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Article

The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation

  • Authors:
    • Dae-Weon Park
    • Hyung-Kyoung Lee
    • Tae-Whal Jeong
    • Jin-Sik Kim
    • Yoe-Sik Bae
    • Byung-Rho Chin
    • Suk-Hwan Baek
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Aging-associated Vascular Disease Research Center, 210 Main Building, College of Medicine, Yeungnam University, Daegu 705-802, Republic of Korea, Department of Dentistry, College of Medicine, Yeungnam University, Daegu 705-802, Republic of Korea, Department of Biological Science, Sungkyunkwan University, Suwon 440-746, Republic of Korea, Department of Biochemistry and Molecular Biology, Aging-associated Vascular Disease Research Center, 210 Main Building, College of Medicine, Yeungnam University, Daegu 705-802, Republic of Korea
  • Pages: 1063-1067
    |
    Published online on: January 3, 2012
       https://doi.org/10.3892/mmr.2012.741
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Abstract

Monocyte chemoattractant protein-1 (MCP-1) is an essential cytokine for the migration of monocytes into vessels, and is also involved in the pathogenesis of atherosclerosis. In this study, we investigated the importance of janus kinase 2 (JAK2) and the function of the Akt and glycogen synthase kinase-3β (GSK3β) pathway in toll-like receptor (TLR2)-mediated MCP-1 expression. The TLR2 agonist, Pam3CSK4, induced MCP-1 expression in the Raw264.7 cell line. The induction of MCP-1 was seen in the bone marrow-derived macrophages of wild-type mice but not in TLR2 knockout mice. The TLR2-mediated MCP-1 induction was myeloid differentiation primary response gene 88 (MyD88)-independent. By contrast, the inactivation of JAK2 attenuated TLR2-mediated MCP-1 expression. The JAK inhibitor suppressed the phosphorylation of GSK3β as well as Akt by Pam3CSK4 stimulation. While the inactivation of Akt by LY294002 suppressed TLR2-mediated MCP-1 induction, the inactivation of GSK3β by LiCl potentiated TLR2-mediated MCP-1 induction. Furthermore, Akt inhibitor suppressed TLR2-mediated phosphorylation of GSK3β. Taken together, these results suggest that a MyD88-independent pathway exists in TLR2 signaling; the JAK2-Akt-GSK3β pathway is a novel MyD88-independent pathway for MCP-1 induction.
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1 

A MencinJ KluweRF SchwabeToll-like receptors as targets in chronic liver diseasesGut58704720200910.1136/gut.2008.15630719359436

2 

S AkiraToll-like receptor signalingJ Biol Chem2783810538108200310.1074/jbc.R30002820012893815

3 

S FrantzG ErtlJ BauersachsMechanisms of disease: Toll-like receptors in cardiovascular diseaseNat Clin Pract Cardiovasc Med4444454200710.1038/ncpcardio093817653117

4 

S AkiraS UematsuO TakeuchiPathogen recognition and innate immunityCell124783801200610.1016/j.cell.2006.02.01516497588

5 

JY KangX NanMS JinRecognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimerImmunity31873884200910.1016/j.immuni.2009.09.01819931471

6 

AH SchoneveldI HoeferJP SluijterJD LamanDP de KleijnG PasterkampAtherosclerotic lesion development and Toll like receptor 2 and 4 responsivenessAtherosclerosis19795104200810.1016/j.atherosclerosis.2007.08.00417888930

7 

X LiuT UkaiH YumotoToll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipidsAtherosclerosis196146154200810.1016/j.atherosclerosis.2007.03.02517466307

8 

AE MullickPS TobiasLK CurtissModulation of atherosclerosis in mice by Toll-like receptor 2J Clin Invest11531493156200510.1172/JCI2548216211093

9 

S KuwahataS FujitaK OriharaHigh expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic diseaseAtherosclerosis209248254201010.1016/j.atherosclerosis.2009.08.04619766998

10 

C MonacoN TerrandoKS MidwoodToll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritisArthritis Care Res (Hoboken)63500511201110.1002/acr.2038221452263

11 

AE MullickK SoldauWB KiossesTA Bell IIIPS TobiasLK CurtissIncreased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic eventsJ Exp Med205373383200810.1084/jem.2007109618250194

12 

Y AbeA KawakamiM OsakaApolipoprotein CIII induces monocyte chemoattractant protein-1 and interleukin 6 expression via Toll-like receptor 2 pathway in mouse adipocytesArterioscler Thromb Vasc Biol3022422248201010.1161/ATVBAHA.110.210427

13 

F CaoA CastrilloP TontonozF ReGI ByrneChlamydia pneumoniae-induced macrophage foam cell formation is mediated by Toll-like receptor 2Infect Immun75753759200710.1128/IAI.01386-06

14 

A ZerneckeE ShagdarsurenC WeberChemokines in atherosclerosis: an updateArterioscler Thromb Vasc Biol2818971908200810.1161/ATVBAHA.107.161174

15 

RR KoenenC WeberTherapeutic targeting of chemokine interactions in atherosclerosisNat Rev Drug Discov9141153201010.1038/nrd304820118962

16 

CW NiDL WangSC LienJJ ChengYJ ChaoHJ HsiehActivation of PKC-epsilon and ERK1/2 participates in shear-induced endothelial MCP-1 expression that is repressed by nitric oxideJ Cell Physiol195428434200310.1002/jcp.1025912704652

17 

PG ArndtN SuzukiNJ AvdiKC MalcolmGS WorthenLipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathwaysJ Biol Chem2791088310891200410.1074/jbc.M30990120014699155

18 

DW ParkK BaekJR KimResveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1Exp Mol Med41171179200910.3858/emm.2009.41.3.02019293636

19 

CS TsaiFY LinYH ChenCilostazol attenuates MCP-1 and MMP-9 expression in vivo in LPS-administrated balloon-injured rabbit aorta and in vitro in LPS-treated monocytic THP-1 cellsJ Cell Biochem1035466200810.1002/jcb.2138817516547

20 

JG LeeSH LeeDW ParkToll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signalingCell Signal20105111200810.1016/j.cellsig.2007.09.00317939949

21 

V BraunersreutherF MachS SteffensThe specific role of chemokines in atherosclerosisThromb Haemost97714721200717479181

22 

R AhmadS El BassamP CordeiroJ MenezesRequirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1Blood11223602368200810.1182/blood-2008-02-13771118583567

23 

JE ParkYI KimAK YiProtein kinase D1 is essential for MyD88-dependent TLR signaling pathwayJ Immunol18263166327200910.4049/jimmunol.080423919414785

24 

S ChenR SorrentinoK ShimadaChlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activationJ Immunol18171867193200810.4049/jimmunol.181.10.7186

25 

S OkugawaY OtaT KitazawaJanus kinase 2 is involved in lipopolysaccharide-induced activation of macrophagesAm J Physiol Cell Physiol285C399C408200310.1152/ajpcell.00026.200312686512

26 

K KamezakiK ShimodaA NumataT MatsudaK NakayamaM HaradaThe role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signalsInt Immunol1611731179200410.1093/intimm/dxh11815226272

27 

S RebouissouM AmessouG CouchyFrequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumoursNature457200204200910.1038/nature07475

28 

R RosellJ Bertran-AlamilloMA MolinaM TaronIL-6/gp130/STAT3 signaling axis in cancer and the presence of in-frame gp130 somatic deletions in inflammatory hepatocellular tumorsFuture Oncol5305308200910.2217/fon.09.319374537

29 

IT LeeCW LeeWH TungCooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responsesAm J Pathol17616711684201010.2353/ajpath.2010.09071420167866

30 

GT BrownTM McIntyreLipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1beta-rich microparticlesJ Immunol18654895496201110.4049/jimmunol.100162321430222

31 

N HirataY YanagawaK IwabuchiK OnoeSelective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cellsCell Immunol258917200910.1016/j.cellimm.2009.03.00619361784

32 

M MartinK RehaniRS JopeSM MichalekToll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3Nat Immunol6777784200510.1038/ni122116007092

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Copy and paste a formatted citation
Spandidos Publications style
Park D, Lee H, Jeong T, Kim J, Bae Y, Chin B and Baek S: The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation. Mol Med Rep 5: 1063-1067, 2012.
APA
Park, D., Lee, H., Jeong, T., Kim, J., Bae, Y., Chin, B., & Baek, S. (2012). The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation. Molecular Medicine Reports, 5, 1063-1067. https://doi.org/10.3892/mmr.2012.741
MLA
Park, D., Lee, H., Jeong, T., Kim, J., Bae, Y., Chin, B., Baek, S."The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation". Molecular Medicine Reports 5.4 (2012): 1063-1067.
Chicago
Park, D., Lee, H., Jeong, T., Kim, J., Bae, Y., Chin, B., Baek, S."The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation". Molecular Medicine Reports 5, no. 4 (2012): 1063-1067. https://doi.org/10.3892/mmr.2012.741
Copy and paste a formatted citation
x
Spandidos Publications style
Park D, Lee H, Jeong T, Kim J, Bae Y, Chin B and Baek S: The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation. Mol Med Rep 5: 1063-1067, 2012.
APA
Park, D., Lee, H., Jeong, T., Kim, J., Bae, Y., Chin, B., & Baek, S. (2012). The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation. Molecular Medicine Reports, 5, 1063-1067. https://doi.org/10.3892/mmr.2012.741
MLA
Park, D., Lee, H., Jeong, T., Kim, J., Bae, Y., Chin, B., Baek, S."The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation". Molecular Medicine Reports 5.4 (2012): 1063-1067.
Chicago
Park, D., Lee, H., Jeong, T., Kim, J., Bae, Y., Chin, B., Baek, S."The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation". Molecular Medicine Reports 5, no. 4 (2012): 1063-1067. https://doi.org/10.3892/mmr.2012.741
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