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Article

The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence

Corrigendum in: /10.3892/mmr.2023.13069
  • Authors:
    • Dan Peng
    • Houjuan Zuo
    • Zhengxiang Liu
    • Jin Qin
    • Yuanlin Zhou
    • Pengcheng Li
    • Daowen Wang
    • Hesong Zeng
    • Xin A. Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R.China, Department of Cardiology of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R.China, Department of Physiology and Cancer Center, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
  • Pages: 836-842
    |
    Published online on: December 24, 2012
       https://doi.org/10.3892/mmr.2012.1250
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Abstract

Previous studies have shown that the tetraspanin CD151 is essential for pathological or physiological angiogenesis. However, the cellular signaling mechanism and the role of the CD151 YRSL sorting motif in in vitro vasculogenesis remains unknown. In this study, the results showed that both CD151 and CD151-ARSA gene delivery were capable of increasing the expression of CD151 at the protein level in human umbilical vein endothelial cells (HUVECs). Moreover, there was no significant difference in CD151 protein expression between the CD151 group and the CD151-ARSA group. Overexpression of CD151 promoted HUVEC cell proliferation, migration and capillary network formation in vitro. However, in the CD151-ARSA group, the abilities of cell proliferation, migration and capillary network formation were all decreased, compared with the CD151 group. Furthermore, the activation of PI3K, Akt and ERK signaling pathways was attenuated in the CD151-ARSA mutant group compared with the CD151 group. This study suggests that the YRSL motif of CD151 plays a key role in CD151-induced angiogenesis. Our observations provide insights into a new mechanism of CD151 regulating angiogenesis via vesicle trafficking.
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Copy and paste a formatted citation
Spandidos Publications style
Peng D, Zuo H, Liu Z, Qin J, Zhou Y, Li P, Wang D, Zeng H and Zhang XA: The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069. Mol Med Rep 7: 836-842, 2013.
APA
Peng, D., Zuo, H., Liu, Z., Qin, J., Zhou, Y., Li, P. ... Zhang, X.A. (2013). The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069. Molecular Medicine Reports, 7, 836-842. https://doi.org/10.3892/mmr.2012.1250
MLA
Peng, D., Zuo, H., Liu, Z., Qin, J., Zhou, Y., Li, P., Wang, D., Zeng, H., Zhang, X. A."The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069". Molecular Medicine Reports 7.3 (2013): 836-842.
Chicago
Peng, D., Zuo, H., Liu, Z., Qin, J., Zhou, Y., Li, P., Wang, D., Zeng, H., Zhang, X. A."The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069". Molecular Medicine Reports 7, no. 3 (2013): 836-842. https://doi.org/10.3892/mmr.2012.1250
Copy and paste a formatted citation
x
Spandidos Publications style
Peng D, Zuo H, Liu Z, Qin J, Zhou Y, Li P, Wang D, Zeng H and Zhang XA: The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069. Mol Med Rep 7: 836-842, 2013.
APA
Peng, D., Zuo, H., Liu, Z., Qin, J., Zhou, Y., Li, P. ... Zhang, X.A. (2013). The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069. Molecular Medicine Reports, 7, 836-842. https://doi.org/10.3892/mmr.2012.1250
MLA
Peng, D., Zuo, H., Liu, Z., Qin, J., Zhou, Y., Li, P., Wang, D., Zeng, H., Zhang, X. A."The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069". Molecular Medicine Reports 7.3 (2013): 836-842.
Chicago
Peng, D., Zuo, H., Liu, Z., Qin, J., Zhou, Y., Li, P., Wang, D., Zeng, H., Zhang, X. A."The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence Corrigendum in /10.3892/mmr.2023.13069". Molecular Medicine Reports 7, no. 3 (2013): 836-842. https://doi.org/10.3892/mmr.2012.1250
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