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Article

Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study

  • Authors:
    • Aga Syed Sameer
    • Fazl Q. Parray
    • Manzoor Ahmad Dar
    • Saniya Nissar
    • Mujeeb Zafar Banday
    • Sabha Rasool
    • G. M. Gulzar
    • Nissar A. Chowdri
    • Mushtaq A. Siddiqi
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Molecular Medicine, Sher‑I‑Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India, Department of General Surgery, Sher‑I‑Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India, Department of Biotechnology, University of Kashmir, Hazratbal, Srinagar, Kashmir, India, Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, Kashmir, India, Department of Gastroenterology, Sher‑I‑Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
  • Pages: 811-815
    |
    Published online on: January 24, 2013
       https://doi.org/10.3892/mmr.2013.1287
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Abstract

The present study aimed to analyse the role of cyclin D1 A870G polymorphism in modulating the susceptibility to colorectal cancer (CRC) in the Kashmiri population. The genotype distribution of the cyclin D1 gene in 130 CRC cases in comparison with 160 healthy controls was investigated. No direct significant association between cyclin D1 genotypes and CRC was observed; however, the AG and AA genotypes were found to be associated with an increased risk of CRC compared to the GG genotype, with an almost 2-fold increase in OR. This study suggests that the cyclin D1 polymorphism is associated with an increased risk of CRC in the Kashmiri population.
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Copy and paste a formatted citation
Spandidos Publications style
Sameer AS, Parray FQ, Dar MA, Nissar S, Banday MZ, Rasool S, Gulzar GM, Chowdri NA and Siddiqi MA: Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study. Mol Med Rep 7: 811-815, 2013.
APA
Sameer, A.S., Parray, F.Q., Dar, M.A., Nissar, S., Banday, M.Z., Rasool, S. ... Siddiqi, M.A. (2013). Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study. Molecular Medicine Reports, 7, 811-815. https://doi.org/10.3892/mmr.2013.1287
MLA
Sameer, A. S., Parray, F. Q., Dar, M. A., Nissar, S., Banday, M. Z., Rasool, S., Gulzar, G. M., Chowdri, N. A., Siddiqi, M. A."Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study". Molecular Medicine Reports 7.3 (2013): 811-815.
Chicago
Sameer, A. S., Parray, F. Q., Dar, M. A., Nissar, S., Banday, M. Z., Rasool, S., Gulzar, G. M., Chowdri, N. A., Siddiqi, M. A."Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study". Molecular Medicine Reports 7, no. 3 (2013): 811-815. https://doi.org/10.3892/mmr.2013.1287
Copy and paste a formatted citation
x
Spandidos Publications style
Sameer AS, Parray FQ, Dar MA, Nissar S, Banday MZ, Rasool S, Gulzar GM, Chowdri NA and Siddiqi MA: Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study. Mol Med Rep 7: 811-815, 2013.
APA
Sameer, A.S., Parray, F.Q., Dar, M.A., Nissar, S., Banday, M.Z., Rasool, S. ... Siddiqi, M.A. (2013). Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study. Molecular Medicine Reports, 7, 811-815. https://doi.org/10.3892/mmr.2013.1287
MLA
Sameer, A. S., Parray, F. Q., Dar, M. A., Nissar, S., Banday, M. Z., Rasool, S., Gulzar, G. M., Chowdri, N. A., Siddiqi, M. A."Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study". Molecular Medicine Reports 7.3 (2013): 811-815.
Chicago
Sameer, A. S., Parray, F. Q., Dar, M. A., Nissar, S., Banday, M. Z., Rasool, S., Gulzar, G. M., Chowdri, N. A., Siddiqi, M. A."Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study". Molecular Medicine Reports 7, no. 3 (2013): 811-815. https://doi.org/10.3892/mmr.2013.1287
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