The blues of P(16)INK(4a): Aberrant promoter methylation and association with colorectal cancer in the Kashmir valley

  • Authors:
    • A. Syed Sameer
    • Safiya Abdullah
    • Saniya Nissar
    • Roohi Rasool
    • Zaffar A. Shah
    • Dil Afroze
    • Nissar A. Chowdri
    • Mushtaq A. Siddiqi
  • View Affiliations

  • Published online on: January 3, 2012     https://doi.org/10.3892/mmr.2012.740
  • Pages: 1053-1057
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Abstract

Hypermethylation of the promoter region of the p16INK4a (p16) gene plays a significant role in the development and progression of colorectal cancer (CRC). The aim of the present study was to establish the role of the methylation status of the p16 gene in 114 CRC cases and to correlate it with the various clinicopathological parameters. Analysis of p16 promoter methylation was performed by methylation-specific PCR. Forty-eight (42.1%) of the CRC cases were found to be methylated for the p16 gene in our population. The methylation status was found to be associated with the gender, lymph node status, tumour stage, smoking status and tumour grade of the CRC patients. p16 plays a pivotal role in tumour development and progression to advanced stages.
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April 2012
Volume 5 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sameer AS, Abdullah S, Nissar S, Rasool R, Shah ZA, Afroze D, Chowdri NA and Siddiqi MA: The blues of P(16)INK(4a): Aberrant promoter methylation and association with colorectal cancer in the Kashmir valley. Mol Med Rep 5: 1053-1057, 2012
APA
Sameer, A.S., Abdullah, S., Nissar, S., Rasool, R., Shah, Z.A., Afroze, D. ... Siddiqi, M.A. (2012). The blues of P(16)INK(4a): Aberrant promoter methylation and association with colorectal cancer in the Kashmir valley. Molecular Medicine Reports, 5, 1053-1057. https://doi.org/10.3892/mmr.2012.740
MLA
Sameer, A. S., Abdullah, S., Nissar, S., Rasool, R., Shah, Z. A., Afroze, D., Chowdri, N. A., Siddiqi, M. A."The blues of P(16)INK(4a): Aberrant promoter methylation and association with colorectal cancer in the Kashmir valley". Molecular Medicine Reports 5.4 (2012): 1053-1057.
Chicago
Sameer, A. S., Abdullah, S., Nissar, S., Rasool, R., Shah, Z. A., Afroze, D., Chowdri, N. A., Siddiqi, M. A."The blues of P(16)INK(4a): Aberrant promoter methylation and association with colorectal cancer in the Kashmir valley". Molecular Medicine Reports 5, no. 4 (2012): 1053-1057. https://doi.org/10.3892/mmr.2012.740