Characterization of amplification patterns and target genes on the short arm of chromosome 7 in early-stage lung adenocarcinoma

  • Authors:
    • Ji Un Kang
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  • Published online on: September 17, 2013     https://doi.org/10.3892/mmr.2013.1686
  • Pages: 1373-1378
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Abstract

Chromosomal alterations are a predominant genomic force contributing to the development of lung adenocarcinoma (ADC). High density genomic arrays were conducted to identify critical genetic landmarks that may be important mediators in the formation or progression of early‑stage ADC. In this study, the most noteworthy and consistent observation was a copy number gain on the short arm of chromosome 7, which was detected in 85.7% (12/14) of cases. Notably, three distinct regions of amplification were identified between the 7p22.3 and q11.2 regions in 28.6% (4/14) of cases; at a size of 4.1 Mbp (7p22.3‑p21.1), 2.6 Mbp (7p15.2-p14.1) and 1.5 Mbp (7p12.3‑p11.2). Variations of the 7p11.2 locus that encodes EGFR are known to be oncogenic. Furthermore, potential target genes were identified that were previously not assumed to be involved in the pathogenesis of ADC, including CALM1P2 (7p11.2), HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXA10, HOXA11 and HOXA13 (7p15.2) and LOC442586, LOC442589, LOC442282, FAM20C and LOC442651 (7p22.3). The present study determined critical regions on the 7p arm of chromosome 7, which were implicated in ADC. The pattern of rearrangements on the 7p arm may be a consequence of the high density of potential targets and the identified genes at the 7p regions may aid in the development of therapeutic targets for ADC.
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November 2013
Volume 8 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kang JU: Characterization of amplification patterns and target genes on the short arm of chromosome 7 in early-stage lung adenocarcinoma. Mol Med Rep 8: 1373-1378, 2013
APA
Kang, J.U. (2013). Characterization of amplification patterns and target genes on the short arm of chromosome 7 in early-stage lung adenocarcinoma. Molecular Medicine Reports, 8, 1373-1378. https://doi.org/10.3892/mmr.2013.1686
MLA
Kang, J. U."Characterization of amplification patterns and target genes on the short arm of chromosome 7 in early-stage lung adenocarcinoma". Molecular Medicine Reports 8.5 (2013): 1373-1378.
Chicago
Kang, J. U."Characterization of amplification patterns and target genes on the short arm of chromosome 7 in early-stage lung adenocarcinoma". Molecular Medicine Reports 8, no. 5 (2013): 1373-1378. https://doi.org/10.3892/mmr.2013.1686