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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate

  • Authors:
    • Wen-Yan Li
    • Chun-Xia Yao
    • Shu-Feng Zhang
    • Shu-Ling Wang
    • Tian-Qi Wang
    • Cheng-Juan Xiong
    • Yue-Bai Li
    • Ming-Xi Zang

  • View Affiliations / Copyright

    Affiliations: Basic Medical College and Department of Biochemistry and Molecular Biology, Zhengzhou University, Zhengzhou City, Henan 450001, P.R. China
  • Pages: 1396-1400
    |
    Published online on: March 20, 2012
       https://doi.org/10.3892/mmr.2012.841
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Abstract

We recently demonstrated that fenofibrate induces the activities of citrate synthase and NADH oxidase in cardiac mitochondria. To further determine the molecular mechanisms underlying fenofibrate action, 8-week-old mice were administered fenofibrate (100 mg/kg/day) for 7 and 14 days, and the expression of genes involved in cardiac mitochondrial function, such as nuclear respiratory factor 1 transcript variant 2 (NRF-1-L) and 6 (NRF-1-S), mitochondrial outer membrane protein 40 (Tom40), lipoic acid synthetase (Lias), cytochrome b, medium-chain acyl-coenzyme A dehydrogenase (MCAD) and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) was determined. Expression of PGC-1α, a key regulator of the entire fatty acid oxidation system, was significantly downregulated after 14 days of fenofibrate administration. Moreover, ventricular triglycerides were also accumulated following 14 days of fenofibrate administration. Thus, fenofibrate functions to improve myocardial lipid accumulation and to prevent PGC-1α induction, which is crucial for understanding the molecular mechanisms underlying fenofibrate action on the heart.

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Copy and paste a formatted citation
Spandidos Publications style
Li W, Yao C, Zhang S, Wang S, Wang T, Xiong C, Li Y and Zang M: Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate. Mol Med Rep 5: 1396-1400, 2012.
APA
Li, W., Yao, C., Zhang, S., Wang, S., Wang, T., Xiong, C. ... Zang, M. (2012). Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate. Molecular Medicine Reports, 5, 1396-1400. https://doi.org/10.3892/mmr.2012.841
MLA
Li, W., Yao, C., Zhang, S., Wang, S., Wang, T., Xiong, C., Li, Y., Zang, M."Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate". Molecular Medicine Reports 5.6 (2012): 1396-1400.
Chicago
Li, W., Yao, C., Zhang, S., Wang, S., Wang, T., Xiong, C., Li, Y., Zang, M."Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate". Molecular Medicine Reports 5, no. 6 (2012): 1396-1400. https://doi.org/10.3892/mmr.2012.841
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Yao C, Zhang S, Wang S, Wang T, Xiong C, Li Y and Zang M: Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate. Mol Med Rep 5: 1396-1400, 2012.
APA
Li, W., Yao, C., Zhang, S., Wang, S., Wang, T., Xiong, C. ... Zang, M. (2012). Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate. Molecular Medicine Reports, 5, 1396-1400. https://doi.org/10.3892/mmr.2012.841
MLA
Li, W., Yao, C., Zhang, S., Wang, S., Wang, T., Xiong, C., Li, Y., Zang, M."Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate". Molecular Medicine Reports 5.6 (2012): 1396-1400.
Chicago
Li, W., Yao, C., Zhang, S., Wang, S., Wang, T., Xiong, C., Li, Y., Zang, M."Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate". Molecular Medicine Reports 5, no. 6 (2012): 1396-1400. https://doi.org/10.3892/mmr.2012.841
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