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Review

Role of microRNAs in peripheral artery disease (Review)

  • Authors:
    • Xiangyu Zhou
    • Ping Yuan
    • Yanzheng He
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichun 646000, P.R. China, Department of Cerebral Vascular Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichun 646000, P.R. China
  • Pages: 695-700
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    Published online on: July 5, 2012
       https://doi.org/10.3892/mmr.2012.978
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Abstract

Peripheral arterial disease (PAD) involves a general vascular problem of diffuse atherosclerosis. The key pathological process is characterized by the aberrant proliferation of vascular smooth muscle cells and the formation of neointimal lesions. The molecular mechanisms involved in the regulation of the occurrence and development of PAD remain unclear. microRNAs (miRNAs) are highly conserved 20-25 nt-long non-coding RNAs that negatively regulate gene expression. Recent evidence has demonstrated that specific miRNAs are involved in the pathological processes of PAD, and these miRNAs are found to be critical modulators of vascular cell functions, including cell differentiation, contraction, migration, proliferation and apoptosis. This review summarizes findings of studies regarding the roles of specific miRNAs in PAD.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Yuan P and He Y: Role of microRNAs in peripheral artery disease (Review). Mol Med Rep 6: 695-700, 2012.
APA
Zhou, X., Yuan, P., & He, Y. (2012). Role of microRNAs in peripheral artery disease (Review). Molecular Medicine Reports, 6, 695-700. https://doi.org/10.3892/mmr.2012.978
MLA
Zhou, X., Yuan, P., He, Y."Role of microRNAs in peripheral artery disease (Review)". Molecular Medicine Reports 6.4 (2012): 695-700.
Chicago
Zhou, X., Yuan, P., He, Y."Role of microRNAs in peripheral artery disease (Review)". Molecular Medicine Reports 6, no. 4 (2012): 695-700. https://doi.org/10.3892/mmr.2012.978
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Yuan P and He Y: Role of microRNAs in peripheral artery disease (Review). Mol Med Rep 6: 695-700, 2012.
APA
Zhou, X., Yuan, P., & He, Y. (2012). Role of microRNAs in peripheral artery disease (Review). Molecular Medicine Reports, 6, 695-700. https://doi.org/10.3892/mmr.2012.978
MLA
Zhou, X., Yuan, P., He, Y."Role of microRNAs in peripheral artery disease (Review)". Molecular Medicine Reports 6.4 (2012): 695-700.
Chicago
Zhou, X., Yuan, P., He, Y."Role of microRNAs in peripheral artery disease (Review)". Molecular Medicine Reports 6, no. 4 (2012): 695-700. https://doi.org/10.3892/mmr.2012.978
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