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April 2012 Volume 5 Issue 4

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Review

microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review)

  • Authors:
    • Yan-Wen Jiang
    • Liang-An Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Desease, The General Hospital of the Chinese People's Liberation Army, Beijing 100853, P.R. China, Department of Respiratory Desease, The General Hospital of the Chinese People's Liberation Army, Beijing 100853, P.R. China
  • Pages: 890-894
    |
    Published online on: February 3, 2012
       https://doi.org/10.3892/mmr.2012.776
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Abstract

Lung cancer remains the leading cause of cancer-related death worldwide for both men and women, and non-small cell lung cancer (NSCLC) accounts for approximately 80% of all cases. Despite improvements in early diagnosis and newly developed therapies, the 5-year survival rate for NSCLC patients remains low (15%). Therapy in NSCLC has reached a plateau. Understanding genomic medicine may provide insight into the oncogenesis of lung cancer and open the door to molecular diagnosis, new biomarkers and a more accurate prognosis of lung cancer. It is well known that almost half of the genes regulated by microRNAs (miRNAs) are located in cancer-associated genomic regions. In the present study, we discuss the potential of miRNAs to function as suppressors and biomarkers for chemoresistance and prognosis of lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y and Chen L: microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review). Mol Med Rep 5: 890-894, 2012.
APA
Jiang, Y., & Chen, L. (2012). microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review). Molecular Medicine Reports, 5, 890-894. https://doi.org/10.3892/mmr.2012.776
MLA
Jiang, Y., Chen, L."microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review)". Molecular Medicine Reports 5.4 (2012): 890-894.
Chicago
Jiang, Y., Chen, L."microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review)". Molecular Medicine Reports 5, no. 4 (2012): 890-894. https://doi.org/10.3892/mmr.2012.776
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y and Chen L: microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review). Mol Med Rep 5: 890-894, 2012.
APA
Jiang, Y., & Chen, L. (2012). microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review). Molecular Medicine Reports, 5, 890-894. https://doi.org/10.3892/mmr.2012.776
MLA
Jiang, Y., Chen, L."microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review)". Molecular Medicine Reports 5.4 (2012): 890-894.
Chicago
Jiang, Y., Chen, L."microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (Review)". Molecular Medicine Reports 5, no. 4 (2012): 890-894. https://doi.org/10.3892/mmr.2012.776
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