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Molecular Medicine Reports
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April 2012 Volume 5 Issue 4

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Article

Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma

  • Authors:
    • Bei-Ji Lu
    • Yun-Qing Wang
    • Xue-Jie Wei
    • Liang-Qun Rong
    • Dong Wei
    • Chang-Ming Yan
    • Deng-Jie Wang
    • Jun-Ying Sun
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Orthopedics, the Second Affiliated Hospital, Xuzhou Medical College, Xuzhou, Jiangsu 221000, P.R. China
  • Pages: 1033-1036
    |
    Published online on: January 30, 2012
       https://doi.org/10.3892/mmr.2012.772
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Abstract

Osteosarcoma, a common malignancy primarily affecting children, generally has a poor prognosis. Novel diagnostic, prognostic and therapeutic markers are required to ameliorate the negative outcomes of this disease. We investigated two potential markers, WNT-5a and ROR2, which are hypothesized to dysregulate WNT signaling pathways to promote tumorigenesis in other types of cancer. We investigated WNT-5a and ROR2 expression using immunohistochemistry in 42 osteosarcoma and 12 osteochondroma specimens, and compared the expression of these proteins with one another as well as with clinicopathological parameters. WNT-5a was detected in 34/42 (81.0%) cases and ROR2 was detected in 31/42 (73.8%) cases, significantly higher than in osteochondroma (16.7 and 25.0%, respectively; both P<0.05). Expression of these proteins was positively correlated (r=0.552, P<0.05). Furthermore, expression of WNT-5a and ROR2 was both correlated with Enneking surgical stage and tumor metastasis (P<0.05), but not with patient gender, age or pathological type. Thus, WNT-5a and ROR2 were more highly expressed in more severe disease states, and therefore may play a coordinated role in the occurrence and progression of osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Lu B, Wang Y, Wei X, Rong L, Wei D, Yan C, Wang D and Sun J: Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Mol Med Rep 5: 1033-1036, 2012.
APA
Lu, B., Wang, Y., Wei, X., Rong, L., Wei, D., Yan, C. ... Sun, J. (2012). Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Molecular Medicine Reports, 5, 1033-1036. https://doi.org/10.3892/mmr.2012.772
MLA
Lu, B., Wang, Y., Wei, X., Rong, L., Wei, D., Yan, C., Wang, D., Sun, J."Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma". Molecular Medicine Reports 5.4 (2012): 1033-1036.
Chicago
Lu, B., Wang, Y., Wei, X., Rong, L., Wei, D., Yan, C., Wang, D., Sun, J."Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma". Molecular Medicine Reports 5, no. 4 (2012): 1033-1036. https://doi.org/10.3892/mmr.2012.772
Copy and paste a formatted citation
x
Spandidos Publications style
Lu B, Wang Y, Wei X, Rong L, Wei D, Yan C, Wang D and Sun J: Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Mol Med Rep 5: 1033-1036, 2012.
APA
Lu, B., Wang, Y., Wei, X., Rong, L., Wei, D., Yan, C. ... Sun, J. (2012). Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Molecular Medicine Reports, 5, 1033-1036. https://doi.org/10.3892/mmr.2012.772
MLA
Lu, B., Wang, Y., Wei, X., Rong, L., Wei, D., Yan, C., Wang, D., Sun, J."Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma". Molecular Medicine Reports 5.4 (2012): 1033-1036.
Chicago
Lu, B., Wang, Y., Wei, X., Rong, L., Wei, D., Yan, C., Wang, D., Sun, J."Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma". Molecular Medicine Reports 5, no. 4 (2012): 1033-1036. https://doi.org/10.3892/mmr.2012.772
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