Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April 2013 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2013 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Participation of CD34-enriched mouse adipose cells in hair morphogenesis

  • Authors:
    • Jing He
    • Huichuan Duan
    • Yao Xiong
    • Wenjie Zhang
    • Guangdong Zhou
    • Yilin Cao
    • Wei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, P.R. China, National Tissue Engineering Center of China, Shanghai, P.R. China
  • Pages: 1111-1116
    |
    Published online on: February 5, 2013
       https://doi.org/10.3892/mmr.2013.1307
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Adipose-derived stromal vascular fraction (SVF) cells are heterogeneous in nature, containing a number of different cell types. Recent studies indicate that CD34 may be a specific marker for adipose-derived mesenchymal stem cells (ADMSCs). Using their participation in hair morphogenesis as a model, the multi-differentiation potential of adult stem cells was investigated. In addition, adipose tissue or adipogenic lineage cells appear to be associated with the hair follicle cycle. The purpose of this study was to test the potential of CD34+ cells enriched from fat tissue in hair morphogenesis. To investigate this, unsorted SVF, CD34+ and CD34- cells sorted from the SVF of green fluorescence protein (GFP) transgenic mice were mixed with fetal mouse keratinocytes and dermal fibroblasts of gestational day 17.5 (E17.5) and then subcutaneously injected into nude mice. The results showed that in the reconstituted skin tissue, larger tissue blocks with more developed hair follicles were observed in the CD34+ cell group compared with the other two groups. Histological and immunofluorescent staining analyses revealed that only CD34+ cells may participate in hair morphogenesis by their integration into dermal sheath structures. However, no involvement in other skin appendages was observed. In addition, differentiation into endothelial cells and participation in blood vessel formation were also observed in both CD34+ and SVF cells, but not in CD34- cells. As expected, participation in adipogenesis was observed in all groups. Our results suggest that CD34+ cells may represent the ADMSCs which possess stronger multiple differentiation potential during reconstituted skin development.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Zuk PA, Zhu M, Mizuno H, et al: Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 7:211–228. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW and Gimble JM: Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol. 189:54–63. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Festa E, Fretz J, Berry R, et al: Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling. Cell. 146:761–771. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Chen HC, Smith SJ, Tow B, Elias PM and Farese RV Jr: Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J Clin Invest. 109:175–181. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Kataoka K, Medina RJ, Kageyama T, et al: Participation of adult mouse bone marrow cells in reconstitution of skin. Am J Pathol. 163:1227–1231. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Li H, Fu X, Ouyang Y, Cai C, Wang J and Sun T: Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages. Cell Tissue Res. 326:725–736. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Yoshimura K, Shigeura T, Matsumoto D, et al: Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol. 208:64–76. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Rodeheffer MS, Birsoy K and Friedman JM: Identification of white adipocyte progenitor cells in vivo. Cell. 135:240–249. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Tang W, Zeve D, Suh JM, et al: White fat progenitor cells reside in the adipose vasculature. Science. 322:583–586. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Pittenger MF, Mackay AM, Beck SC, et al: Multilineage potential of adult human mesenchymal stem cells. Science. 284:143–147. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Kuci S, Kuci Z, Latifi-Pupovci H, et al: Adult stem cells as an alternative source of multipotential (pluripotential) cells in regenerative medicine. Curr Stem Cell Res Ther. 4:107–117. 2009.PubMed/NCBI

12 

Kakinuma S, Tanaka Y, Chinzei R, et al: Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells. 21:217–227. 2003.PubMed/NCBI

13 

Wakitani S, Imoto K, Yamamoto T, Saito M, Murata N and Yoneda M: Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage. 10:199–206. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Guo W, Wang H, Zou S, et al: Bone marrow stromal cells produce long-term pain relief in rat models of persistent pain. Stem Cells. 29:1294–1303. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wagner W, Wein F, Seckinger A, et al: Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol. 33:1402–1416. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Aust L, Devlin B, Foster SJ, et al: Yield of human adipose-derived adult stem cells from liposuction aspirates. Cytotherapy. 6:7–14. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Varma MJ, Breuls RG, Schouten TE, et al: Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cells Dev. 16:91–104. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Afizah H, Yang Z, Hui JH, Ouyang HW and Lee EH: A comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors. Tissue Eng. 13:659–666. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Lin G, Garcia M, Ning H, et al: Defining stem and progenitor cells within adipose tissue. Stem Cells Dev. 17:1053–1063. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Traktuev DO, Merfeld-Clauss S, Li J, et al: A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res. 102:77–85. 2008. View Article : Google Scholar

21 

Hardy MH: The secret life of the hair follicle. Trends Genet. 8:55–61. 1992. View Article : Google Scholar : PubMed/NCBI

22 

Chase HB, Montagna W and Malone JD: Changes in the skin in relation to the hair growth cycle. Anat Rec. 116:75–81. 1953. View Article : Google Scholar : PubMed/NCBI

23 

Hansen LS, Coggle JE, Wells J and Charles MW: The influence of the hair cycle on the thickness of mouse skin. Anat Rec. 210:569–573. 1984. View Article : Google Scholar : PubMed/NCBI

24 

Jong MC, Gijbels MJ, Dahlmans VE, et al: Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1. J Clin Invest. 101:145–152. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Stone SJ, Myers HM, Watkins SM, et al: Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 279:11767–11776. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Biernaskie J, Paris M, Morozova O, et al: SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Cell Stem Cell. 5:610–623. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Yoo BY, Shin YH, Yoon HH, Seo YK, Song KY and Park JK: Application of mesenchymal stem cells derived from bone marrow and umbilical cord in human hair multiplication. J Dermatol Sci. 60:74–83. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Yamao M, Inamatsu M, Ogawa Y, et al: Contact between dermal papilla cells and dermal sheath cells enhances the ability of DPCs to induce hair growth. J Invest Dermatol. 130:2707–2718. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Tobin DJ, Gunin A, Magerl M, Handijski B and Paus R: Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control. J Invest Dermatol. 120:895–904. 2003. View Article : Google Scholar : PubMed/NCBI

30 

McElwee KJ, Kissling S, Wenzel E, Huth A and Hoffmann R: Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. J Invest Dermatol. 121:1267–1275. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He J, Duan H, Xiong Y, Zhang W, Zhou G, Cao Y and Liu W: Participation of CD34-enriched mouse adipose cells in hair morphogenesis. Mol Med Rep 7: 1111-1116, 2013.
APA
He, J., Duan, H., Xiong, Y., Zhang, W., Zhou, G., Cao, Y., & Liu, W. (2013). Participation of CD34-enriched mouse adipose cells in hair morphogenesis. Molecular Medicine Reports, 7, 1111-1116. https://doi.org/10.3892/mmr.2013.1307
MLA
He, J., Duan, H., Xiong, Y., Zhang, W., Zhou, G., Cao, Y., Liu, W."Participation of CD34-enriched mouse adipose cells in hair morphogenesis". Molecular Medicine Reports 7.4 (2013): 1111-1116.
Chicago
He, J., Duan, H., Xiong, Y., Zhang, W., Zhou, G., Cao, Y., Liu, W."Participation of CD34-enriched mouse adipose cells in hair morphogenesis". Molecular Medicine Reports 7, no. 4 (2013): 1111-1116. https://doi.org/10.3892/mmr.2013.1307
Copy and paste a formatted citation
x
Spandidos Publications style
He J, Duan H, Xiong Y, Zhang W, Zhou G, Cao Y and Liu W: Participation of CD34-enriched mouse adipose cells in hair morphogenesis. Mol Med Rep 7: 1111-1116, 2013.
APA
He, J., Duan, H., Xiong, Y., Zhang, W., Zhou, G., Cao, Y., & Liu, W. (2013). Participation of CD34-enriched mouse adipose cells in hair morphogenesis. Molecular Medicine Reports, 7, 1111-1116. https://doi.org/10.3892/mmr.2013.1307
MLA
He, J., Duan, H., Xiong, Y., Zhang, W., Zhou, G., Cao, Y., Liu, W."Participation of CD34-enriched mouse adipose cells in hair morphogenesis". Molecular Medicine Reports 7.4 (2013): 1111-1116.
Chicago
He, J., Duan, H., Xiong, Y., Zhang, W., Zhou, G., Cao, Y., Liu, W."Participation of CD34-enriched mouse adipose cells in hair morphogenesis". Molecular Medicine Reports 7, no. 4 (2013): 1111-1116. https://doi.org/10.3892/mmr.2013.1307
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team