Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October 2012 Volume 6 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2012 Volume 6 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase

  • Authors:
    • Eun-Sun Choi
    • Sung-Dae Cho
    • Ji-Ae Shin
    • Ki Han Kwon
    • Nam-Pyo Cho
    • Jung-Hyun Shim
  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University, Jeonju 561-756, Republic of Korea , Department of Food Science and Nutrition, College of Health, Welfare and Education, Gwangju University, Gwangju 503-703, Republic of Korea, Department of Biochemistry, College of Medicine, Soonchunhyang University, Cheonan 331-090, Republic of Korea
  • Pages: 843-847
    |
    Published online on: July 4, 2012
       https://doi.org/10.3892/mmr.2012.977
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

For thousands of years in Asia, Althaea rosea Cavanil (ARC) and Plantago major L. (PML) have been used as powerful non-toxic therapeutic agents that inhibit inflammation. However, the anticancer mechanisms and molecular targets of ARC and PML are poorly understood, particularly in epidermal growth factor (EGF)-induced neoplastic cell transformation. The aim of this study was to evaluate the chemopreventive effects and mechanisms of the methanol extracts from ARC (MARC) and PML (MPML) in EGF-induced neoplastic cell transformation of JB6 P+ mouse epidermal cells using an MTS assay, anchorage-independent cell transformation assay and western blotting. Our results showed that MARC and MPML significantly suppressed neoplastic cell transformation by inhibiting the kinase activity of the EGF receptor (EGFR). The activation of EGFR by EGF was suppressed by MARC and MPML treatment in EGFR+/+ cells, but not in EGFR-/- cells. In addition, MARC and MPML inhibited EGF-induced cell proliferation in EGFR-expressing murine embryonic fibroblasts (EGFR+/+). These results strongly indicate that EGFR targeting by MARC and MPML may be a good strategy for chemopreventive or chemotherapeutic applications.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Wang H, Zhou M, Shi B, et al: Identification of an exon 4-deletion variant of epidermal growth factor receptor with increased metastasis-promoting capacity. Neoplasia. 13:461–471. 2011.PubMed/NCBI

2 

Xue C, Wyckoff J, Liang F, et al: Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res. 66:192–197. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Pandiella A, Lehvaslaiho H, Magni M, Alitalo K and Meldolesi J: Activation of an EGFR/neu chimeric receptor: early intracellular signals and cell proliferation responses. Oncogene. 4:1299–1305. 1989.PubMed/NCBI

4 

Liang K, Ang KK, Milas L, Hunter N and Fan Z: The epidermal growth factor receptor mediates radioresistance. Int J Radiat Oncol Biol Phys. 57:246–254. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Ho R, Minturn JE, Hishiki T, et al: Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor. Cancer Res. 65:9868–9875. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Modjtahedi H and Essapen S: Epidermal growth factor receptor inhibitors in cancer treatment: advances, challenges and opportunities. Anticancer Drugs. 20:851–855. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Engelman JA and Cantley LC: A sweet new role for EGFR in cancer. Cancer Cell. 13:375–376. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Chaffanet M, Chauvin C, Laine M, et al: EGF receptor amplification and expression in human brain tumours. Eur J Cancer. 28:11–17. 1992. View Article : Google Scholar

9 

Nishikawa R, Ji XD, Harmon RC, et al: A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA. 91:7727–7731. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Tang P, Steck PA and Yung WK: The autocrine loop of TGF-alpha/EGFR and brain tumors. J Neurooncol. 35:303–314. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Hwang MK, Bode AM, Byun S, et al: Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. Cancer Res. 70:6859–6869. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Newman DJ, Cragg GM and Snader KM: Natural products as sources of new drugs over the period 1981–2002. J Nat Prod. 66:1022–1037. 2003.PubMed/NCBI

13 

Graham JG, Quinn ML, Fabricant DS and Farnsworth NR: Plants used against cancer - an extension of the work of Jonathan Hartwell. J Ethnopharmacol. 73:347–377. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Samuelsen AB: The traditional uses, chemical constituents and biological activities of Plantago major L. A review. J Ethnopharmacol. 71:1–21. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Galvez M, Martin-Cordero C, Lopez-Lazaro M, Cortes F and Ayuso MJ: Cytotoxic effect of Plantago spp. on cancer cell lines. J Ethnopharmacol. 88:125–130. 2003.

16 

Papiez MA: The influence of hollyhock extract administration on testicular function in rats. J Mol Histol. 35:733–740. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Kang NJ, Lee KW, Rogozin EA, et al: Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway. J Biol Chem. 282:32856–32866. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Ehmann LM, Heinemann V and Wollenberg A: New tyrosine kinase and EGFR inhibitors in cancer therapy: Cardiac and skin toxicity as relevant side effects. Part B: skin. Internist (Berl). 52:1359–1364. 2011.(In German).

19 

Cheung CW, Gibbons N, Johnson DW and Nicol DL: Silibinin - a promising new treatment for cancer. Anticancer Agents Med Chem. 10:186–195. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Fahey JW, Haristoy X, Dolan PM, et al: Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA. 99:7610–7615. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Yanaka A, Fahey JW, Fukumoto A, et al: Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev Res (Phila). 2:353–360. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Butler MS: The role of natural product chemistry in drug discovery. J Nat Prod. 67:2141–2153. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Koehn FE and Carter GT: The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 4:206–220. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Shokrzadeh M, Azadbakht M, Ahangar N, Hashemi A and Saeedi Saravi SS: Cytotoxicity of hydro-alcoholic extracts of Cucurbitapepo and Solanum nigrum on HepG2 and CT26 cancer cell lines. Pharmacogn Mag. 6:176–179. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Etkin NL: A Hausa herbal pharmacopoeia: biomedical evaluation of commonly used plant medicines. J Ethnopharmacol. 4:75–98. 1981. View Article : Google Scholar : PubMed/NCBI

26 

Misumi N, Hiraike M, Nawata F, et al: [Protective effects of d-chlorpheniramine maleate pre-treatment against acute side effects of Irinotecan(CPT- 11)]. Gan To Kagaku Ryoho. 38:1149–1153. 2011.(In Japanese).

27 

Sun X, Zhang J, Gupta R, Macgibbon AK, Kuhn-Sherlock B and Krissansen GW: Dairy milk fat augments paclitaxel therapy to suppress tumour metastasis in mice, and protects against the side-effects of chemotherapy. Clin Exp Metastasis. 28:675–688. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Wang DF, Shang JY and Yu QH: Analgesic and anti-inflammatory effects of the flower of Althaea rosea (L.) Cav. Zhongguo Zhong Yao Za Zhi. 14(46–48): 641989.(In Chinese).

29 

Furuse J: Growth factors as therapeutic targets in HCC. Crit Rev Oncol Hematol. 67:8–15. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Khalil MY, Grandis JR and Shin DM: Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer. Expert Rev Anticancer Ther. 3:367–380. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Mimeault M, Pommery N and Henichart JP: New advances on prostate carcinogenesis and therapies: involvement of EGF-EGFR transduction system. Growth Factors. 21:1–14. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Amstad PA, Liu H, Ichimiya M, Berezesky IK and Trump BF: Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells. Carcinogenesis. 18:479–484. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Kang NJ, Lee KW, Kwon JY, et al: Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling. Cancer Prev Res (Phila). 1:522–531. 2008. View Article : Google Scholar

34 

Dong Z and Bode AM: Proceedings - targeting carcinogenesis: transduction, transcription, translation. Mol Carcinog. 45:353–354. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Nguyen-Ba G and Vasseur P: Epigenetic events during the process of cell transformation induced by carcinogens (Review). Oncol Rep. 6:925–932. 1999.PubMed/NCBI

36 

Lee KW, Kang NJ, Rogozin EA, et al: Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis. 28:1918–1927. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Ciardiello F and Tortora G: EGFR antagonists in cancer treatment. N Engl J Med. 358:1160–1174. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Gschwind A, Zwick E, Prenzel N, Leserer M and Ullrich A: Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene. 20:1594–1600. 2001. View Article : Google Scholar

39 

Fichera A, Little N, Jagadeeswaran S, et al: Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res. 67:827–835. 2007. View Article : Google Scholar

40 

Wakeling AE, Guy SP, Woodburn JR, et al: ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 62:5749–5754. 2002.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Choi E, Cho S, Shin J, Kwon KH, Cho N and Shim J: Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase. Mol Med Rep 6: 843-847, 2012.
APA
Choi, E., Cho, S., Shin, J., Kwon, K.H., Cho, N., & Shim, J. (2012). Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase. Molecular Medicine Reports, 6, 843-847. https://doi.org/10.3892/mmr.2012.977
MLA
Choi, E., Cho, S., Shin, J., Kwon, K. H., Cho, N., Shim, J."Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase". Molecular Medicine Reports 6.4 (2012): 843-847.
Chicago
Choi, E., Cho, S., Shin, J., Kwon, K. H., Cho, N., Shim, J."Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase". Molecular Medicine Reports 6, no. 4 (2012): 843-847. https://doi.org/10.3892/mmr.2012.977
Copy and paste a formatted citation
x
Spandidos Publications style
Choi E, Cho S, Shin J, Kwon KH, Cho N and Shim J: Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase. Mol Med Rep 6: 843-847, 2012.
APA
Choi, E., Cho, S., Shin, J., Kwon, K.H., Cho, N., & Shim, J. (2012). Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase. Molecular Medicine Reports, 6, 843-847. https://doi.org/10.3892/mmr.2012.977
MLA
Choi, E., Cho, S., Shin, J., Kwon, K. H., Cho, N., Shim, J."Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase". Molecular Medicine Reports 6.4 (2012): 843-847.
Chicago
Choi, E., Cho, S., Shin, J., Kwon, K. H., Cho, N., Shim, J."Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase". Molecular Medicine Reports 6, no. 4 (2012): 843-847. https://doi.org/10.3892/mmr.2012.977
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team