Pathological features and prognosis of different molecular subtypes of breast cancer

Wang,Guo-Sheng; Zhu,Hong; Bi,Shi-Jie

doi:10.3892/mmr.2012.981

October 2012 Volume 6 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October 2012 Volume 6 Issue 4

Full Size Image

Article

Pathological features and prognosis of different molecular subtypes of breast cancer

Authors:
- Guo-Sheng Wang
- Hong Zhu
- Shi-Jie Bi
View Affiliations / Copyright

Affiliations: Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
Pages: 779-782
|
Published online on: July 9, 2012

https://doi.org/10.3892/mmr.2012.981
Expand metrics +

Abstract

To examine the pathological features and prognosis of different molecular subtypes of breast cancer, the clinical data of 892 breast cancer patients were retrospectively analyzed and divided into four subtypes according to hormone receptor expression in breast cancer tissue: Her-2 overexpression, luminal A, luminal B and basal-like subtypes. The pathological data and prognosis of these subtypes were compared. Of the 892 breast cancer patients, there were 46 cases (5.2%) with Her-2 overexpression-type, 698 cases (78.3%) with luminal A-type, 38 cases (4.3%) with luminal B‑type and 110 patients (12.2%) with basal-like-type. Immunohistochemistry was used to identify the progesterone and estrogen receptors in the tumor tissues. The χ2 test was used to verify the measurement data. The Cox proportional hazard regression model was used for the univariate and multivariate analyses. Results showed there was no statistical difference for lymphatic metastasis among the various molecular subtypes of breast cancer (P>0.05). The distant metastatic rate of patients with Her-2-type breast cancer was significantly higher compared to patients with the other three subtypes (P<0.05). The difference in local recurrence among molecular subtypes was not significantly significant (P>0.05). Lymph node metastasis, age and different molecular subtypes were found to have an impact on patient overall survival (OS) and disease-free survival (DFS). Her-2 overexpression-type breast cancer patients had the lowest 9-year DFS and 7-year OS compared to the other subtypes (P<0.05). Thus, Her-2-type was associated with the worst prognosis. In conlusion, the molecular typing of breast cancer has important clinical value in prognosis estimation and is expected to affect breast cancer treatment approaches.

View Figures

View References

1	Perou CM, Sødie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI
2	Holm K, Hegardt C, Staaf J, Vallon-Christersson J, Jönsson G, Olsson H, Borg A and Ringnér M: Molecular subtypes of breast cancer are associated with characteristic DNA methylation pattern. Breast Cancer Res. 12:R362010. View Article : Google Scholar : PubMed/NCBI
3	Maambo EC and Ioffe OB: Molecular classification and prognostication of breast cancer. Pathol Case Rev. 14:129–134. 2009. View Article : Google Scholar
4	Kao KJ, Chang KM, Hsu HC and Huang AT: Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. BMC Cancer. 11:1432011. View Article : Google Scholar : PubMed/NCBI
5	Carey LA, Pemu CM, Livasy CA, et al: Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 295:2492–2502. 2006. View Article : Google Scholar : PubMed/NCBI
6	Ihemelandu CU, Leffall LD Jr, Dewitty RL, et al: Molecular breast cancer subtypes in premenopausal and postmenopausal African-American women, age-specific prevalence and survival. J Stag Res. 143:109–118. 2007. View Article : Google Scholar : PubMed/NCBI
7	Strehl JD, Wachter DL, Fasching PA, Beckmann MW and Hartmann A: Invasive breast cancer: recognition of molecular subtypes. Breast Care (Basel). 6:258–264. 2011.PubMed/NCBI
8	Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, He X and Perou CM: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res. 12:R682010. View Article : Google Scholar : PubMed/NCBI
9	Chandran U, Hirshfield KM and Bandera EV: The role of anthropometric and nutritional factors on breast cancer risk in African-American women. Public Health Nutr. 29:1–11. 2011.PubMed/NCBI
10	Parker JS, Mullins M, Cheang MC, et al: Supervised risk predictor of breast cancer on intrinsic subtypes. J Clin Oncol. 27:1160–1167. 2009. View Article : Google Scholar : PubMed/NCBI
11	Voduc KD, Cheang MC, Tyldesley S, Gelmon K, Nielsen TO and Kennecke H: Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol. 28:1684–1691. 2010. View Article : Google Scholar : PubMed/NCBI
12	Lund MJ, Trivers KF, Porter PL, et al: Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA. Breast Cancer Res Treat. 113:357–370. 2009. View Article : Google Scholar : PubMed/NCBI
13	Brinton LA, Sherman ME, Carreon JD and Anderson WF: Recent trends in breast cancer among younger women in the United States. J Natl Cancer Inst. 100:1643–1648. 2008. View Article : Google Scholar : PubMed/NCBI
14	Carey LA, Dees EC, Sawyer L, et al: The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res. 13:2329–2334. 2007. View Article : Google Scholar : PubMed/NCBI
15	Reis-Filho JS and Pusztai L: Gene expression profiling in breast cancer: classification, prognostication, and prediction. Lancet. 378:1812–1823. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pathological features and prognosis of different molecular subtypes of breast cancer

This article is mentioned in:

Abstract

Related Articles