Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury

  • Authors:
    • Man Dong
    • Tie Hong
    • Shunan Liu
    • Jing Zhao
    • Yixiao Meng
    • Jiaye Mu
  • View Affiliations

  • Published online on: April 25, 2013     https://doi.org/10.3892/mmr.2013.1443
  • Pages: 1919-1923
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Abstract

The aim of this study was to investigate the mechanism and nature of the protective effect of Inula britannica flower flavonoids (IBFF) on antioxidants and the inhibition of inflammation in liver injury. Liver injury was induced in a mouse model by intraperitoneal injection of D-Galactosamine (D-Gal; 850 mg/kg) and IBFF was administered orally at 125, 250 or 500 mg/kg once a day for 7 days. The results revealed that IBFF reversed the increases in serum aminotransferase levels and lipid peroxidation and also reversed the decreases in hepatic glutathione content. IBFF attenuated the D-Gal-induced increases in tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein levels in the liver. Our data suggest that IBFF ameliorates D-Gal-induced acute liver injury and that this protection may be due to its antioxidative and anti-inflammatory activities.
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June 2013
Volume 7 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Dong M, Hong T, Liu S, Zhao J, Meng Y and Mu J: Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury . Mol Med Rep 7: 1919-1923, 2013
APA
Dong, M., Hong, T., Liu, S., Zhao, J., Meng, Y., & Mu, J. (2013). Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury . Molecular Medicine Reports, 7, 1919-1923. https://doi.org/10.3892/mmr.2013.1443
MLA
Dong, M., Hong, T., Liu, S., Zhao, J., Meng, Y., Mu, J."Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury ". Molecular Medicine Reports 7.6 (2013): 1919-1923.
Chicago
Dong, M., Hong, T., Liu, S., Zhao, J., Meng, Y., Mu, J."Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury ". Molecular Medicine Reports 7, no. 6 (2013): 1919-1923. https://doi.org/10.3892/mmr.2013.1443