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Article

Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus

  • Authors:
    • Feihua Wu
    • Zhigui Jin
    • Jian Jin
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Huangpu, Shanghai 200011, P.R. China
  • Pages: 1278-1282
    |
    Published online on: February 19, 2013
       https://doi.org/10.3892/mmr.2013.1330
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Abstract

The present study was designed to investigate the hypoglycemic effects of glabridin from licorice in an animal model of diabetes mellitus (DM). Male Kunming mice were used to induce DM using streptozotocin (STZ). After confirmation of the diabetic state, the mice were randomly divided into six groups of 10 animals each: normal control (NC), diabetic control (DC), diabetic + low-dose glabridin treatment (DLG) (glabridin, 10 mg/kg), diabetic + medium‑dose glabridin treatment (DMG) (glabridin, 20 mg/kg), diabetic + high-dose glabridin treatment (DHG) (glabridin, 40 mg/kg) and diabetic + glyburide treatment group (DG) (glyburide, 4 mg/kg). Each treatment was continued daily for 28 days, and then body weight, fasting blood glucose (FBG), glucose tolerance, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. The data obtained showed that glabridin significantly increased body weight, glucose tolerance and SOD activities in the liver, kidney and pancreas, while decreasing FBG levels and MDA content in the liver, kidney and pancreas. These results demonstrated that glabridin possesses hypoglycemic effects.
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1 

El-Alfy AT, Ahmed AA and Fatani SAJ: Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats. Pharmacol Res. 52:264–270. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Li F, Tang H, Xiao F, et al: Protective effect of salidroside from Rhodiolae radix on diabetes-induced oxidative stress in mice. Molecules. 16:9912–9924. 2011.

3 

Zhang ZF, Lv GY, Pan HJ, et al: Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture. Braz Arch Biol Technol. 54:701–708. 2011. View Article : Google Scholar

4 

Li WL, Zheng HC, Bukuru J and De Kimpe N: Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol. 92:1–21. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Tang LQ, Wei W, Chen LM and Liu S: Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol. 108:109–115. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Luo Q, Cai Y, Yan J, et al: Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 76:137–149. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Lü H, Chen J, Li WL, et al: Hypoglycemic effect of the total flavonoid fraction from folium Eriobotryae. Phytomedicine. 16:967–971. 2009.PubMed/NCBI

8 

Liu Z, Wang LJ, Li X, et al: Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. Phytother Res. 23:1426–1430. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Qi LW, Liu EH, Chu C, et al: Anti-diabetic agents from natural products - an update from 2004 to 2009. Curr Top Med Chem. 10:434–457. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Patel MB and Mishra S: Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine. 18:1045–1052. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Tian ML, Yan HY and Row KH: Simultaneous extraction and separation of liquiritin, glycyrrhizic acid, and glabridin from licorice root with analytical and preparative chromatography. Biotechnol Bioprocess Eng. 13:671–676. 2008. View Article : Google Scholar

12 

Sabbioni C, Mandrioli R, Ferranti A, et al: Separation and analysis of glycyrrhizin, 18beta-glycyrrhetic acid and 18alpha-glycyrrhetic acid in liquorice roots by means of capillary zone electrophoresis. J Chromatogr A. 1081:65–71. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Mori H, Niwa K, Zheng Q, et al: Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells. Mutat Res. 480–481:201–207. 2001.

14 

Yokozawa T, Cho EJ, Rhyu DY, et al: Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration. Free Radic Res. 39:203–211. 2005. View Article : Google Scholar

15 

Lee JY, Lee JH, Park JH, et al: Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not. Int Immunopharmacol. 9:632–638. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Shang H, Cao S, Wang J, et al: Glabridin from Chinese herb licorice inhibits fatigue in mice. Afr J Tradit Complement Altern Med. 7:17–23. 2009.PubMed/NCBI

17 

Choi EM: The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. Biochem Pharmacol. 70:363–368. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Sharma S, Kulkarni SK, Agrewala JN and Chopra K: Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pharmacol. 536:256–261. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Hwang HJ, Kim SW, Lim JM, et al: Hypoglycemic effect of crude exopolysaccharides produced by a medicinal mushroom Phellinus baumii in streptozotocin-induced diabetic rats. Life Sci. 76:3069–3080. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Hayashi K, Kojima R and Ito M: Strain differences in the diabetogenic activity of streptozotocin in mice. Biol Pharm Bull. 29:1110–1119. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Sarkhail P, Rahmanipour S, Fadyevatan S, et al: Antidiabetic effect of Phlomis anisodonta: effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Pharmacol Res. 56:261–266. 2007.

22 

Li F, Li Q, Gao D and Peng Y: The optimal extraction parameters and anti-diabetic activity of flavonoids from Ipomoea batatas leaf. Afr J Tradit Complement Altern Med. 6:195–202. 2009.PubMed/NCBI

23 

Li F, Zhang Y and Zhong Z: Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice. Int J Mol Sci. 12:6135–6145. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Raghavan B and Kumari SK: Effect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats. Indian J Physiol Pharmacol. 50:133–142. 2006.

25 

Ha H, Hwang IA, Park JH and Lee HB: Role of reactive oxygen species in the pathogenesis of diabetic nephropathy. Diabetes Res Clin Pract. 82(Suppl 1): S42–S45. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Cemek M, Kağa S, Simşek N, et al: Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats. J Nat Med. 62:284–293. 2008.

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Copy and paste a formatted citation
Spandidos Publications style
Wu F, Jin Z and Jin J: Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. Mol Med Rep 7: 1278-1282, 2013.
APA
Wu, F., Jin, Z., & Jin, J. (2013). Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. Molecular Medicine Reports, 7, 1278-1282. https://doi.org/10.3892/mmr.2013.1330
MLA
Wu, F., Jin, Z., Jin, J."Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus". Molecular Medicine Reports 7.4 (2013): 1278-1282.
Chicago
Wu, F., Jin, Z., Jin, J."Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus". Molecular Medicine Reports 7, no. 4 (2013): 1278-1282. https://doi.org/10.3892/mmr.2013.1330
Copy and paste a formatted citation
x
Spandidos Publications style
Wu F, Jin Z and Jin J: Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. Mol Med Rep 7: 1278-1282, 2013.
APA
Wu, F., Jin, Z., & Jin, J. (2013). Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. Molecular Medicine Reports, 7, 1278-1282. https://doi.org/10.3892/mmr.2013.1330
MLA
Wu, F., Jin, Z., Jin, J."Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus". Molecular Medicine Reports 7.4 (2013): 1278-1282.
Chicago
Wu, F., Jin, Z., Jin, J."Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus". Molecular Medicine Reports 7, no. 4 (2013): 1278-1282. https://doi.org/10.3892/mmr.2013.1330
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