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Article

TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons

  • Authors:
    • Jun Zhou
    • Shang-Long Yao
    • Cheng-Xiang Yang
    • Ji-Ying Zhong
    • Han-Bing Wang
    • Yan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, First People's Hospital of Foshan, Foshan, Guangdong, P.R. China, Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China
  • Pages: 1049-1052
    |
    Published online on: February 3, 2012
       https://doi.org/10.3892/mmr.2012.778
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Abstract

The present study was conducted to determine whether the activation of TRESK in the dorsal root ganglion (DRG) by the TRESK gene recombinant adenovirus vector inhibits the capsaicin-evoked substance P (SP) release using a radioimmunoassay. TRESK is an outwardly rectifying K+ current channel that contributes to the resting potential and is the most important background potassium channel in DRG. Previous studies have shown that neuropathic pain (NP) is closely related to the regulation of certain potassium channels in DRG neurons, while DRG-released SP is important in the peripheral mechanism of NP. In the present study, the TRESK gene adenovirus vector significantly enhanced the TRESK mRNA and protein of the cultured rat DRG neurons. Radioimmunoassay analysis revealed that the capsaicin‑mediated SP release was significantly inhibited by the TRESK gene recombinant adenovirus vector in rat DRG neurons. These findings suggest that TRESK plays a role in adjusting the release of SP in DRG, which is related to NP.
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1 

D KangE MariashD KimFunctional expression of TRESK-2, a new member of the tandem-pore K+ channel familyJ Biol Chem2792806328070200410.1074/jbc.M40294020015123670

2 

D KangD KimTREK-2(K2P 10.1) and TRESK(K2P 18.1) are major background K+ channels in dorsal root ganglion neuronsAm J Physiol Cell Physiol2911381462006

3 

C LiuJD AuHL ZouJF CottenCS YostPotent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anestheticsAnesth Analg9917151722200410.1213/01.ANE.0000136849.07384.4415562060

4 

B KeshavaprasadC LiuJD AuCH KindlerJF CottenCS YostSpecies-specific differences in response to anesthetics and other modulators by the K2P channel TRESKAnesth Analg10110421049200510.1213/01.ane.0000168447.87557.5a16192517

5 

M RigoniM TrevisaniD GazzieriNeurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodo-resiniferatoxinBr J Pharmacol138977985200310.1038/sj.bjp.070511012642400

6 

J NemethD ReglodiG PozsgaiEffect of pituitary adenylate cyclase activating polypeptide-38 on sensory neuropeptide release and neurogenic inflammation in rats and miceNeuroscience143223230200610.1016/j.neuroscience.2006.07.02816938409

7 

MS CarterJE KrauseStructure, expression and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K and neuropeptide gammaJ Neurosci10220322141990

8 

A Ribeiro-da-SilvaT HökfeltNeuroanatomical localisation of substance P in the CNS and sensory neuronsNeuropeptides34256271200010.1054/npep.2000.083411049730

9 

J ZhouSL YaoCX YangChanges in expression of TRESK mRNA in dorsal root ganglion in a rat model of neuropathic painChin J Anesthesiol311831852011

10 

J ZhouSL YaoCX YangConstruction of the recombinant adenovirus vector of rat TRESK geneChin J Anesthesiol312962982011

11 

HB TangA InoueK OshitaY NakataSensitization of vanilloid receptor 1 induced by bradykinin via the activation of second messenger signaling cascades in rat primary afferent neuronsEur J Pharmacol4983743200410.1016/j.ejphar.2004.07.07615363973

12 

P HalfonM BourlièreG PénarandaH KhiriD OuzanReal-time PCR assays for hepatitis C virus (HCV) RNA quantitation are adequate for clinical management of patients with chronic HCV infectionJ Clin Microbiol4425072511200610.1128/JCM.00163-0616825372

13 

A InoueT HashimotoI Hide5-Hydroxytrytamine-facilitated release of substance P from rat spinal cord slices is mediated by nitric oxide and cyclic GMPJ Neurochem68128133199710.1046/j.1471-4159.1997.68010128.x8978718

14 

F VianaE de la PeñaC BelmonteSpecificity of cold thermotransduction is determined by differential ionic channel expressionNat Neurosci5254260200210.1038/nn80911836533

15 

A AllouiK ZimmermannJ MametTREK-1, a K+ channel involved in polymodal pain perceptionEMBO J25236823762006

16 

T DoblerA SpringaufS TovornikTRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neuronesJ Physiol5858678792007

17 

TK BaumannKJ BurchielSL IngramME MartensonResponses of adult human dorsal root ganglion neurons in culture to capsaicin and low pHPain653138199610.1016/0304-3959(95)00145-X8826487

18 

TK BaumannP ChaudharyME MartensonBackground potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic painEur J Neurosci1913431351200410.1111/j.1460-9568.2004.03097.x15016092

19 

YR WenMR SuterY KawasakiNerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury modelAnesthesiology107312321200710.1097/01.anes.0000270759.11086.e717667577

20 

W GuoH WangM WatanabeGlial-cytokine-neuronal interactions underlying the mechanisms of persistent painJ Neurosci2760066018200710.1523/JNEUROSCI.0176-07.200717537972

21 

M TominagaM NumazakiT IidaRegulation mechanisms of vanilloid receptorsNovartis Found Symp261412200410.1002/0470869127.ch2

22 

H NakagawaA HiuraCapsaicin, transient receptor potential (TRP) protein subfamilies and the particular relationship between capsaicin receptors and small primary sensory neuronsAnat Sci Int81135155200610.1111/j.1447-073X.2006.00141.x

23 

HS SmithArachidonic acid pathways in nociceptionJ Support Oncol42772872006

24 

YC WooSS ParkAR SubietaTJ BrennanChanges in tissue, Ph and temperature after incision indicate acidosis may contribute to postoperative painAnesthesiology101468475200410.1097/00000542-200408000-0002915277931

25 

G CzirjákP EnyediTargeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESKJ Biol Chem2811467714682200616569637

26 

G CzirjákP EnyediZinc and mercury ions distinguish TRESK from the other two-pore-domain K+ channelsMol Pharmacol6910241032200616354767

27 

G CzirjákZE TóthP EnyediThe two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurinJ Biol Chem27918550185582004

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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Yao S, Yang C, Zhong J, Wang H and Zhang Y: TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Mol Med Rep 5: 1049-1052, 2012.
APA
Zhou, J., Yao, S., Yang, C., Zhong, J., Wang, H., & Zhang, Y. (2012). TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Molecular Medicine Reports, 5, 1049-1052. https://doi.org/10.3892/mmr.2012.778
MLA
Zhou, J., Yao, S., Yang, C., Zhong, J., Wang, H., Zhang, Y."TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons". Molecular Medicine Reports 5.4 (2012): 1049-1052.
Chicago
Zhou, J., Yao, S., Yang, C., Zhong, J., Wang, H., Zhang, Y."TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons". Molecular Medicine Reports 5, no. 4 (2012): 1049-1052. https://doi.org/10.3892/mmr.2012.778
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Yao S, Yang C, Zhong J, Wang H and Zhang Y: TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Mol Med Rep 5: 1049-1052, 2012.
APA
Zhou, J., Yao, S., Yang, C., Zhong, J., Wang, H., & Zhang, Y. (2012). TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Molecular Medicine Reports, 5, 1049-1052. https://doi.org/10.3892/mmr.2012.778
MLA
Zhou, J., Yao, S., Yang, C., Zhong, J., Wang, H., Zhang, Y."TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons". Molecular Medicine Reports 5.4 (2012): 1049-1052.
Chicago
Zhou, J., Yao, S., Yang, C., Zhong, J., Wang, H., Zhang, Y."TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons". Molecular Medicine Reports 5, no. 4 (2012): 1049-1052. https://doi.org/10.3892/mmr.2012.778
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