Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May 2013 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer

  • Authors:
    • Hideki Tani
    • Noboru Saito
    • Makio Kobayashi
    • Shingo Kameoka
  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666, Japan, Department of Pathology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666, Japan
    Copyright: © Tani et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1381-1386
    |
    Published online on: March 27, 2013
       https://doi.org/10.3892/mmr.2013.1397
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although gastric cancer is increasingly being detected at an early stage of development, diffuse growth‑type malignant tumors, such as scirrhous gastric cancer, are usually at an advanced stage at the time of diagnosis, resulting in poor treatment outcomes. The aim of this study was to determine whether the K-sam gene and keratinocyte growth factor (KGF) expression may be used to identify malignant tumors with a poor prognosis. K-sam and KGF expression was retrospectively evaluated in samples from 86 patients with early and advanced gastric cancer according to type, by examining serum levels and using immunohistochemical staining. The associations with clinicopathological characteristics and survival were also examined. The mean serum KGF levels were 11.191±3.808 pg/ml in early stage and 10.715±3.4991 pg/ml in advanced gastric cancer patients. KGF levels were significantly higher in types 4 and 5 (14.498±3.812 pg/ml, n=6) compared with types 1, 2 and 3 (10.747±3.571 pg/ml, n=80; P=0.028). Stage classification was identified as the only significant factor which determined overall survival. Patients with KGF-positive tumors had significantly higher serum KGF levels compared with those who had KGF-negative tumors. Patients with K-sam‑positive tumors had significantly higher KGF levels compared with those who had K-sam-negative tumors. Pathological KGF expression was not significantly correlated with the degree of differentiation; however, there was a positive correlation between high K-sam expression in scirrhous gastric tumors and serum KGF levels. The present study revealed that high serum KGF levels are a risk factor for diffuse infiltrative gastric cancer and may provide a simple method of identifying patients with a poor prognosis among previously diagnosed preoperative gastric cancer patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Yamada A, Saito N, Kameoka S and Kobayashi M: Clinical significance of epidermal growth factor (EGF) expression in gastric cancer. Hepatogastroenterology. 54:1049–1052. 2007.PubMed/NCBI

2 

Hirosawa T, Saito N, Kameoka S and Kobayashi M: Clinical significance of epidermal growth factor (EGF) expression for assessing the spreading of human colon cancer. Nippon Daicho Komonbyo Gakkai Zasshi. 55:402–412. 2002. View Article : Google Scholar

3 

Soyama K, Saito N and Kameoka K: Study on adhesion molecule beta1 integrin in colorectal cancer-quantification of blood levels and immunohistological staining. Nippon Daicho Komonbyo Gakkai Zasshi. 52:119–127. 1999. View Article : Google Scholar

4 

Suda A, Saito N, Seshimo A, Kameoka S and Kobayashi M: Examination of transforming growth factor beta1 expression in the serum and tumor tissue of gastric cancer. Int Surg. 94:182–188. 2009.PubMed/NCBI

5 

Daiko W, Saito N and Kameoka S: Clinical significance of TGF-beta1 expression in evaluation of the malignancy of colorectal cancer. Nippon Daicho Komonbyo Gakkai Zasshi. 58:377–382. 2005. View Article : Google Scholar

6 

Hashimoto T, Saito N, Kameoka S, Shibata N and Kobayashi M: Clinical significance of hepatocyte growth factor and its specific receptor c-Met expression in colorectal cancer progression. Acta Histochem Cytochem. 37:139–146. 2004. View Article : Google Scholar

7 

Saito N, Nishimura H and Kameoka S: Clinical significance of fibronectin expression in colorectal cancer. Mol Med Rep. 1:77–81. 2008.PubMed/NCBI

8 

Yashiro M, Chung YS and Sowa M: Role of orthotopic fibroblasts in the development of scirrhous gastric carcinoma. Jpn J Cancer Res. 85:883–886. 1994. View Article : Google Scholar : PubMed/NCBI

9 

Finch PW and Rubin JS: Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst. 98:812–824. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Presta M, Dell’Era P, Mitola S, Moroni E, Ronca R and Rusnati M: Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. 16:159–178. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Szabo S and Sandor Z: Basic fibroblast growth factor and PDGF in GI diseases. Baillières Clin Gastroenterol. 10:97–112. 1996.PubMed/NCBI

12 

Katoh M and Katoh M: FGF signaling network in the gastrointestinal tract (Review). Int J Oncol. 29:163–168. 2006.PubMed/NCBI

13 

Nakazawa K, Yashiro M and Hirakawa K: Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. Cancer Res. 63:8848–8852. 2003.

14 

Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C and Lutterbach B: FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res. 68:2340–2348. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Yashiro M, Chung Y, Kubo T, Hato F and Sowa M: Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts. J Cancer. 74:1096–1103. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al: Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel. Jpn J Cancer Res. 77:849–853. 1986.PubMed/NCBI

17 

Nakatani H, Sakamoto H, Yoshida T, Yokota J, Tahara E, Sugimura T and Terada M: Isolation of an amplified DNA sequence in stomach cancer. Jpn J Cancer Res. 81:707–710. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Ishii H, Hattori Y, Itoh H, Kishi T, Yoshida T, Sakamoto H, Oh H, Yoshida S, Sugimura T and Terada M: Preferential expression of the third immunoglobulin-like domain of K-sam product provides keratinocyte growth factor-dependent growth in carcinoma cell lines. Cancer Res. 54:518–522. 1994.PubMed/NCBI

19 

Ishii H, Yoshida T, Oh H, Yoshida S and Terada M: A truncated K-sam product lacking the distal carboxyl-terminal portion provides a reduced level of autophosphorylation and greater resistance against induction of differentiation. Mol Cell Biol. 15:3664–3671. 1995.

20 

Itoh H, Hattori Y, Sakamoto H, Ishii H, Kishi T, Sasaki H, Yoshida T, Koono M, Sugimura T and Terada M: Preferential alternative splicing in cancer generates a K-sam messenger RNA with higher transforming activity. Cancer Res. 54:3237–3241. 1994.PubMed/NCBI

21 

Japanese Gastric Cancer Association. Japanese Classification of Gastric Carcinoma - 2nd English Edition. Gastric Cancer. 1:10–24. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Hattori Y, Itoh H, Uchino S, Hosokawa K, Ochiai A, Ino Y, Ishii H, Sakamoto H, Yamaguchi N, Yanagihara K, Hirohashi S, Sugimura T and Terada M: Immunohistochemical detection of K-sam protein in stomach cancer. Clin Cancer Res. 2:1373–1381. 1996.PubMed/NCBI

23 

Toyokawa T, Yashiro M and Hirakawa K: Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncol Rep. 21:875–880. 2009.PubMed/NCBI

24 

Nakamura K, Yashiro M, Matsuoka T, Tendo M, Shimizu T, Miwa A and Hirakawa K: A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for scirrhous gastric cancer. Gastroenterology. 131:1530–1541. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tani H, Saito N, Kobayashi M and Kameoka S: Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer. Mol Med Rep 7: 1381-1386, 2013.
APA
Tani, H., Saito, N., Kobayashi, M., & Kameoka, S. (2013). Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer. Molecular Medicine Reports, 7, 1381-1386. https://doi.org/10.3892/mmr.2013.1397
MLA
Tani, H., Saito, N., Kobayashi, M., Kameoka, S."Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer". Molecular Medicine Reports 7.5 (2013): 1381-1386.
Chicago
Tani, H., Saito, N., Kobayashi, M., Kameoka, S."Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer". Molecular Medicine Reports 7, no. 5 (2013): 1381-1386. https://doi.org/10.3892/mmr.2013.1397
Copy and paste a formatted citation
x
Spandidos Publications style
Tani H, Saito N, Kobayashi M and Kameoka S: Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer. Mol Med Rep 7: 1381-1386, 2013.
APA
Tani, H., Saito, N., Kobayashi, M., & Kameoka, S. (2013). Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer. Molecular Medicine Reports, 7, 1381-1386. https://doi.org/10.3892/mmr.2013.1397
MLA
Tani, H., Saito, N., Kobayashi, M., Kameoka, S."Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer". Molecular Medicine Reports 7.5 (2013): 1381-1386.
Chicago
Tani, H., Saito, N., Kobayashi, M., Kameoka, S."Clinical significance of keratinocyte growth factor and K-sam gene expression in gastric cancer". Molecular Medicine Reports 7, no. 5 (2013): 1381-1386. https://doi.org/10.3892/mmr.2013.1397
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team