Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus

  • Authors:
    • Yujuan Zhu
    • Daming Deng
    • Chongde Long
    • Guorong Jin
    • Qingjiong Zhang
    • Huangxuan Shen
  • View Affiliations

  • Published online on: October 24, 2012     https://doi.org/10.3892/mmr.2012.1149
  • Pages: 217-222
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Abstract

Hyperplasia or hypoplasia of muscles gradually leads to strabismus. Myogenesis-related genes are involved in extraocular muscle development, including myogenic differentiation 1 (MYOD1), myogenin (MYOG), retinoblastoma 1 (RB1), cyclin-dependent kinase inhibitor 1A (P21), cyclin‑dependent kinase inhibitor 1C (P57), insulin-like growth factor 1 (IGF1) and muscle creatine kinase (MCK). This study evaluated the expression of the above seven myogenesis-related genes by real-time quantitative RT-PCR in 18 resected extrocular muscles of patients with concomitant strabismus and 12 normal control muscle samples from one presumably healthy male 6 h after sudden mortality. We found that although there was a great divergence among the expression levels of 6 myogenesis-related regulatory factors, the relative expression patterns were similar in all the normal muscles, including the synergistic, antagonistic and yoke muscles. However, their expression levels in the 18 diseased extraocular muscles were abnormal; the expression levels of all the genes, with the exception of P57, were reduced in most of the diseased muscle tissues. These results imply that the abnormal expression of these myogenesis-related genes may contribute to concomitant strabismus.
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January 2013
Volume 7 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu Y, Deng D, Long C, Jin G, Zhang Q and Shen H: Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus. Mol Med Rep 7: 217-222, 2013
APA
Zhu, Y., Deng, D., Long, C., Jin, G., Zhang, Q., & Shen, H. (2013). Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus. Molecular Medicine Reports, 7, 217-222. https://doi.org/10.3892/mmr.2012.1149
MLA
Zhu, Y., Deng, D., Long, C., Jin, G., Zhang, Q., Shen, H."Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus". Molecular Medicine Reports 7.1 (2013): 217-222.
Chicago
Zhu, Y., Deng, D., Long, C., Jin, G., Zhang, Q., Shen, H."Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus". Molecular Medicine Reports 7, no. 1 (2013): 217-222. https://doi.org/10.3892/mmr.2012.1149