Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March 2013 Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 2013 Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model

  • Authors:
    • Yan Lei
    • Zhihua Zheng
    • Ying Wang
    • Yuyun Liu
    • Rongjun Liu
    • Qingdong Xu
    • Xueqing Yu
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First Affiliated Hospital, Sun Yat‑Sen University and Key Laboratory of Nephrology, Ministry of Health, Guangzhou 510080, P.R. China
  • Pages: 831-835
    |
    Published online on: January 28, 2013
       https://doi.org/10.3892/mmr.2013.1293
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study was undertaken to confirm whether sulodexide aleviates neointimal hyperplasia by regulating angiopoietin/Tie in a rat femoral arteriovenous fistula (AVF) model. Sprague Dawley rats were divided into four groups: sham, model, treatment and treatment control. An arteriovenous shunt model was created in the model and treatment groups. Sulodexide was subcutaneously administered (10 mg/kg/day) 6 times per week for 8 weeks in the treatment and treatment control groups. Histology and immunofluorescence were analyzed and the protein expression of angiopoietin‑1, angiopoietin‑2, Tie‑2, p‑ERK and total‑ERK were tested by ELISA and/or western blotting after 8 weeks. HE staining revealed that sulodexide was able to partially alleviate intimal hyperplasia of remodeled veins in the AVF model. Additionally, sulodexide was able to decrease angiopoietin‑2 and Tie‑2 expression while increasing angiopoietin‑1 expression in AVF tissue. Sulodexide was also able to decrease ERK phosphorylation which was increased in the model. Serum levels of soluble Tie-2 (sTie‑2) were also significantly decreased by sulodexide compared with the model. Immunofluorescent analysis also confirmed that sulodexide was able to decrease angiopoietin‑2 expression, possibly partially by inhibiting endothelial cell proliferation. Sulodexide may alleviate venous intimal hyperplasia by regulating the angiopoietin/Tie system, which may play a significant role in assisting remodeled veins to cope with their new biomechanical environment, but whether the angiopoietin/Tie system is beneficial or not requires further study.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Manca O, Pisano GL, Carta P, et al: The management of hemodialysis arteriovenous fistulas in well functioning renal transplanted patients: many doubts, few certainties. J Vasc Access. 6:182–186. 2005.PubMed/NCBI

2 

Lee T and Roy-Chaudhury P: Advances and new frontiers in the pathophysiology of venous neointimal hyperplasia and dialysis access stenosis. Adv Chronic Kidney Dis. 16:329–338. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Langer S, Heiss C, Paulus N, et al: Functional and structural response of arterialized femoral veins in a rodent AV fistula model. Nephrol Dial Transplant. 24:2201–2206. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Kokubo T, Ishikawa N, Uchida H, et al: CKD accelerates development of neointimal hyperplasia in arteriovenous fistulas. J Am Soc Nephrol. 20:1236–1245. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Langer S, Kokozidou M, Heiss C, et al: Chronic kidney disease aggravates arteriovenous fistula damage in rats. Kidney Int. 78:1312–1321. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Rodríguez-Pla A, Bosch-Gil JA, Rosselló-Urgell J, Huguet-Redecilla P, Stone JH and Vilardell-Tarres M: Metalloproteinase-2 and -9 in giant cell arteritis: involvement in vascular remodeling. Circulation. 112:264–269. 2005.PubMed/NCBI

7 

Caplice NM, Wang S, Tracz M, et al: Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat. Am J Physiol Renal Physiol. 293:F470–F475. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Kanwar YS: Functional duality of progenitor cells influxing into arteriovenous fistula during its neoangiogenesis. Am J Physiol Renal Physiol. 293:F468–F469. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Maisonpierre PC, Suri C, Jones PF, et al: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science. 277:55–60. 1997. View Article : Google Scholar : PubMed/NCBI

10 

David S, Kümpers P, Hellpap J, et al: Angiopoietin 2 and cardiovascular disease in dialysis and kidney transplantation. Am J Kidney Dis. 53:770–778. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Vandenbunder B: Angiopoietin-2, a new molecular actor involved in vascular tree morphogenesis. Bull Cancer. 84:1079–1080. 1997.(In French).

12 

Augustin HG, Koh GY, Thurston G and Alitalo K: Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol. 10:165–177. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Chong AY, Caine GJ, Freestone B, Blann AD and Lip GY: Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure. J Am Coll Cardiol. 43:423–428. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Patel JV, Lim HS, Varughese GI, Hughes EA and Lip GY: Angiopoietin-2 levels as a biomarker of cardiovascular risk in patients with hypertension. Ann Med. 40:215–222. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Westra J, de Groot L, Plaxton SL, et al: Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease. Rheumatology (Oxford). 50:665–673. 2011. View Article : Google Scholar

16 

Lauver DA, Booth EA, White AJ, Poradosu E and Lucchesi BR: Sulodexide attenuates myocardial ischemia/reperfusion injury and the deposition of C-reactive protein in areas of infarction without affecting hemostasis. J Pharmacol Exp Ther. 312:794–800. 2005. View Article : Google Scholar

17 

Kim SB, Kim SH, Lee MS, Chang JW, Lee SK and Park JS: Effects of sulodexide on hemostatic factors, lipid profile, and inflammation in chronic peritoneal dialysis patients. Perit Dial Int. 27:456–460. 2007.PubMed/NCBI

18 

Shustov SB: Controlled clinical trial on the efficacy and safety of oral sulodexide in patients with peripheral occlusive arterial disease. Curr Med Res Opin. 13:573–582. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Lunetta M and Salanitri T: Lowering of plasma viscosity by the oral administration of the glycosaminoglycan sulodexide in patients with peripheral vascular disease. J Int Med Res. 20:45–53. 1992.PubMed/NCBI

20 

Rossini M, Naito T, Yang H, et al: Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. Nephrol Dial Transplant. 25:1803–1810. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Lin T, Horsfield C and Robson MG: Arteriovenous fistula in the rat tail: a new model of hemodialysis access dysfunction. Kidney Int. 74:528–531. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Bongrazio M, Baumann C, Zakrzewicz A, Pries AR and Gaehtgens P: Evidence for modulation of genes involved in vascular adaptation by prolonged exposure of endothelial cells to shear stress. Cardiovasc Res. 47:384–393. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Dixit M, Bess E, Fisslthaler B, et al: Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells. Cardiovasc Res. 77:160–168. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Park HY, Kang S, Kim GY, et al: Inhibition of neointimal proliferation of rat carotid artery by sulodexide. J Korean Med Sci. 12:210–214. 1997. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lei Y, Zheng Z, Wang Y, Liu Y, Liu R, Xu Q and Yu X: Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model. Mol Med Rep 7: 831-835, 2013.
APA
Lei, Y., Zheng, Z., Wang, Y., Liu, Y., Liu, R., Xu, Q., & Yu, X. (2013). Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model. Molecular Medicine Reports, 7, 831-835. https://doi.org/10.3892/mmr.2013.1293
MLA
Lei, Y., Zheng, Z., Wang, Y., Liu, Y., Liu, R., Xu, Q., Yu, X."Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model". Molecular Medicine Reports 7.3 (2013): 831-835.
Chicago
Lei, Y., Zheng, Z., Wang, Y., Liu, Y., Liu, R., Xu, Q., Yu, X."Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model". Molecular Medicine Reports 7, no. 3 (2013): 831-835. https://doi.org/10.3892/mmr.2013.1293
Copy and paste a formatted citation
x
Spandidos Publications style
Lei Y, Zheng Z, Wang Y, Liu Y, Liu R, Xu Q and Yu X: Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model. Mol Med Rep 7: 831-835, 2013.
APA
Lei, Y., Zheng, Z., Wang, Y., Liu, Y., Liu, R., Xu, Q., & Yu, X. (2013). Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model. Molecular Medicine Reports, 7, 831-835. https://doi.org/10.3892/mmr.2013.1293
MLA
Lei, Y., Zheng, Z., Wang, Y., Liu, Y., Liu, R., Xu, Q., Yu, X."Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model". Molecular Medicine Reports 7.3 (2013): 831-835.
Chicago
Lei, Y., Zheng, Z., Wang, Y., Liu, Y., Liu, R., Xu, Q., Yu, X."Sulodexide may alleviate neointimal hyperplasia by inhibiting angiopoietin‑2 in an arteriovenous fistula model". Molecular Medicine Reports 7, no. 3 (2013): 831-835. https://doi.org/10.3892/mmr.2013.1293
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team