Effect of multivitamins on plasma homocysteine in patients with the 5,10 methylenetetrahydrofolate reductase C677T homozygous state

Dell'Edera,Domenico; Tinelli,Andrea; Milazzo,Giusi   Natalia; Malvasi,Antonio; Domenico,Carone; Pacella,Elena; Pierluigi,Compagnoni; Giuseppe,Tarantino; Marcello,Guido; Francesco,Lomurno; Epifania,Annunziata   Anna

doi:10.3892/mmr.2013.1563

August 2013 Volume 8 Issue 2

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August 2013 Volume 8 Issue 2

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Article

Effect of multivitamins on plasma homocysteine in patients with the 5,10 methylenetetrahydrofolate reductase C677T homozygous state

Authors:
- Domenico Dell'Edera
- Andrea Tinelli
- Giusi Natalia Milazzo
- Antonio Malvasi
- Carone Domenico
- Elena Pacella
- Compagnoni Pierluigi
- Tarantino Giuseppe
- Guido Marcello
- Lomurno Francesco
- Annunziata Anna Epifania
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Affiliations: Unit of Cytogenetic and Molecular Genetics, Madonna delle Grazie Hospital, Matera, Italy, Department of Obstetrics and Gynecology, V. Fazzi Hospital, Lecce, Italy, S'Andrea Hosptital, Sapienza University, Rome, Italy, Department of Obstetrics and Gynecology, Santa Maria Hospital, Bari, Italy, Center of Reproduction and Andrology (CREA), Taranto, Italy, Department of Ophthalmology, Sapienza University, Rome, Italy, Unit of Ophthalmology, Madonna delle Grazie Hospital, Matera, Italy, Laboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, Faculty of Sciences, University of Salento, Lecce, Italy, Obstetrics and Gynecology Department, Umberto I Hospital, Altamura (BA), Italy, Unit of Clinical Chemistry, Madonna delle Grazie Hospital, Matera, Italy
Pages: 609-612
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Published online on: June 28, 2013

https://doi.org/10.3892/mmr.2013.1563
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Abstract

The role of hyperhomocysteinemia (HHcy) as a cardiovascular risk factor remains a matter of debate, while it correlates with folates, it demonstrates inverse correlation with plasma homocysteine (Hcy) levels and vitamin B12 levels and reduces plasma Hcy levels following supplementation with multivitamins. The purpose of this study was to demonstrate that administering multivitamins at specific doses for 90 days restores normal plasma Hcy levels in women who are homozygous for the thermolabile variant of 5,10 methylenetetrahydrofolate reductase (MTHFR C677T). We enrolled 106 healthy females aged between 30 and 42 years, who were non-smokers, non-vegetarian, normotensive and who had no history of food abuse in the previous months. Only females were enrolled in order to rule out any bias due to the variation in Hcy plasma concentrations between males and females. Patient blood sampling was performed in order to determine plasma Hcy, serum folic acid and vitamin B12 levels. Furthermore, molecular characterization of the C677T polymorphism present in the MTHFR gene, was also performed. The results of this study demonstrated that supplementation with specific multivitamins restores normal plasma Hcy levels, regardless of the MTHFR genotype. Furthermore, it is unnecessary to adminster high doses of folate to reduce plasma Hcy levels, and administering high doses of folate may cause pro-inflammatory and pro-proliferative effects.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of multivitamins on plasma homocysteine in patients with the 5,10 methylenetetrahydrofolate reductase C677T homozygous state

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Abstract

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