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Article

Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis

  • Authors:
    • Haikuo Tang
    • Zhiyuan Wu
    • Jianping Zhang
    • Bing Su
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxicallifacial Surgery, The Affiliated Stomatology Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510055, P.R. China, Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, P.R. China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Biomedical Research Institute, Shenzhen‑PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China
  • Pages: 761-766
    |
    Published online on: December 28, 2012
       https://doi.org/10.3892/mmr.2012.1254
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Abstract

Oral squamous cell carcinoma (OSCC) is a common and lethal malignancy. Thus, improvement in current knowledge of molecular changes associated with OSCC is urgently needed to explore novel avenues of diagnostics and treatment of this disease. While aberrant expression of long non‑coding RNAs (lncRNAs) has been functionally associated with certain types of cancer, including lung, breast and prostate carcinomas, their expression pattern and biological relevance in OSCC is currently unknown. In the present study, the relative abundance of a collection of lncRNAs in tissue or saliva samples from OSCC patients was investigated. It was shown that subsets of lncRNAs are expressed across non‑tumor, tumor and metastatic tissue samples. Some detected lncRNAs were shown to be aberrantly expressed in cases of oral cancer and metastasis. Moreover, whole saliva contained a detectable amount of some lncRNAs, which appeared to be potential markers for OSCC. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Tang H, Wu Z, Zhang J and Su B: Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Rep 7: 761-766, 2013.
APA
Tang, H., Wu, Z., Zhang, J., & Su, B. (2013). Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Molecular Medicine Reports, 7, 761-766. https://doi.org/10.3892/mmr.2012.1254
MLA
Tang, H., Wu, Z., Zhang, J., Su, B."Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis". Molecular Medicine Reports 7.3 (2013): 761-766.
Chicago
Tang, H., Wu, Z., Zhang, J., Su, B."Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis". Molecular Medicine Reports 7, no. 3 (2013): 761-766. https://doi.org/10.3892/mmr.2012.1254
Copy and paste a formatted citation
x
Spandidos Publications style
Tang H, Wu Z, Zhang J and Su B: Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Rep 7: 761-766, 2013.
APA
Tang, H., Wu, Z., Zhang, J., & Su, B. (2013). Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Molecular Medicine Reports, 7, 761-766. https://doi.org/10.3892/mmr.2012.1254
MLA
Tang, H., Wu, Z., Zhang, J., Su, B."Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis". Molecular Medicine Reports 7.3 (2013): 761-766.
Chicago
Tang, H., Wu, Z., Zhang, J., Su, B."Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis". Molecular Medicine Reports 7, no. 3 (2013): 761-766. https://doi.org/10.3892/mmr.2012.1254
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