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Article

Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups

  • Authors:
    • Ji-Eun Kim
    • Mal-Soon Shin
    • Tae-Beom Seo
    • Eun-Sang Ji
    • Seong-Soo Baek
    • Sam-Jun Lee
    • Joon-Ki Park
    • Chang-Ju Kim
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea, Department of Biochemistry, Division of Sports Science and Engineering, Korea Institute of Sports Science, Seoul 139-242, Republic of Korea, Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul 110-743, Republic of Korea, Department of Physical Education, College of Health, Social Welfare and Education, Tong Myong University, Busan 608-711, Republic of Korea, Division of Exercise and Health Science, Incheon National University, Incheon 407-772, Republic of Korea
  • Pages: 327-334
    |
    Published online on: June 12, 2013
       https://doi.org/10.3892/mmr.2013.1518
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Abstract

Autism is a neurological disorder that occurs during childhood and is characterized by impairments in social interaction and communication, as well as restricted and repetitive behaviors. Abnormalities of the cerebellum in autism include Purkinje cell loss and motor disturbance. In the present study, we evaluated the effect of treadmill exercise on motor coordination and balance in correlation with reelin expression and the rate of apoptosis in the cerebellum of autistic rat pups. For the induction of the autism-like animal models, 400 mg/kg valproic acid was subcutaneously injected into rat pups on postnatal day 14. Rat pups in the exercise groups were forced to run on a treadmill for 30 min, once a day, five times a week for 4 weeks, starting on postnatal day 28. Motor coordination and balance, as measured using the rotarod test and vertical pole test, were affected by the induction of autism. By contrast, treadmill exercise ameliorated motor dysfunction in the autistic rat pups. The expression levels of reelin, GAD67 and cyclin D1 in the cerebellum of the autistic rat pups were decreased, while the expression levels of these molecules were increased in autistic rat pups who engaged in treadmill exercise. In the cerebellum of the autistic rat pups, Bcl-2 expression was decreased and Bax expression was increased. By contrast, treadmill exercise enhanced Bcl-2 expression and suppressed Bax expression. The therapeutic effect of treadmill exercise on motor deficits may be due to the reelin-mediated anti-apoptotic effect on cerebellar Purkinje neurons.
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1 

Hardan AY, Kilpatrick M, Keshavan MS and Minshew NJ: Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autism. J Child Neurol. 18:317–324. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Vernazza-Martin S, Martin N, Vernazza A, Lepellec-Muller A, Rufo M, Massion J and Assaiante C: Goal directed locomotion and balance control in autistic children. J Autism Dev Disord. 35:91–102. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Kuehn BM: Data on autism prevalence, trajectories illuminate socioeconomic disparities. JAMA. 307:2137–2138. 2012.PubMed/NCBI

4 

Badner JA and Gershon ES: Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7. Mol Psychiatry. 7:56–66. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Fatemi SH: The role of Reelin in pathology of autism. Mol Psychiatry. 7:919–920. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Allen G and Courchesne E: Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of autism. Am J Psychiatry. 160:262–273. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Gowen E and Miall RC: Behavioural aspects of cerebellar function in adults with Asperger syndrome. Cerebellum. 4:279–289. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Schmitz C and Rezaie P: The neuropathology of autism: where do we stand? Neuropathol Appl Neurobiol. 34:4–11. 2008.PubMed/NCBI

9 

Fatemi SH, Stary JM, Halt AR and Realmuto GR: Dysregulation of Reelin and Bcl-2 proteins in autistic cerebellum. J Autism Dev Disord. 31:529–535. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Perry EK, Lee ML, Martin-Ruiz CM, Court JA, Volsen SG, Merrit J, Folly E, Iversen PE, Bauman ML, Perry RH and Wenk GL: Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain. Am J Psychiatry. 158:1058–1066. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science. 267:1456–1462. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Nuñez G, Benedict MA, Hu Y and Inohara N: Caspases: the proteases of the apoptotic pathway. Oncogene. 17:3237–3245. 1998.

13 

Kuwana T and Newmeyer DD: Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol. 15:691–699. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Baek SS, Jun TW, Kim KJ, Shin MS, Kang SY and Kim CJ: Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups. Brain Dev. 34:45–56. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Kuhn HG, Biebl M, Wilhelm D, Li M, Friedlander RM and Winkler J: Increased generation of granule cells in adult Bcl-2-overexpressing mice: a role for cell death during continued hippocampal neurogenesis. Eur J Neurosci. 22:1907–1915. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Fatemi SH: Reelin glycoprotein: structure, biology and roles in health and disease. Mol Psychiatry. 10:251–257. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Beffert U, Morfini G, Bock HH, Reyna H, Brady ST and Herz J: Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem. 277:49958–49964. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Beffert U, Weeber EJ, Durudas A, Qiu S, Masiulis I, Sweatt JD, Li WP, Adelmann G, Frotscher M, Hammer RE and Herz J: Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 47:567–579. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Delahaye NF, Coltel N, Puthier D, Barbier M, Benech P, Joly F, Iraqi FA, Grau GE, Nguyen C and Rihet P: Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice. BMC Genomics. 8:4522007. View Article : Google Scholar : PubMed/NCBI

20 

Akbarian S and Huang HS: Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res Rev. 52:293–304. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Sergaki MC, Guillemot F and Matsas R: Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1. Mol Cell Neurosci. 44:15–29. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Cotman CW, Berchtold NC and Christie LA: Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 30:464–472. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Kim SE, Ko IG, Kim BK, Shin MS, Cho S, Kim CJ, Kim SH, Baek SS, Lee EK and Jee YS: Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Exp Gerontol. 45:357–365. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Kim H, Heo HI, Kim DH, Ko IG, Lee SS, Kim SE, Kim BK, Kim TW, Ji ES, Kim JD, Shin MS, Choi YW and Kim CJ: Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats. Neurosci Lett. 504:35–39. 2011. View Article : Google Scholar

25 

Seo JH, Kim TW, Kim CJ, Sung YH and Lee SJ: Treadmill exercise during pregnancy ameliorates post-traumatic stress disorder-induced anxiety-like responses in maternal rats. Mol Med Rep. 7:389–395. 2013.PubMed/NCBI

26 

Celiberti DA, Bobo HE, Kelly KS, Harris SL and Handleman JS: The differential and temporal effects of antecedent exercise on the self-stimulatory behavior of a child with autism. Res Dev Disabil. 18:139–150. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Lang R, Koegel LK, Ashbaugh K, Regester A, Ence W and Smith W: Physical exercise and individuals with autism spectrum disorders: A systematic review. Res Autism Spectr Disord. 4:565–576. 2010. View Article : Google Scholar

28 

Petrus C, Adamson SR, Block L, Einarson SJ, Sharifnejad M and Harris SR: Effects of exercise interventions on stereotypic behaviours in children with autism spectrum disorder. Physiother Can. 60:134–145. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Wagner GC, Reuhl KR, Cheh M, McRae P and Halladay AK: A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate. J Autism Dev Disord. 36:779–793. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Uz T, Dimitrijevic N, Tueting P and Manev H: 5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior. Restor Neurol Neurosci. 20:15–20. 2002.PubMed/NCBI

31 

Bellum S, Thuett KA, Grajeda R and Abbott LC: Coordination deficits induced in young adult mice treated with methylmercury. Int J Toxicol. 26:115–121. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Sung YH, Kim SC, Hong HP, Park CY, Shin MS, Kim CJ, Seo JH, Kim DY, Kim DJ and Cho HJ: Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson’s disease mice. Life Sci. 91:1309–1316. 2012.PubMed/NCBI

33 

Shin MS, Kim BK, Lee SH, Kim TS, Heo YM, Choi JH, Kim CJ and Lim BV: Treadmill exercise enhances motor coordination and ameliorates Purkinje cell loss through inhibition on astrocyte activation in the cerebellum of methimazole-induced hypothyroidism rat pups. J Exerc Nutr Biochem. 16:73–84. 2012.(In Korean).

34 

Ritvo ER, Freeman BJ, Scheibel AB, Duong T, Robinson H, Guthrie D and Ritvo A: Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report. Am J Psychiatry. 143:862–866. 1986. View Article : Google Scholar : PubMed/NCBI

35 

Fatemi SH, Halt AR, Realmuto G, Earle J, Kist DA, Thuras P and Merz A: Purkinje cell size is reduced in cerebellum of patients with autism. Cell Mol Neurobiol. 22:171–175. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Cohen GM: Caspases: the executioners of apoptosis. Biochem J. 326:1–16. 1997.

37 

Calleja S, Salas-Puig J, Ribacoba R and Lahoz CH: Evolution of juvenile myoclonic epilepsy treated from the outset with sodium valproate. Seizure. 10:424–427. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Coppola G, Auricchio G, Federico R, Carotenuto M and Pascotto A: Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures: an open-label, randomized, parallel-group study. Epilepsia. 45:1049–1053. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Rodier PM, Ingram JL, Tisdale B, Nelson S and Romano J: Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. J Comp Neurol. 370:247–261. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Ciesielski KT and Knight JE: Cerebellar abnormality in autism: a nonspecific effect of early brain damage? Acta Neurobiol Exp (Wars). 54:151–154. 1994.PubMed/NCBI

41 

Tiemeier H, Lenroot RK, Greenstein DK, Tran L, Pierson R and Giedd JN: Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage. 49:63–70. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Kohen-Raz R, Volkmar FR and Cohen DJ: Postural control in children with autism. J Autism Dev Disord. 22:419–432. 1992. View Article : Google Scholar : PubMed/NCBI

43 

Maloku E, Covelo IR, Hanbauer I, Guidotti A, Kadriu B, Hu Q, Davis JM and Costa E: Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proc Natl Acad Sci USA. 107:4407–4411. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Quattrocchi CC, Wannenes F, Persico AM, Ciafré SA, D’Arcangelo G, Farace MG and Keller F: Reelin is a serine protease of the extracellular matrix. J Biol Chem. 277:303–309. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Yip J, Soghomonian JJ and Blatt GJ: Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications. Acta Neuropathol. 113:559–568. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Pucilowska J, Puzerey PA, Karlo JC, Galán RF and Landreth GE: Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes. J Neurosci. 32:8663–8677. 2012. View Article : Google Scholar

47 

Kim SE, Ko IG, Park CY, Shin MS, Kim CJ and Jee YS: Treadmill and wheel exercise alleviate lipopolysaccharide-induced short-term memory impairment by enhancing neuronal maturation in rats. Mol Med Rep. 7:31–36. 2013.

48 

Levinson LJ and Reid G: The effects of exercise intensity on the stereotypic behaviors of individuals with autism. Adapt Phys Activ Q. 10:255–268. 1993.

49 

Macdonald M, Esposito P and Ulrich D: The physical activity patterns of children with autism. BMC Res Notes. 4:4222011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim J, Shin M, Seo T, Ji E, Baek S, Lee S, Park J and Kim C: Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups. Mol Med Rep 8: 327-334, 2013.
APA
Kim, J., Shin, M., Seo, T., Ji, E., Baek, S., Lee, S. ... Kim, C. (2013). Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups. Molecular Medicine Reports, 8, 327-334. https://doi.org/10.3892/mmr.2013.1518
MLA
Kim, J., Shin, M., Seo, T., Ji, E., Baek, S., Lee, S., Park, J., Kim, C."Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups". Molecular Medicine Reports 8.2 (2013): 327-334.
Chicago
Kim, J., Shin, M., Seo, T., Ji, E., Baek, S., Lee, S., Park, J., Kim, C."Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups". Molecular Medicine Reports 8, no. 2 (2013): 327-334. https://doi.org/10.3892/mmr.2013.1518
Copy and paste a formatted citation
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Spandidos Publications style
Kim J, Shin M, Seo T, Ji E, Baek S, Lee S, Park J and Kim C: Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups. Mol Med Rep 8: 327-334, 2013.
APA
Kim, J., Shin, M., Seo, T., Ji, E., Baek, S., Lee, S. ... Kim, C. (2013). Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups. Molecular Medicine Reports, 8, 327-334. https://doi.org/10.3892/mmr.2013.1518
MLA
Kim, J., Shin, M., Seo, T., Ji, E., Baek, S., Lee, S., Park, J., Kim, C."Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups". Molecular Medicine Reports 8.2 (2013): 327-334.
Chicago
Kim, J., Shin, M., Seo, T., Ji, E., Baek, S., Lee, S., Park, J., Kim, C."Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups". Molecular Medicine Reports 8, no. 2 (2013): 327-334. https://doi.org/10.3892/mmr.2013.1518
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