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Article

Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy

  • Authors:
    • Jun Liu
    • Kuangwen Li
    • Xiongjie Huang
    • Junfeng Xie
    • Xinfeng Huang
  • View Affiliations / Copyright

    Affiliations: Department of Hand Surgery, the Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 245-249
    |
    Published online on: May 22, 2013
       https://doi.org/10.3892/mmr.2013.1487
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Abstract

Muscle atrophy is a disease that is usually caused by denervation. The aim of the present study was to determine whether electrical stimulation by semi-implantable electrodes is capable of decreasing the levels of specific proteins associated with sciatic nerve injury-induced muscle atrophy. Male Sprague Dawley (SD) rats with damaged sciatic nerves were maintained on a 12‑h light/dark cycle. Thirty-two SD rats were randomly allocated into 4 groups (each group, n=8). The rats in group C received no electrical stimulation; the rats in groups D, N and DN received electrical stimulation by semi-implantable electrodes during the daytime alone, nighttime alone and both the daytime and nighttime, respectively. Immunoblot assays were performed to detect the expression of cellular proteins associated with muscle atrophy. The number of muscle satellite cells was determined using a microscope, indicating that electrical stimulation increased the number of muscle satellite cells. Immunoblot assay results showed that electrical stimulation reduced the expression levels of cathepsin L, calpain 1 and the ubiquitinated muscle ring finger‑1 (MuRF-1) protein. In conclusion, electrical stimulation by semi-implantable electrodes constitutes a potential method for the treatment of sciatic nerve injury-induced muscle atrophy. The decreased expression levels of the cellular proteins cathepsin L and calpain 1, as well as the ubiquitinated protein MuRF-1, are associated with the attenuation of sciatic nerve injury-induced muscle atrophy.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Li K, Huang X, Xie J and Huang X: Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy. Mol Med Rep 8: 245-249, 2013.
APA
Liu, J., Li, K., Huang, X., Xie, J., & Huang, X. (2013). Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy. Molecular Medicine Reports, 8, 245-249. https://doi.org/10.3892/mmr.2013.1487
MLA
Liu, J., Li, K., Huang, X., Xie, J., Huang, X."Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy". Molecular Medicine Reports 8.1 (2013): 245-249.
Chicago
Liu, J., Li, K., Huang, X., Xie, J., Huang, X."Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy". Molecular Medicine Reports 8, no. 1 (2013): 245-249. https://doi.org/10.3892/mmr.2013.1487
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Li K, Huang X, Xie J and Huang X: Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy. Mol Med Rep 8: 245-249, 2013.
APA
Liu, J., Li, K., Huang, X., Xie, J., & Huang, X. (2013). Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy. Molecular Medicine Reports, 8, 245-249. https://doi.org/10.3892/mmr.2013.1487
MLA
Liu, J., Li, K., Huang, X., Xie, J., Huang, X."Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy". Molecular Medicine Reports 8.1 (2013): 245-249.
Chicago
Liu, J., Li, K., Huang, X., Xie, J., Huang, X."Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy". Molecular Medicine Reports 8, no. 1 (2013): 245-249. https://doi.org/10.3892/mmr.2013.1487
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