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Molecular Medicine Reports
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September 2012 Volume 6 Issue 3

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Article

Inhibitory effect of BMP-2 on the proliferation of breast cancer cells

  • Authors:
    • Anan Chen
    • Dingding Wang
    • Xueting Liu
    • Shuilian He
    • Zhihong Yu
    • Ju Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P.R. China , Department of Biotechnology, Institute of Life Science and Biological Pharmacy, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong 510006, P.R. China
  • Pages: 615-620
    |
    Published online on: June 21, 2012
       https://doi.org/10.3892/mmr.2012.962
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Abstract

Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231 and MCF-7 breast cancer cells. The flow cytometric analysis demonstrated that BMP-2 caused G1 arrest and promoted apoptosis. An increase in p21 and cleaved caspase-3 in the two cell lines was detected by western blot analysis, which may be responsible for the suppression of cancer cell proliferation caused by BMP-2. BMP-2 protected MDA-MB-231 and MCF-7 cells from generating xenograft tumors in nude mice. Thus, BMP-2 may be considered as an inhibitor of breast cancer at the early stages of disease.
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Copy and paste a formatted citation
Spandidos Publications style
Chen A, Wang D, Liu X, He S, Yu Z and Wang : Inhibitory effect of BMP-2 on the proliferation of breast cancer cells. Mol Med Rep 6: 615-620, 2012.
APA
Chen, A., Wang, D., Liu, X., He, S., Yu, Z., & Wang, . (2012). Inhibitory effect of BMP-2 on the proliferation of breast cancer cells. Molecular Medicine Reports, 6, 615-620. https://doi.org/10.3892/mmr.2012.962
MLA
Chen, A., Wang, D., Liu, X., He, S., Yu, Z., Wang, ."Inhibitory effect of BMP-2 on the proliferation of breast cancer cells". Molecular Medicine Reports 6.3 (2012): 615-620.
Chicago
Chen, A., Wang, D., Liu, X., He, S., Yu, Z., Wang, ."Inhibitory effect of BMP-2 on the proliferation of breast cancer cells". Molecular Medicine Reports 6, no. 3 (2012): 615-620. https://doi.org/10.3892/mmr.2012.962
Copy and paste a formatted citation
x
Spandidos Publications style
Chen A, Wang D, Liu X, He S, Yu Z and Wang : Inhibitory effect of BMP-2 on the proliferation of breast cancer cells. Mol Med Rep 6: 615-620, 2012.
APA
Chen, A., Wang, D., Liu, X., He, S., Yu, Z., & Wang, . (2012). Inhibitory effect of BMP-2 on the proliferation of breast cancer cells. Molecular Medicine Reports, 6, 615-620. https://doi.org/10.3892/mmr.2012.962
MLA
Chen, A., Wang, D., Liu, X., He, S., Yu, Z., Wang, ."Inhibitory effect of BMP-2 on the proliferation of breast cancer cells". Molecular Medicine Reports 6.3 (2012): 615-620.
Chicago
Chen, A., Wang, D., Liu, X., He, S., Yu, Z., Wang, ."Inhibitory effect of BMP-2 on the proliferation of breast cancer cells". Molecular Medicine Reports 6, no. 3 (2012): 615-620. https://doi.org/10.3892/mmr.2012.962
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