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Article

MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma

  • Authors:
    • Si-Hong You
    • Xiang Wang
    • Shu Huang
    • Min Wang
    • Guo-Zhong Ji
    • Jin-Rong Xia
    • Zhi-Ning Fan
  • View Affiliations / Copyright

    Affiliations: Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, P.R. China, Department of Gastroenterology, ZhongDa Hospital, Southeast University, Nanjing 210009, P.R. China
  • Pages: 347-351
    |
    Published online on: November 8, 2012
       https://doi.org/10.3892/mmr.2012.1175
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Abstract

Cholangiocarcinoma (CCA) is a rare but devastating malignancy. Up to 90% of patients presenting with CCA have no identifiable risk factors. The base excision repair (BER) pathway has a principal role in the repair of mutations caused by oxidized or reduced bases. The MutY homolog (MUTYH, MYH) is one of the key proteins in the BER pathway, but the role of MYH in the tumorigenesis of CCA is largely unknown. In this study, we investigated the influence of MYH rs3219476 and rs3219472 polymorphisms on CCA incidence. MYH genotypes were detected using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. We found that for rs3219472, compared with subjects carrying the MYH G/G genotype, those with the A/A genotype had a 2.816-fold higher risk of CCA [odds ratio (OR)=2.816, 95% confidence interval (CI)=0.992-7.999, P=0.047). For rs3219476, compared with subjects carrying the MYH T/T genotype, those with the T/G genotype had a reduced risk of CCA (OR=0.359, 95% CI=0.17-0.758, P=0.006). Our findings suggest that since significantly increased CCA risk was found in individuals with a homozygous variant genotype for rs3219472, it may be a biomarker for screening individuals at high risk of developing the disease.
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Copy and paste a formatted citation
Spandidos Publications style
You S, Wang X, Huang S, Wang M, Ji G, Xia J and Fan Z: MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma. Mol Med Rep 7: 347-351, 2013.
APA
You, S., Wang, X., Huang, S., Wang, M., Ji, G., Xia, J., & Fan, Z. (2013). MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma. Molecular Medicine Reports, 7, 347-351. https://doi.org/10.3892/mmr.2012.1175
MLA
You, S., Wang, X., Huang, S., Wang, M., Ji, G., Xia, J., Fan, Z."MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma". Molecular Medicine Reports 7.1 (2013): 347-351.
Chicago
You, S., Wang, X., Huang, S., Wang, M., Ji, G., Xia, J., Fan, Z."MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma". Molecular Medicine Reports 7, no. 1 (2013): 347-351. https://doi.org/10.3892/mmr.2012.1175
Copy and paste a formatted citation
x
Spandidos Publications style
You S, Wang X, Huang S, Wang M, Ji G, Xia J and Fan Z: MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma. Mol Med Rep 7: 347-351, 2013.
APA
You, S., Wang, X., Huang, S., Wang, M., Ji, G., Xia, J., & Fan, Z. (2013). MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma. Molecular Medicine Reports, 7, 347-351. https://doi.org/10.3892/mmr.2012.1175
MLA
You, S., Wang, X., Huang, S., Wang, M., Ji, G., Xia, J., Fan, Z."MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma". Molecular Medicine Reports 7.1 (2013): 347-351.
Chicago
You, S., Wang, X., Huang, S., Wang, M., Ji, G., Xia, J., Fan, Z."MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma". Molecular Medicine Reports 7, no. 1 (2013): 347-351. https://doi.org/10.3892/mmr.2012.1175
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