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Article

Role of CYP1A2 polymorphisms in breast cancer risk in women

  • Authors:
    • Imene Ayari
    • Ugo Fedeli
    • Saad Saguem
    • Samir Hidar
    • Saida Khlifi
    • Sofia Pavanello
  • View Affiliations / Copyright

    Affiliations: Metabolic Biophysics and Applied Pharmacology Laboratory, Department of Biophysics, University of Sousse, Sousse 4002, Tunisia, Epidemiologic System Veneto Region (SER), I-35131 Padova, Italy, Department of Gynecology‑Obstetrics, Hospital Farhat Hached, University of Sousse, Sousse 4002, Tunisia, Occupational Health Section, Department of Cardiological, Thoracic and Vascular Sciences, University of Padova, I-35128 Padova, Italy
  • Pages: 280-286
    |
    Published online on: November 1, 2012
       https://doi.org/10.3892/mmr.2012.1164
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Abstract

Cytochrome P4501A2 (CYP1A2) is a key enzyme in the etiology of breast cancer (BC). It is involved in breast carcinogen activation [aromatic (AAs) and heterocyclic amines (HAs), polycyclic aromatic hydrocarbons (PAHs)], in the production of beneficial oestrogen [2-hydroxyestrone (2-OHE1)] and in converting arachidonic acid (AAc) to epoxyeicosatrienoic acids (EETs), which have anti-inflammatory properties. Within a hospital-based case-control study, the effect of functional CYP1A2 variants [-3860G/A (rs2069514), -2467T/delT (rs3569413), -163C/A (rs762551)] and their interactions with environmental factors in BC risk was investigated. The study population included 125 BC cases and 43 non-cancer controls. Genotyping was performed in RT-PCR using Taqman assays. The gene-environment interaction was appraised using a case-only study design. We found that the -3860A variant, independently from environmental factors, as well as by interacting with fried foods (p=0.025) and indoor exposure to pollutants (p=0.050), reduced the risk of BC (p=0.025), whereas its interaction with coffee (p=0.045) increased the BC risk. This is the first study indicating that the -3860A variant, by decreasing CYP1A2 activity, modifies BC risk by interacting with environmental factors, thereby supporting the hypothesis that reduced CYP1A2 activity contributes to BC risk in different ways, for example, it may be protective by reducing the activation of pro-carcinogens such as AAs, HAs and PAHs, but would increase risk by reducing the beneficial formation of 2-OHE1 and EETs.
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Copy and paste a formatted citation
Spandidos Publications style
Ayari I, Fedeli U, Saguem S, Hidar S, Khlifi S and Pavanello S: Role of CYP1A2 polymorphisms in breast cancer risk in women. Mol Med Rep 7: 280-286, 2013.
APA
Ayari, I., Fedeli, U., Saguem, S., Hidar, S., Khlifi, S., & Pavanello, S. (2013). Role of CYP1A2 polymorphisms in breast cancer risk in women. Molecular Medicine Reports, 7, 280-286. https://doi.org/10.3892/mmr.2012.1164
MLA
Ayari, I., Fedeli, U., Saguem, S., Hidar, S., Khlifi, S., Pavanello, S."Role of CYP1A2 polymorphisms in breast cancer risk in women". Molecular Medicine Reports 7.1 (2013): 280-286.
Chicago
Ayari, I., Fedeli, U., Saguem, S., Hidar, S., Khlifi, S., Pavanello, S."Role of CYP1A2 polymorphisms in breast cancer risk in women". Molecular Medicine Reports 7, no. 1 (2013): 280-286. https://doi.org/10.3892/mmr.2012.1164
Copy and paste a formatted citation
x
Spandidos Publications style
Ayari I, Fedeli U, Saguem S, Hidar S, Khlifi S and Pavanello S: Role of CYP1A2 polymorphisms in breast cancer risk in women. Mol Med Rep 7: 280-286, 2013.
APA
Ayari, I., Fedeli, U., Saguem, S., Hidar, S., Khlifi, S., & Pavanello, S. (2013). Role of CYP1A2 polymorphisms in breast cancer risk in women. Molecular Medicine Reports, 7, 280-286. https://doi.org/10.3892/mmr.2012.1164
MLA
Ayari, I., Fedeli, U., Saguem, S., Hidar, S., Khlifi, S., Pavanello, S."Role of CYP1A2 polymorphisms in breast cancer risk in women". Molecular Medicine Reports 7.1 (2013): 280-286.
Chicago
Ayari, I., Fedeli, U., Saguem, S., Hidar, S., Khlifi, S., Pavanello, S."Role of CYP1A2 polymorphisms in breast cancer risk in women". Molecular Medicine Reports 7, no. 1 (2013): 280-286. https://doi.org/10.3892/mmr.2012.1164
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