Effects of Nogo-A receptor antagonist on the regulation of the Wnt signaling pathway and neural cell proliferation in newborn rats with hypoxic ischemic encephalopathy

Wang,Yongxiang; Gu,Jiaxiang; Feng,Xinmin; Wang,Hua; Tao,Yuping; Wang,Jingcheng

doi:10.3892/mmr.2013.1579

September 2013 Volume 8 Issue 3

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September 2013 Volume 8 Issue 3

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Article

Effects of Nogo-A receptor antagonist on the regulation of the Wnt signaling pathway and neural cell proliferation in newborn rats with hypoxic ischemic encephalopathy

Authors:
- Yongxiang Wang
- Jiaxiang Gu
- Xinmin Feng
- Hua Wang
- Yuping Tao
- Jingcheng Wang
View Affiliations / Copyright

Affiliations: Department of Orthopedic Surgery, Clinical Medical College of Yangzhou, University of Yangzhou, Yangzhou, Jiangsu 225001, P.R. China
Pages: 883-886
|
Published online on: July 9, 2013

https://doi.org/10.3892/mmr.2013.1579
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Abstract

Hypoxic ischemic encephalopathy is a serious condition due to inadequate oxygen supply to the brain. Regeneration of neural cells is a critical process for repairing the damaged brain. Nogo has been identified as an inhibitor of neurite outgrowth that is specific to the brain. In the present study, the Nogo-A receptor (NgR) antagonist NEP1-40 was used to study the effects of inhibition of NgR on the regeneration of neural cells and the related Wnt signaling pathway in newborn rats. The investigation focused on the transcription factors regulated in the Wnt signaling pathway during the repair process, together with the proliferation of neural cells. The results indicated that c-Jun and c-Myc were the main transcription factors involved in the Wnt signaling pathway, while neural cell proliferation in the subventricular zone was increased during this process.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of Nogo-A receptor antagonist on the regulation of the Wnt signaling pathway and neural cell proliferation in newborn rats with hypoxic ischemic encephalopathy

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