Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September 2012 Volume 6 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 2012 Volume 6 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism

  • Authors:
    • Yuan Xie
    • Qianglin Duan
    • Leming Wang
    • Zhu Gong
    • Qiang Wang
    • Haoming Song
    • Hao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, P.R. China
  • Pages: 585-590
    |
    Published online on: June 8, 2012
       https://doi.org/10.3892/mmr.2012.940
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to identify the differences in the expression of cell adhesion molecule-related mRNAs between symptomatic pulmonary embolism (PE) and a control group, and to investigate the interactions among activated leukocytes, platelets and endothelial cells. Whole human gene chip was applied to detect the expression of cell adhesion molecule-related mRNAs in symptomatic PE and in the control group, and statistical analysis was performed. In patients with PE, the expression of the majority of integrin mRNAs located on leukocytes and platelets was significantly upregulated. The expression of mRNAs related to L-selectin and P-selectin glycoprotein ligand was significantly upregulated, while the expression of mRNA related to E-selectin was significantly downregulated. The expression of mRNAs related to classic cadherins and protocadherins was downregulated, and the expression of mRNAs related to vascular endothelial cadherin was significantly downregulated; the expression of mRNAs related to the immunoglobulin superfamily had no obvious difference between the 2 groups. In conclusion, we demonstrated that, in symptomatic PE patients, the adhesion of leukocytes and platelets was enhanced; the activation of endothelial cells was obviously weakened; the adherens junctions among endothelial cells were weakened, with the endothelium becoming more permeable.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Spencer FA, Gore JM, Lessard D, Douketis JD, Emery C and Goldberg RJ: Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study. Arch Intern Med. 168:425–430. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Virchow RLK: Thrombosis and emboli. Science History Publications; Massachusetts, MA: 1998

3 

Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW and Ray JG: Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 126(Suppl 3): 338S–400S. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR and Colwell CW; American College of Chest Physicians. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 133(Suppl 6): 381S–453S. 2008. View Article : Google Scholar

5 

Shackford SR, Rogers FB, Terrien CM, Bouchard P, Ratliff J and Zubis R: A 10-year analysis of venous thromboembolism on the surgical service: the effect of practice guidelines for prophylaxis. Surgery. 144:3–11. 2008.PubMed/NCBI

6 

Smeeth L, Cook C, Thomas S, Hall AJ, Hubbard R and Vallance P: Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting. Lancet. 367:1075–1079. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Xiang-Hua Y, Le-Min W, Ai-Bin L, Zhu G, Riquan L, Xu-You Z, Wei-Wei R and Ye-Nan W: Severe acute respiratory syndrome and venous thromboembolism in multiple organs. Am J Respir Crit Care Med. 182:436–437. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Wang L, Gong Z, Liang A, Xie Y, Liu SL, Yu Z, Wang L and Wang Y: Compromised T-cell immunity and virus-like structure in a patient with pulmonary hypertension. Am J Respir Crit Care Med. 182:434–435. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Haoming S, Lemin W, Zhu G, Aibin L, Yuan X, Wei L, Jinfa J, Wenjun X and Yuqin S: T cell-mediated immune deficiency or compromise in patients with CTEPH. Am J Respir Crit Care Med. 183:417–418. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Wang L, Gong Z, Jiang J, Xu W, Duan Q, Liu J and Qin C: Confusion of wide thrombolytic time window for acute pulmonary embolism: mass spectrographic analysis for thrombus proteins. Am J Respir Crit Care Med. 184:145–146. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Prescott SM, Weyrich AS and Zimmerman GA: Classification of venous thromboembolism (VTE). The clot is hot: inflammation, myeloid leukocytes, and venous thromboembolism. J Thromb Haemost. 3:2571–2573. 2005.PubMed/NCBI

12 

Henke PK and Wakefield T: Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes. Thromb Res. 123(Suppl 4): S72–S78. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Takada Y, Ye X and Simon S: The integrins. Genome Biol. 8:2152007. View Article : Google Scholar : PubMed/NCBI

14 

Caimi G, Tozzi Ciancarelli MG, Ferrara F, Montana M, Calandrino V, Canino B and Lo Presti R: Deep venous thrombosis: behaviour of the polymorphonuclear leukocyte integrin pattern at baseline and after in vitro activation. Clin Hemorheol Microcirc. 33:11–17. 2005.PubMed/NCBI

15 

Caimi G, Canino B, Ferrara F, Montana M and Lo Presti R: Polymorphonuclear leukocyte integrins in deep venous thrombosis. Clin Appl Thromb Hemost. 11:95–97. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Quinn MJ, Byzova TV, Qin J, Topol EJ and Plow EF: Integrin alphaIIbbeta3 and its antagonism. Arterioscler Thromb Vasc Biol. 23:945–952. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Faralli JA, Schwinn MK, Gonzalez JM Jr, Filla MS and Peters DM: Functional properties of fibronectin in the trabecular meshwork. Exp Eye Res. 88:689–693. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Wagner DD: The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin. Thromb Haemost. 70:105–110. 1993.PubMed/NCBI

19 

Bevilacqua MP, Stengelin S, Gimbrone MA Jr and Seed B: Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 243:1160–1165. 1989. View Article : Google Scholar

20 

Kansas GS: Selectins and their ligands: Current concepts and controversies. Blood. 88:3259–3287. 1996.PubMed/NCBI

21 

Wakefield TW, Myers DD and Henke PK: Mechanisms of venous thrombosis and resolution. Arterioscler Thromb Vasc Biol. 28:387–391. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Gong N and Chatterjee S: Platelet endothelial cell adhesion molecule in cell signaling and thrombosis. Mol Cell Biochem. 253:151–158. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Muller WA: Mechanisms of transendothelial migration of leukocytes. Circ Res. 105:223–230. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Nottebaum AF, Cagna G, Winderlich M, Gamp AC, Linnepe R, Polaschegg C, Filippova K, Lyck R, Engelhardt B, Kamenyeva O, et al: VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med. 205:2929–2945. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM and Shapiro L: C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science. 296:1308–1313. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Hermant B, Bibert S, Concord E, Dublet B, Weidenhaupt M, Vernet T and Gulino-Debrac D: Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration. J Biol Chem. 278:14002–14012. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Dejana E, Orsenigo F and Lampugnani MG: The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci. 121:2115–2122. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Shima Y, Kengaku M, Hirano T, Takeichi M and Uemura T: Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev Cell. 7:205–216. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie Y, Duan Q, Wang L, Gong Z, Wang Q, Song H and Wang H: Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism. Mol Med Rep 6: 585-590, 2012.
APA
Xie, Y., Duan, Q., Wang, L., Gong, Z., Wang, Q., Song, H., & Wang, H. (2012). Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism. Molecular Medicine Reports, 6, 585-590. https://doi.org/10.3892/mmr.2012.940
MLA
Xie, Y., Duan, Q., Wang, L., Gong, Z., Wang, Q., Song, H., Wang, H."Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism". Molecular Medicine Reports 6.3 (2012): 585-590.
Chicago
Xie, Y., Duan, Q., Wang, L., Gong, Z., Wang, Q., Song, H., Wang, H."Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism". Molecular Medicine Reports 6, no. 3 (2012): 585-590. https://doi.org/10.3892/mmr.2012.940
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Duan Q, Wang L, Gong Z, Wang Q, Song H and Wang H: Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism. Mol Med Rep 6: 585-590, 2012.
APA
Xie, Y., Duan, Q., Wang, L., Gong, Z., Wang, Q., Song, H., & Wang, H. (2012). Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism. Molecular Medicine Reports, 6, 585-590. https://doi.org/10.3892/mmr.2012.940
MLA
Xie, Y., Duan, Q., Wang, L., Gong, Z., Wang, Q., Song, H., Wang, H."Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism". Molecular Medicine Reports 6.3 (2012): 585-590.
Chicago
Xie, Y., Duan, Q., Wang, L., Gong, Z., Wang, Q., Song, H., Wang, H."Genomic characteristics of adhesion molecules in patients with symptomatic pulmonary embolism". Molecular Medicine Reports 6, no. 3 (2012): 585-590. https://doi.org/10.3892/mmr.2012.940
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team