Epidemiology and resistance mechanisms to imipenem in Klebsiella pneumoniae: A multicenter study

Chen,Huihong; Yuehua,Xue; Shen,Weiwei; Zhou,Hua; Zhou,Lizhong; Li,Zhaoyun

doi:10.3892/mmr.2012.1155

January 2013 Volume 7 Issue 1

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January 2013 Volume 7 Issue 1

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Article Open Access

Epidemiology and resistance mechanisms to imipenem in Klebsiella pneumoniae: A multicenter study

Authors:
- Huihong Chen
- Xue Yuehua
- Weiwei Shen
- Hua Zhou
- Lizhong Zhou
- Zhaoyun Li
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Affiliations: Department of Clinical Laboratory, Central Hospital of Taizhou City, Taizhou, Zhejiang, P.R. China, Department of Brain Surgery, Central Hospital of Taizhou City, Taizhou, Zhejiang, P.R. China, Disease Control Center of Taizhou City, Taizhou, Zhejiang, P.R. China, Department of Infectious Diseases, First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, P.R. China , Clinical Laboratory, Shanghai Ruijin Hospital, Shanghai, P.R. China

Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
Pages: 21-25
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Published online on: October 25, 2012

https://doi.org/10.3892/mmr.2012.1155
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Abstract

Four clinical isolates of imipenem-resistant Klebsiella pneumoniae were isolated from clinical patient specimens and from samples obtained from hygienic surveillance in our hospital. We examined their minimum inhibitory concentration (MIC) to various types of antibiotics, detected the carbapenemases by a modified Hodge test and analyzed the genotype and homogeneity. The enzyme, Klebsiella pneumoniae carbapenemase (KPC)-2, was detected in all four isolates and this was the main cause of their imipenem resistance. In addition, these four isolates also contained the extended-spectrum β-lactamase (ESBL) gene blaCTX-M-9 and the cephalosporinase (AmpC) gene blaDHA-1, which resulted in multidrug resistance.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Epidemiology and resistance mechanisms to imipenem in Klebsiella pneumoniae: A multicenter study

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