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Article

The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population

  • Authors:
    • Jing Guo
    • Yong-Hui He
    • Feng Chen
    • Min-Hui Jiang
    • Shu-Ping Gao
    • Ya‑Ming  Su
    • Gui-Liang Shi
    • Xin-Tao Deng
    • Jian-Hua Zhu
    • Min Pan
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Fourth People's Hospital of Wuxi and Affiliated Hospital of Jiangnan University, Wuxi 216042, P.R. China, Department of Intensive Care Unit, Xinghua People's Hospital, Xinghua 225700, P.R. China, Department of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, P.R. China, Department of Cardiology, Ningxia People's Hospital, Yinchuan 750021, P.R. China, Institute of Cardiovascular Research, Nantong University, Nantong 226001, P.R. China, Department of Cardiology, Xinghua People's Hospital, Xinghua 225700, P.R. China
  • Pages: 894-896
    |
    Published online on: July 18, 2012
       https://doi.org/10.3892/mmr.2012.995
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Abstract

Interleukin-10 (IL-10) is a multifunctional anti‑inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL‑10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild‑type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.
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Copy and paste a formatted citation
Spandidos Publications style
Guo J, He Y, Chen F, Jiang M, Gao S, Su YM, Shi G, Deng X, Zhu J, Pan M, Pan M, et al: The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population. Mol Med Rep 6: 894-896, 2012.
APA
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y. ... Pan, M. (2012). The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population. Molecular Medicine Reports, 6, 894-896. https://doi.org/10.3892/mmr.2012.995
MLA
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y., Shi, G., Deng, X., Zhu, J., Pan, M."The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population". Molecular Medicine Reports 6.4 (2012): 894-896.
Chicago
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y., Shi, G., Deng, X., Zhu, J., Pan, M."The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population". Molecular Medicine Reports 6, no. 4 (2012): 894-896. https://doi.org/10.3892/mmr.2012.995
Copy and paste a formatted citation
x
Spandidos Publications style
Guo J, He Y, Chen F, Jiang M, Gao S, Su YM, Shi G, Deng X, Zhu J, Pan M, Pan M, et al: The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population. Mol Med Rep 6: 894-896, 2012.
APA
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y. ... Pan, M. (2012). The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population. Molecular Medicine Reports, 6, 894-896. https://doi.org/10.3892/mmr.2012.995
MLA
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y., Shi, G., Deng, X., Zhu, J., Pan, M."The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population". Molecular Medicine Reports 6.4 (2012): 894-896.
Chicago
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y., Shi, G., Deng, X., Zhu, J., Pan, M."The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population". Molecular Medicine Reports 6, no. 4 (2012): 894-896. https://doi.org/10.3892/mmr.2012.995
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