: 313-317, 2013.
APA
Fang, J., Ma, L., Zhang, S., Fang, Y., Su, P., & Ma, H. (2013). Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension. Molecular Medicine Reports, 7, 313-317. https://doi.org/10.3892/mmr.2012.1143
MLA
Fang, J., Ma, L., Zhang, S., Fang, Y., Su, P., Ma, H."Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension". Molecular Medicine Reports 7.1 (2013): 313-317.
Chicago
Fang, J., Ma, L., Zhang, S., Fang, Y., Su, P., Ma, H."Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension". Molecular Medicine Reports 7, no. 1 (2013): 313-317. https://doi.org/10.3892/mmr.2012.1143
Copy and paste a formatted citation
x
Spandidos Publications style
Fang J, Ma L, Zhang S, Fang Y, Su P and Ma H: Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension. Mol Med Rep 7: 313-317, 2013.
APA
Fang, J., Ma, L., Zhang, S., Fang, Y., Su, P., & Ma, H. (2013). Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension. Molecular Medicine Reports, 7, 313-317. https://doi.org/10.3892/mmr.2012.1143
MLA
Fang, J., Ma, L., Zhang, S., Fang, Y., Su, P., Ma, H."Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension". Molecular Medicine Reports 7.1 (2013): 313-317.
Chicago
Fang, J., Ma, L., Zhang, S., Fang, Y., Su, P., Ma, H."Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension". Molecular Medicine Reports 7, no. 1 (2013): 313-317. https://doi.org/10.3892/mmr.2012.1143
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