Expression and the clinical significance of hPTTG1 in gastric cancer

Luo,Zuyan; Li,Bo; Chen,Junfa; Ma,Yingyu; Tao,Houquan

doi:10.3892/mmr.2012.1161

January 2013 Volume 7 Issue 1

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January 2013 Volume 7 Issue 1

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Article

Expression and the clinical significance of hPTTG1 in gastric cancer

Authors:
- Zuyan Luo
- Bo Li
- Junfa Chen
- Yingyu Ma
- Houquan Tao
View Affiliations / Copyright

Affiliations: Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, P.R. China, Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, P.R. China
Pages: 43-46
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Published online on: November 1, 2012

https://doi.org/10.3892/mmr.2012.1161
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Abstract

The aim of this study was to investigate the expression and clinical significance of hPTTG1 in gastric cancer. Immunohistochemistry was performed to determine the expression of hPTTG1 in gastric cancer tissues. Results showed that the positive expression of hPTTG1 in gastric cancer tissues was 60.00%, while in adjacent normal tissues it was 17.78%. The expression of hPTTG1 was correlated with differentiation levels, clinical classification and lymph node metastasis, but did not correlate with gender, age or pathological types. hPTTG1 was, therefore, overexpressed in gastric cancer tissues. The progression of gastric cancer was found to be correlated with the upregulation of the expression of hPTTG1. hPTTG1 detection may be helpful in evaluating the ability of the clinical classification and lymph node metastasis in gastric cancer to predict outcomes. These factors act as indicators of the biological behavior of gastric cancer and are fairly good markers for prognosis and therapy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression and the clinical significance of hPTTG1 in gastric cancer

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Abstract

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