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Article

Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance

  • Authors:
    • Yi Zhang
    • Nan Lu
    • Yuwen Xue
    • Min Zhang
    • Yingjie Li
    • Yuanquan Si
    • Xiaokun Bian
    • Yanfei Jia
    • Yunshan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory Medicine, Qilu Hospital of Shandong University, Jinan 250012, P.R. China, Institute of Diagnostics, School of Medicine, Shandong University, Jinan 250012, P.R. China, Department of Medicine, Qilu Hospital of Shandong University, Jinan 250012, P.R. China, Department of Medicine, Shandong Chest Hospital, Jinan 250012, P.R. China, Medical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, P.R. China
  • Pages: 910-916
    |
    Published online on: January 9, 2012
       https://doi.org/10.3892/mmr.2012.744
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Abstract

Immune inhibitory receptors play an important role in organ transplantation, autoimmune diseases and cancers. Immunoglobulin-like transcript (ILT)2 and ILT3 belong to the inhibitory receptors of the ILT family, which have been reported to regulate a broad range of cellular functions involved in the immune response. They contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which are related to immune regulation. Although ILT receptors have been studied in dendritic cells (DCs), T cells, NK cells and other cell types, the expression and clinical significance of ILT2 and ILT3 in gastric cancer have yet to be elucidated. Here, the expression of ILT2 and ILT3 in gastric cancer cell lines and pathologic tissues, as well as their effects on the cytotoxicity of NK92MI against the gastric cancer cell lines MKNI with ILT2lowILT3low and HGC-27 with ILT2highILT3high were detected. The results suggest that ILT2 and ILT3 are expressed with diverse degrees in gastric cancer cells and tissues, and the expression of ILT2 is related with differentiation and size of tumors. Furthermore, the cytotoxic activity of NK92MI against the MKNI cell line was stronger than that against HGC-27. This study indicates that ILT2 and ILT3 play a key role in gastric cancer immune escape, and ILT2 may be a new target in the clinical diagnosis and treatment of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Lu N, Xue Y, Zhang M, Li Y, Si Y, Bian X, Jia Y and Wang Y: Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance. Mol Med Rep 5: 910-916, 2012.
APA
Zhang, Y., Lu, N., Xue, Y., Zhang, M., Li, Y., Si, Y. ... Wang, Y. (2012). Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance. Molecular Medicine Reports, 5, 910-916. https://doi.org/10.3892/mmr.2012.744
MLA
Zhang, Y., Lu, N., Xue, Y., Zhang, M., Li, Y., Si, Y., Bian, X., Jia, Y., Wang, Y."Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance". Molecular Medicine Reports 5.4 (2012): 910-916.
Chicago
Zhang, Y., Lu, N., Xue, Y., Zhang, M., Li, Y., Si, Y., Bian, X., Jia, Y., Wang, Y."Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance". Molecular Medicine Reports 5, no. 4 (2012): 910-916. https://doi.org/10.3892/mmr.2012.744
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Lu N, Xue Y, Zhang M, Li Y, Si Y, Bian X, Jia Y and Wang Y: Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance. Mol Med Rep 5: 910-916, 2012.
APA
Zhang, Y., Lu, N., Xue, Y., Zhang, M., Li, Y., Si, Y. ... Wang, Y. (2012). Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance. Molecular Medicine Reports, 5, 910-916. https://doi.org/10.3892/mmr.2012.744
MLA
Zhang, Y., Lu, N., Xue, Y., Zhang, M., Li, Y., Si, Y., Bian, X., Jia, Y., Wang, Y."Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance". Molecular Medicine Reports 5.4 (2012): 910-916.
Chicago
Zhang, Y., Lu, N., Xue, Y., Zhang, M., Li, Y., Si, Y., Bian, X., Jia, Y., Wang, Y."Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance". Molecular Medicine Reports 5, no. 4 (2012): 910-916. https://doi.org/10.3892/mmr.2012.744
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