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Molecular Medicine Reports
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Article

microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line

  • Authors:
    • Yan Wang
    • Xiaodong Gu
    • Zhenyang Li
    • Jianbin Xiang
    • Jianhai Jiang
    • Zongyou Chen
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Key Laboratory of Glycoconjugate Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, P.R. China
  • Pages: 1506-1510
    |
    Published online on: March 20, 2013
       https://doi.org/10.3892/mmr.2013.1384
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Abstract

The present study aimed to identify microRNA (miRNA) expression profiles associated with multidrug resistance (MDR) in gastric carcinoma. A 5‑fluorouracil (5‑Fu)‑induced MDR gastric cancer cell line was selected and miRNA expression profiling of the cell line was conducted following exposure to 5‑Fu. The miRNA expression profiles between the parental and resistant gastric cancer cells were analyzed by Human miRNA OneArray® v3 and the results were confirmed by quantitative real‑time RT‑PCR. The expression of 9 miRNAs (miR‑10b, ‑22, ‑31, ‑133b, ‑190, ‑501, ‑615, ‑501‑5p and ‑615‑5p) was upregulated while the expression of 18 additional miRNAs (miR‑32, ‑197, ‑210, ‑766, ‑1229, ‑1238, ‑3131, ‑3149, ‑1224‑3p, ‑3162‑3p, ‑532, ‑877, ‑4701‑5p, ‑5096, ‑4728‑3p, ‑1273d, ‑486‑3p and‑4763‑3p) was downregulated in the SGC‑7901/5‑Fu cell line compared with its parental cell line. The results indicate that miRNA expression correlates with MDR in gastric cancer and may serve as biomolecular targets for MDR elimination.
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1 

Zhao P, Dai M, Chen W and Li N: Cancer trends in China. Jpn J Clin Oncol. 40:281–285. 2010. View Article : Google Scholar

2 

Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar

3 

de Bree E, Charalampakis V, Melissas J and Tsiftsis DD: The extent of lymph node dissection for gastric cancer: a critical appraisal. J Surg Oncol. 102:552–562. 2010.

4 

Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science. 294:853–858. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Cheng AM, Byrom MW, Shelton J and Ford LP: Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 33:1290–1297. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Blower PE, Chung JH, Verducci JS, et al: MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther. 7:1–9. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Zheng T, Wang J, Chen X and Liu L: Role of microRNA in anticancer drug resistance. Int J Cancer. 126:2–10. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Sarkar FH, Li Y, Wang Z, Kong D and Ali S: Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Updat. 13:57–66. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Rossi L, Bonmassar E and Faraoni I: Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro. Pharmacol Res. 56:248–253. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Nakajima G, Hayashi K, Xi Y, et al: Non-coding microRNAs hsa-let-7g and hsa-miR-181b are associated with chemoresponse to S-1 in colon cancer. Cancer Genomics Proteomics. 3:317–324. 2006.PubMed/NCBI

11 

Rosenfeld N, Aharonov R, Meiri E, et al: MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol. 26:462–469. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Schmittgen TD, Lee EJ, Jiang J, et al: Real-time PCR quantification of precursor and mature microRNA. Methods. 44:31–38. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Luqmani YA: Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract. 14(Suppl 1): 35–48. 2005. View Article : Google Scholar

14 

Ganguly A, Banerjee K, Chakraborty P, et al: Overcoming multidrug resistance (MDR) in cancer in vitro and in vivo by a quinoline derivative. Biomed Pharmacother. 65:387–394. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Gottesman MM and Pastan I: The multidrug transporter, a double-edged sword. J Biol Chem. 263:1263–1266. 1988.PubMed/NCBI

16 

Moscow JA and Cowan KH: Multidrug resistance. J Natl Cancer Inst. 80:14–20. 1988. View Article : Google Scholar : PubMed/NCBI

17 

Watson MB, Lind MJ and Cawkwell L: Establishment of in-vitro models of chemotherapy resistance. Anticancer Drugs. 18:749–754. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Singh R and Lillard JW Jr: Nanoparticle-based targeted drug delivery. Exp Mol Pathol. 86:215–223. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Hammond SM, Bernstein E, Beach D and Hannon GJ: An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 404:293–296. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Fujita Y, Kojima K, Hamada N, et al: Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells. Biochem Biophys Res Commun. 377:114–119. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Northcott PA, Fernandez-L A, Hagan JP, et al: The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res. 69:3249–3255. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Li Y, Li W, Yang Y, et al: MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res. 1286:13–18. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Xia L, Zhang D, Du R, et al: miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int J Cancer. 123:372–379. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 449:682–688. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Gee HE, Camps C, Buffa FM, et al: MicroRNA-10b and breast cancer metastasis. Nature. 455:E8–E9. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Li G, Wu Z, Peng Y, et al: MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells. Cancer Lett. 299:29–36. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Kakarala M, Brenner DE, Korkaya H, et al: Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat. 122:777–785. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Gu X, Li Z, Xiang J, Jiang J and Chen Z: microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line. Mol Med Rep 7: 1506-1510, 2013.
APA
Wang, Y., Gu, X., Li, Z., Xiang, J., Jiang, J., & Chen, Z. (2013). microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line. Molecular Medicine Reports, 7, 1506-1510. https://doi.org/10.3892/mmr.2013.1384
MLA
Wang, Y., Gu, X., Li, Z., Xiang, J., Jiang, J., Chen, Z."microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line". Molecular Medicine Reports 7.5 (2013): 1506-1510.
Chicago
Wang, Y., Gu, X., Li, Z., Xiang, J., Jiang, J., Chen, Z."microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line". Molecular Medicine Reports 7, no. 5 (2013): 1506-1510. https://doi.org/10.3892/mmr.2013.1384
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Gu X, Li Z, Xiang J, Jiang J and Chen Z: microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line. Mol Med Rep 7: 1506-1510, 2013.
APA
Wang, Y., Gu, X., Li, Z., Xiang, J., Jiang, J., & Chen, Z. (2013). microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line. Molecular Medicine Reports, 7, 1506-1510. https://doi.org/10.3892/mmr.2013.1384
MLA
Wang, Y., Gu, X., Li, Z., Xiang, J., Jiang, J., Chen, Z."microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line". Molecular Medicine Reports 7.5 (2013): 1506-1510.
Chicago
Wang, Y., Gu, X., Li, Z., Xiang, J., Jiang, J., Chen, Z."microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line". Molecular Medicine Reports 7, no. 5 (2013): 1506-1510. https://doi.org/10.3892/mmr.2013.1384
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