microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review)

Jiang,Yan-Wen; Chen,Liang-An

doi:10.3892/mmr.2012.776

microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review)

Authors:
- Yan-Wen Jiang
- Liang-An Chen
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Affiliations: Department of Respiratory Desease, The General Hospital of the Chinese People's Liberation Army, Beijing 100853, P.R. China, Department of Respiratory Desease, The General Hospital of the Chinese People's Liberation Army, Beijing 100853, P.R. China
Published online on: February 3, 2012 https://doi.org/10.3892/mmr.2012.776
Pages: 890-894

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Abstract

Lung cancer remains the leading cause of cancer-related death worldwide for both men and women, and non-small cell lung cancer (NSCLC) accounts for approximately 80% of all cases. Despite improvements in early diagnosis and newly developed therapies, the 5-year survival rate for NSCLC patients remains low (15%). Therapy in NSCLC has reached a plateau. Understanding genomic medicine may provide insight into the oncogenesis of lung cancer and open the door to molecular diagnosis, new biomarkers and a more accurate prognosis of lung cancer. It is well known that almost half of the genes regulated by microRNAs (miRNAs) are located in cancer-associated genomic regions. In the present study, we discuss the potential of miRNAs to function as suppressors and biomarkers for chemoresistance and prognosis of lung cancer.

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