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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May 2013 Volume 7 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Apelin elevates blood pressure in ICR mice with L‑NAME‑induced endothelial dysfunction

Katsumasa Nagano, Junji Ishida, Madoka Unno, Tanomu Matsukura, Akiyoshi Fukamizu
Pages: 1371-1375
Published online on: 15 March 2013

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Article

Expression and biological role of CIP2A in human astrocytoma

Fuxin Yi, Weimin Ni, Weixian Liu, Jinyang Bai, Wenbin Li
Pages: 1376-1380
Published online on: 05 March 2013

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Article Open Access

Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer

Hideki Tani, Noboru Saito, Makio Kobayashi, Shingo Kameoka
Pages: 1381-1386
Published online on: 27 March 2013

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Article

Overexpression of AKT decreases the chemosensitivity of gastric cancer cells to cisplatin in vitro and in vivo

Ling-li Zhang, Jun Zhang, Lei Shen, Xi-ming Xu, Hong-gang Yu
Pages: 1387-1390
Published online on: 28 March 2013

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Article

Combined CT angiography and SPECT myocardial perfusion imaging for the detection of functionally relevant coronary stenoses

Jian‑Ming Li, Rong‑Fang Shi, Li‑Ren Zhang, Ting Li, Zhi Dong
Pages: 1391-1396
Published online on: 04 March 2013

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Article

In vivo dynamic monitoring of the biological behavior of labeled C6 glioma by MRI

Jichun Liao, Rui Xia, Ting Liu, Hua Feng, Hua Ai, Bin Song, Fabao Gao
Pages: 1397-1402
Published online on: 13 March 2013

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Article

Crude extract of Euphorbia formosana inhibits the migration and invasion of DU145 human prostate cancer cells: The role of matrix metalloproteinase-2/9 inhibition via the MAPK signaling pathway

Jiun-Long Yang, Ju-Hwa Lin, Shu-Wen Weng, Jaw-Chyun Chen, Jai-Sing Yang, Sakae Amagaya, Shinji Funayana, W. Gibson Wood, Chao-Lin Kuo, Jing-Gung Chung
Pages: 1403-1408
Published online on: 20 March 2013

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Article

Overexpression of hTERT in potentially malignant colorectal laterally spreading tumors

Jun Li, Xun Cao, Yi Fang, Zhen-Er Liao, Yu-Ying Liu, Bi-Dan Huang, Yu-Jing Han
Pages: 1409-1412
Published online on: 15 March 2013

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Article

Expression and significance of PTEN and miR-92 in hepatocellular carcinoma

Bin Zhao, Yueting Zhu, Kai Cui, Jie Gao, Fachang Yu, Liang Chen, Sheng Li
Pages: 1413-1416
Published online on: 28 March 2013

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Article

Genome‑wide analysis of DNA methylation in rat lungs with lipopolysaccharide‑induced acute lung injury

Xiao‑Qiang Zhang, Chang‑Jun Lv, Xiang‑Yong Liu, Dong Hao, Jing  Qin, Huan‑Huan Tian, Yan Li, Xiao‑Zhi Wang
Pages: 1417-1424
Published online on: 28 March 2013

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Article

Effects of paeonol on intracellular calcium concentration and expression of RUNX3 in LoVo human colon cancer cells

Ming Li, Shi‑Yun Tan, Jun Zhang, Hong‑Xia You
Pages: 1425-1430
Published online on: 14 March 2013

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Article

Temporospatial expression and cellular localization of glutamine synthetase following traumatic spinal cord injury in adult rats

Chunxing Liu, Wenjie Wu, Bin Zhang, Jie Xiang, Jian Zou
Pages: 1431-1436
Published online on: 20 March 2013

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Article

A novel chimeric peptide binds MC3T3‑E1 cells to titanium and enhances their proliferation and differentiation

Dan Wang, Xiaofu Liao, Xu Qin, Wei Shi, Bin Zhou
Pages: 1437-1441
Published online on: 01 March 2013

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Article

Transcriptomic and proteomic analysis of human hepatic stellate cells treated with natural taurine

Jian Liang, Xin Deng, Fa-Sheng Wu, Yan-Fang Tang
Pages: 1442-1452
Published online on: 20 March 2013

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Article

Amygdalin inhibits renal fibrosis in chronic kidney disease

Junqi Guo, Weizheng Wu, Mingxiong Sheng, Shunliang Yang, Jianming Tan
Pages: 1453-1457
Published online on: 22 March 2013

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Article

Distribution of lymphatic tissues and autonomic nerves in supporting ligaments around the cervix uteri

Jianping Zhang, Lanlan Feng, Yi Lu, Dongxia Guo, Tengteng Xi, Xiaochun Wang
Pages: 1458-1464
Published online on: 06 March 2013

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Article

Cardiomyocyte differentiation of perinatally‑derived mesenchymal stem cells

Kuneerat Nartprayut, Yaowalak U‑Pratya, Pakpoom Kheolamai, Sirikul Manochantr, Methichit Chayosumrit, Surapol Issaragrisil, Aungkura Supokawej
Pages: 1465-1469
Published online on: 04 March 2013

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Article

Levels of leptin and IL-6 in lungs and blood are associated with the severity of chronic obstructive pulmonary disease in patients and rat models

Rui Liang, Wei Zhang, Ya-Mei Song
Pages: 1470-1476
Published online on: 15 March 2013

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Article

Overexpression of C10orf116 promotes proliferation, inhibits apoptosis and enhances glucose transport in 3T3-L1 adipocytes

Ling Chen, Xiao-Guang Zhou, Xiao-Yu Zhou, Chun Zhu, Chen-Bo Ji, Chun-Mei Shi, Jie Qiu, Xi-Rong Guo
Pages: 1477-1481
Published online on: 01 March 2013

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Article

Expression of 11β-HSD in steroid-induced avascular necrosis of the femoral head

Lin Wang, Deng-Ke Luo, Zhen-Yu Pan
Pages: 1482-1486
Published online on: 28 March 2013

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Article

Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-α, Caspase-8, Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro

Yao-Li Chen, Meng-Yi Yan, Su-Yu Chien, Shou-Jen Kuo, Dar‑Ren Chen, Chun-Yuan Cheng, Chin-Cheng Su
Pages: 1487-1493
Published online on: 20 March 2013

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Article

Expression of basigin in the early phase of acute myocardial ischemia in rats

Yun Liu, Wei‑Bo Liang, Lu‑Shun Zhang, Lin‑Bo Gao, Tian‑Yi Chen, Yan‑Yun Wang, Lin Zhang
Pages: 1494-1500
Published online on: 20 March 2013

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Article

Knockdown of autophagy-related gene BECLIN1 promotes cell growth and inhibits apoptosis in the A549 human lung cancer cell line

Wenyu Wang, Hongkun Fan, Yun Zhou, Ping Duan, Guoqiang Zhao, Gang Wu
Pages: 1501-1505
Published online on: 19 March 2013

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Article

microRNA expression profiling in multidrug resistance of the 5‑Fu‑induced SGC‑7901 human gastric cancer cell line

Yan Wang, Xiaodong Gu, Zhenyang Li, Jianbin Xiang, Jianhai Jiang, Zongyou Chen
Pages: 1506-1510
Published online on: 20 March 2013

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Article

Synergistic protective effects of escin and low‑dose glucocorticoids on blood‑retinal barrier breakdown in a rat model of retinal ischemia

Fenglan Zhang, Yuanbin Li, Leiming Zhang, Guoying Mu
Pages: 1511-1515
Published online on: 15 March 2013

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Article

Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats

Xiaodong Feng, Shanli Yang, Jiao Liu, Jia Huang, Jun Peng, Jiumao Lin, Jing Tao, Lidian Chen
Pages: 1516-1522
Published online on: 22 March 2013

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Article

Electrical stimulation enhances peripheral nerve regeneration after crush injury in rats

Xu Zhang, Na Xin, Lei Tong, Xiao-Jie Tong
Pages: 1523-1527
Published online on: 26 March 2013

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Article

Effects of different states of oxidative stress on fetal rat alveolar type II epithelial cells in vitro and ROS‑induced changes in Wnt signaling pathway expression

Zhu Li, Fang Fang, Feng Xu
Pages: 1528-1532
Published online on: 20 March 2013

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Article

Effects of matrine on oval cell‑mediated liver regeneration and expression of RBP‑Jκ and HES1

Zhi‑Yun Yang, Li Wang, Yi‑Xin Hou, Xian‑Bo Wang
Pages: 1533-1538
Published online on: 27 March 2013

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Article

The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells

Yu-Ren Liao, Chi-Cheng Lu, Kuang-Chi Lai, Jai-Sing Yang, Sheng‑Chu Kuo, Yen-Fang Wen, Shinji Fushiya, Tian-Shung Wu
Pages: 1539-1544
Published online on: 05 March 2013

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Article

A unique case of female pseudohermaphroditism with 21-hydroxylase deficiency and small supernumerary marker chromosome 7

Walid Al-Achkar, Abdulsamad Wafa, Manar Assaad, Christian Ehlers, Thomas Liehr
Pages: 1545-1548
Published online on: 28 February 2013

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Article

Paired box 2 induces epithelial-mesenchymal transition in normal renal tubular epithelial cells of rats

Li Li, Yubin Wu, Yongchang Yang
Pages: 1549-1554
Published online on: 12 March 2013

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Article

Antitumor activity of bee pollen polysaccharides from Rosa rugosa

Bo Wang, Qiyu Diao, Zhongyu Zhang, Yang Liu, Qipin Gao, Yifa Zhou, Shanshan Li
Pages: 1555-1558
Published online on: 20 March 2013

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Article

The mechanism through which octreotide inhibits hepatic stellate cell activity

Jingjing Wang, Lin Wang, Guanhua Song, Bo Han
Pages: 1559-1564
Published online on: 20 March 2013

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Article

Morroniside promotes bone marrow mesenchymal stem cell proliferation in rats

Naiwu Hu, Shujun Ren, Wei Li, Tao Zhang, Chengbin Zhao
Pages: 1565-1570
Published online on: 28 March 2013

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Article

Alzheimer's phenotypes induced by overexpression of human presenilin 2 mutant proteins stimulate significant changes in key factors of glucose metabolism

Young Ju Lee, Ji Eun Kim, In Sik Hwang, Moon Hwa Kwak, Jae Ho Lee, Young Jin Jung, Beum Soo An, Hyeog Soong Kwon, Byoung Chul Kim, Seon Jong Kim, Joo Man Kim, Dae Youn Hwang
Pages: 1571-1578
Published online on: 28 March 2013

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Article

miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling

Yong Chen, Ying Sun, Longbang Chen, Xingxiang Xu, Xizhi Zhang, Buhai Wang, Lingfeng Min, Wei Liu
Pages: 1579-1584
Published online on: 28 March 2013

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Article

Bigelovii A induces apoptosis of HL‑60 human acute promyelocytic leukaemia cells

Fuqin Guan, Haiting Wang, Yu Shan, Dongmei Zhang, Youyi Zhao, Yu Chen, Qizhi Wang, Ming Wang, Xu Feng
Pages: 1585-1590
Published online on: 01 March 2013

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Article

Differentially expressed kinase genes associated with trypsinogen activation in rat pancreatic acinar cells treated with taurolithocholic acid 3-sulfate

Biao Ma, Lin Wu, Ming Lu, Bo Gao, Xin Qiao, Bei Sun, Dongbo Xue, Weihui Zhang
Pages: 1591-1596
Published online on: 04 March 2013

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Article

The viable Mycobacterium tuberculosis H37Ra strain induces a stronger mouse macrophage response compared to the heat-inactivated H37Rv strain

Zong-Lin He, Fa-Wang Du, Xian-Zhi Du
Pages: 1597-1602
Published online on: 08 March 2013

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Article

High-flux dialysis improves pulmonary ventilation function in uremic patients

Hui Lin, Yong-Gui Wu, Jiang-Huai Zhang, Ming Kan
Pages: 1603-1606
Published online on: 14 March 2013

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Article

Protective effects of Lagerstroemia speciosa on 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in HIT-T15 pancreatic β cells

Jia-Le Song, Xin Zhao, Qiang Wang, Ting Zhang
Pages: 1607-1612
Published online on: 26 March 2013

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Article

Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats

Xin Zhao, Qiang Wang, Yu Qian, Jia-Le Song
Pages: 1613-1616
Published online on: 28 March 2013

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Article

Mesenchymal stem cells overexpressing integrin-linked kinase attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions

Qing Mao, Cheng-Xi Lin, Xiu-Lin Liang, Jian-Shu Gao, Biao Xu
Pages: 1617-1623
Published online on: 28 February 2013

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Article

Effects of Bauhinia championii (Benth.) Benth. polysaccharides on the proliferation and cell cycle of chondrocytes

Liangliang Cai, Hongzhi Ye, Fangrong Yu, Huiting Li, Jiashou Chen, Xianxiang Liu
Pages: 1624-1630
Published online on: 13 March 2013

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Article

DNA integrity is a critical molecular indicator for the assessment of male infertility

Huda Mossa Omran, Moiz Bakhiet, Mariam Ghloom Dashti
Pages: 1631-1635
Published online on: 21 March 2013

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Article

The effect of telomerase activity on vascular smooth muscle cell proliferation in type 2 diabetes in vivo and in vitro

Xiaodong Sun, Fang Han, Junling Yi, Ningning Hou, Zhibin Cao
Pages: 1636-1640
Published online on: 28 February 2013

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Article

NS-398 enhances the efficacy of bortezomib against RPMI8226 human multiple myeloma cells

Wenzhong Que, Saiyuan Li, Junmin Chen
Pages: 1641-1645
Published online on: 26 March 2013

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Article

Signaling network of OSW‑1‑induced apoptosis and necroptosis in hepatocellular carcinoma

Jichun Jin, Xinglin Jin, Changshi Qian, Yang Ruan , Hao Jiang
Pages: 1646-1650
Published online on: 13 March 2013

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Article

RNA interference‑mediated inhibition of survivin and VEGF in pancreatic cancer cells in vitro

Jianlin Song, Lipin Cao, Yixiong Li
Pages: 1651-1655
Published online on: 06 March 2013

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Article

The pyrimidine analog FNC inhibits cell proliferation and viral protein synthesis in HTLV‑1‑infected cells

Jinheng Wang, Xia Wang, Cai Gao, Xiangfeng Song, Zhiguo Niu, Zhitao Gao, Zhihai Qin, Junbiao Chang, Hui Wang
Pages: 1656-1660
Published online on: 05 March 2013

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Article

Activation of spinal ERK1/2 contributes to mechanical allodynia in a rat model of postoperative pain

Xu‑Dan Shi, Di Fu, Jun‑Mei Xu, Yan‑Ling Zhang, Ru‑Ping Dai
Pages: 1661-1665
Published online on: 28 February 2013

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Article

Interaction between cAMP, volume‑regulated anion channels and the Na+‑HCO3‑‑cotransporter, NBCe1, in the regulation of nutrient‑ and hypotonicity‑induced insulin release from isolated rat pancreatic islets and tumoral insulin‑producing BRIN‑BD11 cells

Nurdan Bulur, Raphael Crutzen, Willy J. Malaisse, Abdullah Sener, Renaud Beauwens, Philippe Golstein
Pages: 1666-1672
Published online on: 28 February 2013

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Article

Ursolic acid induces apoptosis via Akt/NF-κB signaling suppression in T24 human bladder cancer cells

Long Gai, Na Cai, Lingling Wang, Xiaoyi Xu, Xiangbo Kong
Pages: 1673-1677
Published online on: 11 March 2013

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Article

Overexpression of high mobility group protein B1 correlates with the proliferation and metastasis of lung adenocarcinoma cells

Ke-Kang Sun, Cheng Ji, Xing Li, Lu Zhang, Jun Deng, Ning Zhong, Xiao-Yang Wu
Pages: 1678-1682
Published online on: 06 March 2013

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Article

Effects of edaravone on the expression of β-defensin-2 mRNA in lung tissue of rats with myocardial ischemia reperfusion

Weiwei Zhang, Yongqing Guo, Shuzhen Yu, Jianfeng Wei, Jianmin Jin
Pages: 1683-1687
Published online on: 22 March 2013

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Article

siRNA targeting of PRDX3 enhances cisplatin‑induced apoptosis in ovarian cancer cells through the suppression of the NF‑κB signaling pathway

Jie Duan, Yan Lang, Chengwen Song, Jun Xiong, Yan Wang, Yang Yan
Pages: 1688-1694
Published online on: 14 March 2013

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Article

Transforming growth factor-β1 gene mutations and phenotypes in pediatric patients with Camurati‑Engelmann disease

Chun Wang, Bao-Hong Zhang, Yu-Juan Liu, Yun-Qiu Hu, Jin-Wei He, Zhen-Lin Zhang
Pages: 1695-1699
Published online on: 13 March 2013

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Article

Comparative proteomic analysis of ductal breast carcinoma demonstrates an altered expression of chaperonins and cytoskeletal proteins

Paolo Carcoforo, Blendi Ura, Carlo Mischiati, Monica Squerzanti, Vincenzo Lanzara, Carlo Cervellati, Roberta Calza, Patrizia Polverino De Laureto, Erica Frare, Mattia Portinari, Giordana Feriotto, Serena Lanzara, Enzo Agostinelli, Carlo M. Bergamini
Pages: 1700-1704
Published online on: 15 March 2013

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Article

Effect of histone deacetylase inhibitors on cell apoptosis and expression of the tumor suppressor genes RUNX3 and ARHI in ovarian tumors

Lan Zhang, Peishu Liu, Hua Li, Fuying Xue
Pages: 1705-1709
Published online on: 14 March 2013

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Article

Developmental delay referrals and the roles of Fragile X testing and molecular karyotyping: A New Zealand perspective

Elaine Doherty, Rachel O'Connor, Anna Zhang, Christina Lim, Jennifer M. Love, Fern Ashton, Karen Claxton, Nerine Gregersen, Alice M. George, Donald R. Love
Pages: 1710-1714
Published online on: 20 March 2013

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

Yihe Ma, Ye Chen, Yuhui Liang, Yun Huang, Miao Gong, Lifeng Tian, Xiaojun Xiao, Jingyan Liu, Qinmiao Huang
Article Number: 77
Published online on: 31 December 2025

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Article Open Access

Role and mechanism of miR‑222‑5p in endothelial cell apoptosis

Shimeng Wang, Boxin Zhao, Ying Cui, Lin Gui, Jingyao Fan, Lijuan Huang
Article Number: 76
Published online on: 31 December 2025

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Expression of Concern Open Access

[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
Published online on: 22 December 2025

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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
Article Number: 74
Published online on: 22 December 2025

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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
Published online on: 18 December 2025

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Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

Aihong Wu, Yuan Wang, Feifei Liu, Zhoufang Cao, Shuhui Du, Mengyu Sun
Article Number: 72
Published online on: 18 December 2025

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CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
Published online on: 17 December 2025

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Expression of Concern Open Access

[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

Tsai-Ching Hsu, Chih-Chen Tzang, Chia-Wei Kuo, Zhi-Han Wen, Der-Yuan Chen, Bor-Show Tzang
Article Number: 69
Published online on: 16 December 2025

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Review Open Access

Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
Published online on: 16 December 2025

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Retraction Open Access

[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Review Open Access

Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Review Open Access

Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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Expression of Concern Open Access

[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Review Open Access

Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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Retraction Open Access

[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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Article Open Access

ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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Article

MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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Correction Open Access

[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Article Open Access

Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Review Open Access

Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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Article Open Access

lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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March-2026 Volume 33 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies 
(Review)

Yifei Chen, Zhaohui Zhang, Gaosheng Zhou
Article Number: 98
Published online on: 22 January 2026

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HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis

Wenwen Han, Hongli Chen, Bomiao Cui, Jiao Chen, Ping Zhang, Yun Feng
Article Number: 97
Published online on: 22 January 2026

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Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

Miaomiao Wu, Yating An, Yongmin Li, Wei He, Ying Wang, Yaqi Wang, Caixia Wu
Article Number: 96
Published online on: 22 January 2026

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PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

Chen Zhou, Yifei Wang, Jie Zhao, Yantao Yang, Yuhang Yuan, Xiaochen Hou, Yu Tang, Lianhua Ye
Article Number: 95
Published online on: 22 January 2026

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Retraction Open Access

[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Review Open Access

Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Article Open Access

Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Review Open Access

Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Article Open Access

Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Article Open Access

Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Review Open Access

Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Review Open Access

Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Review Open Access

Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Article Open Access

Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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